Studying the antioxidant role of mushroom against hazards of gamma radiation exposure in male rats

2018 ◽  
Author(s):  
R. G. Hamza ◽  
A.N. El Shahat ◽  
M.N. Al-seeni
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Male Rats ◽  
Whole Body ◽  
Antioxidant Enzyme Activities ◽  
Lipid Peroxidation Product ◽  
Radiation Induced ◽  
Peroxidation Product ◽  
Histological Architecture

This study aimed to investigate the antioxidant role of dried mushroom (DM) against hazards of gamma-irradiation in male rats. In this study, exposure of rats to whole body g-radiation (6 Gy) resulted in hepatic oxidative stress (a significant increase in lipid peroxidation concomitant with a significant decrease in glutathione content and antioxidant enzyme activities); increase liver function enzymes and histopathological disorders. Treatment of irradiated rats with 10% DM significantly improved radiation-induced injury as indicated by the reduction of the indices of liver damage, lipid peroxidation product, the elevation of antioxidants and the attenuation of the tissues histological architecture. These results suggest that oyster mushroom can improve the antioxidant status and minimize the occurrence of oxidative stress- associated disorders.

scholarly journals Carotid intima-media thickness and oxidative stress markers for assessment of atherosclerosis in children with β thalassemia major

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Geetanjali Jindal ◽  
Prashant Chavan ◽  
Ravinder Kaur ◽  
Shivani Jaswal ◽  
Kamal Kumar Singhal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidized Ldl ◽  
Thalassemia Major ◽  
Lipid Peroxidation Product ◽  
Oxidative Stress Markers ◽  
Lipoprotein A ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Peroxidation Product

<p>The present study evaluates carotid intimamedia thickness (CIMT) in children with β thalassemia major to assess atherosclerosis and its relation to the underlying proposed causative mechanisms <em>via</em> lipid peroxidation product malondialdehyde (MDA), oxidized lowdensity lipoproteins (LDL), total antioxidant level, and lipid profile. A cross sectional study was conducted on 62 children (31 cases and 31 controls). CIMT by high resolution ultrasound and biochemical parameters <em>i.e.</em>, total cholesterol, triglycerides, high-density lipoproteins, LDL, Oxidized LDL, lipoprotein (a), lipid peroxidation product MDA and total antioxidant were measured in enrolled subjects and compared. In our study, CIMT was significantly increased in β thalassemia major patients’ as compared to healthy controls. Mean CIMT in cases was 0.69±0.11 mm and in controls 0.51±0.07 mm. Mean oxidized LDL (EU/mL) in cases 39.3±34.4 (range 14.4 to 160) was significantly raised (P=0.02, t test) as compared to controls 23.9±13.4 (range 12 to 70). In our study we found MDA levels (nmol/mL) to be increased in β thalassemia patients as compared to controls. Mean MDA was 10.0±3.27 (4.41 to 17.48) in cases while in controls was 6.87±4.55 (1.5 to 17.9). Our study results show CIMT as an early marker of atherogenesis in β thalassemia major. Oxidative stress markers are also increased in β thalassemia major patients and lipoprotein (a) shows a positive correlation with CIMT. The present study points towards various atherogenetic mechanisms in β thalassemia major.</p><p> </p><p>本研究评价β重型地中海贫血患儿颈动脉内膜中层厚度（CIMT），以评估动脉粥样硬化，以及与潜在通过血脂过氧化反应产物丙二醛（MDA）、氧化低密度脂蛋白（LDL）、总抗氧化水平和血脂谱所提出致病机制之间的关系。 在62名儿童（31例病例和31例对照）中进行了一项横断面研究。 在入组受试者中通过高分辨率超声和生化指标（即总胆固醇、甘油三酯、高密度脂蛋白、LDL、氧化LDL，脂蛋白（a）、血脂过氧化产物MDA和总抗氧化剂）测量CIMT并进行比较。 在我们的研究中，CIMT在β重型地中海贫血患者中比健康对照组显著增加。 病例组中的平均CIMT为0.69±0.11 mm，对照组0.51±0.07 mm。病例组中平均氧化LDL（EU/mL）为39.3±34.4（从14.4到160的范围）与对照组的23.9±13.4（12至70的范围）相比显著升高（P = 0.02，t检验）。 在我们的研究中，我们发现β地中海贫血患者中的MDA水平（nmol/mL）比对照组更高。 病例组中的平均MDA为10.0±3.27（4.41至17.48），而对照组为6.87±4.55（1.5到17.9）。 我们的研究结果表明，CIMT是β重型地中海贫血动脉粥样硬化的早期标记物。 氧化应激标记物在β重型地中海贫血患者中也有增加，脂蛋白（a）显示出与CIMT呈正相关。 本研究针对β重型地中海贫血中的各种动脉粥样硬化机制。</p>

