scholarly journals FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1216-1226 ◽  
Author(s):  
D. Demozay ◽  
J.-C. Mas ◽  
S. Rocchi ◽  
E. Van Obberghen
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Insulin Signaling ◽  
Lipid Peroxidation Product ◽  
Peroxidation Product

scholarly journals Carotid intima-media thickness and oxidative stress markers for assessment of atherosclerosis in children with β thalassemia major

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Geetanjali Jindal ◽  
Prashant Chavan ◽  
Ravinder Kaur ◽  
Shivani Jaswal ◽  
Kamal Kumar Singhal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidized Ldl ◽  
Thalassemia Major ◽  
Lipid Peroxidation Product ◽  
Oxidative Stress Markers ◽  
Lipoprotein A ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Peroxidation Product

<p>The present study evaluates carotid intimamedia thickness (CIMT) in children with β thalassemia major to assess atherosclerosis and its relation to the underlying proposed causative mechanisms <em>via</em> lipid peroxidation product malondialdehyde (MDA), oxidized lowdensity lipoproteins (LDL), total antioxidant level, and lipid profile. A cross sectional study was conducted on 62 children (31 cases and 31 controls). CIMT by high resolution ultrasound and biochemical parameters <em>i.e.</em>, total cholesterol, triglycerides, high-density lipoproteins, LDL, Oxidized LDL, lipoprotein (a), lipid peroxidation product MDA and total antioxidant were measured in enrolled subjects and compared. In our study, CIMT was significantly increased in β thalassemia major patients’ as compared to healthy controls. Mean CIMT in cases was 0.69±0.11 mm and in controls 0.51±0.07 mm. Mean oxidized LDL (EU/mL) in cases 39.3±34.4 (range 14.4 to 160) was significantly raised (P=0.02, t test) as compared to controls 23.9±13.4 (range 12 to 70). In our study we found MDA levels (nmol/mL) to be increased in β thalassemia patients as compared to controls. Mean MDA was 10.0±3.27 (4.41 to 17.48) in cases while in controls was 6.87±4.55 (1.5 to 17.9). Our study results show CIMT as an early marker of atherogenesis in β thalassemia major. Oxidative stress markers are also increased in β thalassemia major patients and lipoprotein (a) shows a positive correlation with CIMT. The present study points towards various atherogenetic mechanisms in β thalassemia major.</p><p> </p><p>本研究评价β重型地中海贫血患儿颈动脉内膜中层厚度（CIMT），以评估动脉粥样硬化，以及与潜在通过血脂过氧化反应产物丙二醛（MDA）、氧化低密度脂蛋白（LDL）、总抗氧化水平和血脂谱所提出致病机制之间的关系。 在62名儿童（31例病例和31例对照）中进行了一项横断面研究。 在入组受试者中通过高分辨率超声和生化指标（即总胆固醇、甘油三酯、高密度脂蛋白、LDL、氧化LDL，脂蛋白（a）、血脂过氧化产物MDA和总抗氧化剂）测量CIMT并进行比较。 在我们的研究中，CIMT在β重型地中海贫血患者中比健康对照组显著增加。 病例组中的平均CIMT为0.69±0.11 mm，对照组0.51±0.07 mm。病例组中平均氧化LDL（EU/mL）为39.3±34.4（从14.4到160的范围）与对照组的23.9±13.4（12至70的范围）相比显著升高（P = 0.02，t检验）。 在我们的研究中，我们发现β地中海贫血患者中的MDA水平（nmol/mL）比对照组更高。 病例组中的平均MDA为10.0±3.27（4.41至17.48），而对照组为6.87±4.55（1.5到17.9）。 我们的研究结果表明，CIMT是β重型地中海贫血动脉粥样硬化的早期标记物。 氧化应激标记物在β重型地中海贫血患者中也有增加，脂蛋白（a）显示出与CIMT呈正相关。 本研究针对β重型地中海贫血中的各种动脉粥样硬化机制。</p>

Determination of Relationship Between Lipid Peroxidation, Antioxidant Defence, Trace Elements and Hemorheology in COPD

2018 ◽  
Author(s):  
Devrim Saribal ◽  
F Sinem Hocaoglu-Emre ◽  
Birsen Aydemir ◽  
Mehmet Can Akyolcu
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Trace Elements ◽  
Blood Viscosity ◽  
Lipid Peroxidation Product ◽  
Serum Concentrations ◽  
Copd Patients ◽  
Significant Difference ◽  
Anti Oxidant ◽  
Peroxidation Product

