scholarly journals Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish: Evidence for Replication From Diabetes-Related Quantitative Traits and From Independent Populations

Diabetes ◽  
2007 ◽  
Vol 56 (12) ◽  
pp. 3053-3062 ◽  
Author(s):  
E. Rampersaud ◽  
C. M. Damcott ◽  
M. Fu ◽  
H. Shen ◽  
P. McArdle ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Candidate Genes ◽  
Quantitative Traits ◽  
Genome Wide Association ◽  
Old Order Amish ◽  
Old Order ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Science ◽  
2007 ◽  
Vol 316 (5829) ◽  
pp. 1341-1345 ◽  
Author(s):  
L. J. Scott ◽  
K. L. Mohlke ◽  
L. L. Bonnycastle ◽  
C. J. Willer ◽  
Y. Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Mapping of Diabetes Susceptibility Loci in a Domestic Cat Breed with an Unusually High Incidence of Diabetes Mellitus

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1369 ◽  
Author(s):  
Lois Balmer ◽  
Caroline Ann O’Leary ◽  
Marilyn Menotti-Raymond ◽  
Victor David ◽  
Stephen O’Brien ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Candidate Genes ◽  
The United States ◽  
Domestic Cat ◽  
Nucleotide Polymorphisms ◽  
Breeding Programs ◽  
Preventative Health ◽  
Genome Wide ◽  
A Genome

Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by performing a genome-wide association scan on ABB cats. Four SNPs were associated with the ABB T2D phenotype with p values <0.005. All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D. The identification of genetic markers associated with T2D susceptibility in ABB cats will enable preventative health strategies and guide breeding programs to reduce the prevalence of T2D in these cats.

scholarly journals A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29202 ◽  
Author(s):  
Nicholette D. Palmer ◽  
Caitrin W. McDonough ◽  
Pamela J. Hicks ◽  
Bong H. Roh ◽  
Maria R. Wing ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (7) ◽  
pp. 1414-1427 ◽  
Author(s):  
Natalie R. van Zuydam ◽  
Emma Ahlqvist ◽  
Niina Sandholm ◽  
Harshal Deshmukh ◽  
N. William Rayner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Association Study ◽  
Diabetic Kidney Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Diabetic Kidney ◽  
Genome Wide ◽  
A Genome
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