scholarly journals Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats

2011 ◽  
Vol 13 (2) ◽  
pp. 139-145 ◽  
Author(s):  
N Yokoi ◽  
S Hidaka ◽  
S Tanabe ◽  
M Ohya ◽  
M Ishima ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class Ii ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population

2012 ◽  
Vol 19 (4) ◽  
pp. 557-561 ◽  
Author(s):  
Rachida Raache ◽  
Khadidja Belanteur ◽  
Habiba Amroun ◽  
Amel Benyahia ◽  
Amel Heniche ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Autoimmune Diabetes ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Related Gene ◽  
Latent Autoimmune Diabetes ◽  
Histocompatibility Complex

ABSTRACTMajor histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.

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