Background and objective: Oxidative stress has important role in pathogenesis of chronic obstructive pulmonary disease (COPD). There are studies suggesting the role of increased oxidative stress and decreased antioxidants in COPD patients. The aim of this study was to assess the levels of oxidative and anti-oxidant system elements, serum concentrations of trace elements and blood viscosity in COPD patients. Methods: Our study group consisted of 25 male patients with COPD, and 25 healthy non-smokers. The lipid peroxidation product malondialdehyde (MDA) and anti-oxidant system elements superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured spectrophotometrically. Serum concentrations of Copper (Cu), Zinc (Zn) and Iron (Fe) were determined using an atomic absorption spectrophotometer. Additionally, we measured blood viscosity using a viscosimeter. Results: Lipid peroxidation product MDA levels were found to be higher in plasma and erythrocytes. However GSH levels, SOD and Catalase enzyme activities were lower in erythrocytes of patient group than that of controls (p&lt;0,01). Fe and Zn levels were decreased, whereas Cu levels were increased in patient samples (p&lt;0,05; p&lt;0,01, respectvely). There was no statistically significant difference between plasma and blood viscosities. Conclusions: The results of this study indicate that COPD leads to the lipid peroxidation in erythrocyte membrane, and decreased levels of anti-oxidant system elements. Serum trace element concentrations were found to be altered in COPD patients, suggesting their interaction with oxidant and anti-oxidant enzymes.

scholarly journals Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 146 ◽  
Author(s):  
Fei-Xuan Wang ◽  
Hong-Yan Li ◽  
Yun-Qian Li ◽  
Ling-Dong Kong
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Lipid Peroxidation Product ◽  
Metabolism Disorder ◽  
Human Disorders ◽  
Eye Damage ◽  
Peroxidation Product ◽  
Energy Metabolism Disorder

The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.

scholarly journals The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Bettina P. Mihalas ◽  
Geoffry N. De Iuliis ◽  
Kate A. Redgrove ◽  
Eileen A. McLaughlin ◽  
Brett Nixon
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lipid Peroxidation Product ◽  
Peroxidation Product

Studying the antioxidant role of mushroom against hazards of gamma radiation exposure in male rats

2018 ◽  
Author(s):  
R. G. Hamza ◽  
A.N. El Shahat ◽  
M.N. Al-seeni
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Male Rats ◽  
Whole Body ◽  
Antioxidant Enzyme Activities ◽  
Lipid Peroxidation Product ◽  
Radiation Induced ◽  
Peroxidation Product ◽  
Histological Architecture

This study aimed to investigate the antioxidant role of dried mushroom (DM) against hazards of gamma-irradiation in male rats. In this study, exposure of rats to whole body g-radiation (6 Gy) resulted in hepatic oxidative stress (a significant increase in lipid peroxidation concomitant with a significant decrease in glutathione content and antioxidant enzyme activities); increase liver function enzymes and histopathological disorders. Treatment of irradiated rats with 10% DM significantly improved radiation-induced injury as indicated by the reduction of the indices of liver damage, lipid peroxidation product, the elevation of antioxidants and the attenuation of the tissues histological architecture. These results suggest that oyster mushroom can improve the antioxidant status and minimize the occurrence of oxidative stress- associated disorders.

Psoriasis, An inflammatory condition associated with oxidative stress

2021 ◽  
Vol 12 (4) ◽  
pp. 24-30
Author(s):  
Swati Pal ◽  
Sumit Sen ◽  
Indrajit Nath ◽  
Arun Kumar ◽  
Utpal Kumar Biswas
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Inflammatory Marker ◽  
Oxidative Stress Marker ◽  
Lipid Peroxidation Product ◽  
End Products ◽  
Peroxidation Product ◽  
Hs Crp

Background: Psoriasis is a chronic inflammatory skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. Oxidative stress can be one of the causes for the occurrence of psoriasis as well as significant contributor to its progression. Skin exposure to a number of irritants or proinflammatory agents including UVA and UVB generates ROS through the oxidative burst in infiltrating leukocytes at the site of inflammation which damages the skin cells. Measurement of the oxidative stress marker like lipid peroxidation product Malondialdehyde (MDA) and Nitric Oxide end products (NO2+NO3) along with the inflammatory marker hs-CRP in Psoriasis patients can uncover their role in disease causation, progression and development of various co-morbidities and timely prevention can significantly improve the quality of life of the psoriasis patients. Aims and Objectives: To measure the oxidative stress marker like lipid peroxidation product Malondialdehyde (MDA) and Nitric Oxide end products (NO2+NO3) along with the inflammatory marker hs-CRP in Psoriasis patients to uncover their role in disease causation, progression and development of various co-morbidities and timely prevention to significantly improve the quality of life of the psoriasis patients. Materials and Methods: Fifty patients of psoriasis mainly plaque type of either sex, in the age group of 35 ± 15.5 (range: 7-79) years were taken following inclusion and exclusion criteria. To evaluate the oxidative stress lipid peroxidation product malondialdehyde (MDA) and Nitric Oxide end products (NO2 + NO3) were measured. hs-CRP was measured as an inflammatory marker and their correlation with the disease severity and duration was evaluated. Results: A significant increase in malondialdehyde (MDA), Nitric Oxide end products (NOx) and hs-CRP levels (P<0.001) was noted in Psoriatic patients as compared to controls. There was a positive correlation between MDA, NOx and hs-CRP levels with the severity and duration of the disease. The correlation between hs-CRP and MDA and NOx also showed positive trend. Conclusion: Oxidative stress is one of the factors which can lead to the causation of Psoriasis and also significantly contribute to the disease progression and development of various co-morbidities. By measuring the oxidative stress marker and inflammatory marker in psoriasis patients early in the disease process we can employ preventive strategies for better management and improve the survival and quality of life.