Metabolism of lipid peroxidation product, 4-hydroxynonenal (HNE) in rat erythrocytes: role of aldose reductase

2000 ◽  
Vol 29 (7) ◽  
pp. 642-651 ◽  
Author(s):  
Sanjay Srivastava ◽  
Bharat L Dixit ◽  
Jian Cai ◽  
Silky Sharma ◽  
Harrell E Hurst ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Aldose Reductase ◽  
Lipid Peroxidation Product ◽  
Rat Erythrocytes ◽  
Peroxidation Product

scholarly journals Cellular Apoptosis, Mitochondrial Swelling, Permeability and Cytochrome-C Level After (Fe3o4)-Nps Nanoparticles Exposure and Protective Role of Diferuloylmethane in Rats Liver

2020 ◽  
Vol 7 (1) ◽  
pp. 140-154
Author(s):  
Zina Bouteraa ◽  
Rachid Rouabhi ◽  
Fouad Menaceur ◽  
Salim Gasmi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Protective Role ◽  
Mitochondrial Swelling ◽  
Male Rats ◽  
Glutathione S Transferase ◽  
Defensive Role ◽  
Cellular Apoptosis ◽  
Cyt C

AbstractDuring recent years the defensive role of diferuloylmethane against oxidative stress and apoptosis has been experimentally documented. Fe3O4-NPs can cause cellular death by inducing oxidative stress. Present study aimed to investigate whether diferuloylmethane could protect rats mitochondria against Fe3O4-NPs intoxication. Twenty adult male rats were randomly chosen and divided into four groups: control; treated with 10 mg/kg/d of Fe3O4-NPs; treated with diferuloylmethane at the dose 20 ml/kg/d; treated with Fe3O4-NPs (10 mg/kg/d) and diferuloylmethane (20 ml/kg/d) respectively for 28 days. The results showed that Fe3O4-NPs increased the Alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipid peroxidation, mit-GSH (Glutathione), mit-CAT (Catalase), mit-GST (Glutathione S-transferase) and decreased mit-GPx (Glutathione peroxidase), with increased in mitochondrial swelling and permeability followed by the increasing level of plasmatic Cyt-c. The addition of diferuloylmethane (DFM) to these samples reduces or corrects the amount of the most of biomarkers. These findings have demonstrated that DFM can act as an antioxidant and antiapoptotic factor against damages induced by Fe3O4-NPs.

scholarly journals Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

2010 ◽  
Vol 62 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Ivana Trbojevic ◽  
Branka Ognjanovic ◽  
Natasa Djordjevic ◽  
Snezana Markovic ◽  
A.S. Stajn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Membrane Lipids ◽  
Redox Status ◽  
Protective Role ◽  
Male Rats ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
Glutathione Redox

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.

Determination of Relationship Between Lipid Peroxidation, Antioxidant Defence, Trace Elements and Hemorheology in COPD

2018 ◽  
Author(s):  
Devrim Saribal ◽  
F Sinem Hocaoglu-Emre ◽  
Birsen Aydemir ◽  
Mehmet Can Akyolcu
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Trace Elements ◽  
Blood Viscosity ◽  
Lipid Peroxidation Product ◽  
Serum Concentrations ◽  
Copd Patients ◽  
Significant Difference ◽  
Anti Oxidant ◽  
Peroxidation Product

Background and objective: Oxidative stress has important role in pathogenesis of chronic obstructive pulmonary disease (COPD). There are studies suggesting the role of increased oxidative stress and decreased antioxidants in COPD patients. The aim of this study was to assess the levels of oxidative and anti-oxidant system elements, serum concentrations of trace elements and blood viscosity in COPD patients. Methods: Our study group consisted of 25 male patients with COPD, and 25 healthy non-smokers. The lipid peroxidation product malondialdehyde (MDA) and anti-oxidant system elements superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured spectrophotometrically. Serum concentrations of Copper (Cu), Zinc (Zn) and Iron (Fe) were determined using an atomic absorption spectrophotometer. Additionally, we measured blood viscosity using a viscosimeter. Results: Lipid peroxidation product MDA levels were found to be higher in plasma and erythrocytes. However GSH levels, SOD and Catalase enzyme activities were lower in erythrocytes of patient group than that of controls (p&lt;0,01). Fe and Zn levels were decreased, whereas Cu levels were increased in patient samples (p&lt;0,05; p&lt;0,01, respectvely). There was no statistically significant difference between plasma and blood viscosities. Conclusions: The results of this study indicate that COPD leads to the lipid peroxidation in erythrocyte membrane, and decreased levels of anti-oxidant system elements. Serum trace element concentrations were found to be altered in COPD patients, suggesting their interaction with oxidant and anti-oxidant enzymes.

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