scholarly journals Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation

2009 ◽  
Vol 297 (5) ◽  
pp. G907-G917 ◽  
Author(s):  
Rajat Singh ◽  
Yongjun Wang ◽  
Jörn M. Schattenberg ◽  
Youqing Xiang ◽  
Mark J. Czaja
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Fatty Liver ◽  
Signaling Pathway ◽  
Oxidant Stress ◽  
Mitogen Activated Protein Kinase ◽  
Synthetase Activity ◽  
Lipid Peroxidation Product ◽  
Jnk Signaling ◽  
Peroxidation Product

Sustained activation of the c-Jun NH2-terminal kinase (JNK) signaling pathway mediates the development and progression of experimental diet-induced nonalcoholic fatty liver disease (NAFLD). Delineating the mechanism of JNK overactivation in the setting of a fatty liver is therefore essential to understanding the pathophysiology of NAFLD. Both human and experimental NAFLD are associated with oxidative stress and resultant lipid peroxidation, which have been proposed to mediate the progression of this disease from simple steatosis to steatohepatitis. The ability of oxidants and the lipid peroxidation product 4-hydroxynonenal (HNE) to activate JNK signaling suggested that these two factors may act synergistically to trigger JNK overactivation. The effect of HNE on hepatocyte injury and JNK activation was therefore examined in cells under chronic oxidant stress from overexpression of the prooxidant enzyme cytochrome P450 2E1 (CYP2E1), which occurs in NAFLD. CYP2E1-generated oxidant stress sensitized a rat hepatocyte cell line to death from normally nontoxic concentrations of HNE. CYP2E1-overexpressing cells underwent a more profound depletion of glutathione (GSH) in response to HNE secondary to decreased γ-glutamylcysteine synthetase activity. GSH depletion led to overactivation of JNK/c-Jun signaling at the level of mitogen-activated protein kinase kinase 4 that induced cell death. Oxidant stress and the lipid peroxidation product HNE cause synergistic overactivation of the JNK/c-Jun signaling pathway in hepatocytes, demonstrating that HNE may not be just a passive biomarker of hepatic oxidant stress but rather an active mediator of hepatocellular injury through effects on JNK signaling.

scholarly journals Oxidative Stress and Antioxidant Enzymes in Pre-eclampsia

2014 ◽  
Vol 6 (1) ◽  
pp. 5-7
Author(s):  
Zakia Arshad ◽  
Nasreen Noor ◽  
Shazia Parveen ◽  
Shagufta Moin ◽  
Naheed Banu
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Free Radical ◽  
Pregnant Women ◽  
Lipid Peroxidation Product ◽  
Metabolizing Enzymes ◽  
Peroxidation Product ◽  
Group B ◽  
Circulating Levels

ABSTRACT Objective To estimate the levels of lipid peroxidation product and free radical metabolizing enzymes in normotensive pregnant women and women with pre-eclampsia. Materials and methods The study has been conducted on 50 women between the age group of 20 and 35 years. The women were divided into two groups, i.e. group A — normotensive pregnant women between 20 and 36 weeks of gestation and group B — Pregnant women with pre-eclampsia between 20 and 36 weeks of gestation. Lipid peroxidation product malondialdehyde (MDA) and antioxidant enzymes SOD, GSH and GST were estimated. Results Mean circulating levels of MDA were higher in women with pre-eclampsia as compared to normotensive pregnant women and mean circulating levels of free radical metabolizing enzymes SOD, GSH and GST were decreased in women with pre-eclampsia. Conclusion Pre-eclampsia is a state of pregnancy in which there is increased oxidative stress an depicted by increased level of free radical MDA and decreased levels of antioxidant enzyme to counter act that oxidative stress. How to cite this article Parveen S, Noor N, Moin S, Arshad Z, Banu N. Oxidative Stress and Antioxidant Enzymes in Preeclampsia. J South Asian Feder Obst Gynae 2014;6(1):5-7.

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