scholarly journals A Case of Bilateral Ocular Ischemic Syndrome with Bilateral Common Carotid Artery Stenosis for which Diagnosis and Treatment Selection were Difficult

2018 ◽  
Vol 46 (3) ◽  
pp. 205-209
Author(s):  
Akihiro OKADA ◽  
Yukie TERADA ◽  
Yohei TAKENOBU ◽  
Takayuki KIKUCHI ◽  
Kazumichi YOSHIDA ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Treatment Selection ◽  
Artery Stenosis ◽  
Diagnosis And Treatment ◽  
Ocular Ischemic Syndrome ◽  
Bilateral Common Carotid Artery ◽  
Ischemic Syndrome

scholarly journals Ocular Circulation and Chronic Ocular Ischemic Syndrome before and after Carotid Artery Revascularization Surgery

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Shoichiro Kawaguchi ◽  
Jun-ichi Iida ◽  
Yoshitomo Uchiyama
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Color Doppler ◽  
Artery Stenosis ◽  
Carotid Revascularization ◽  
Ocular Circulation ◽  
Ocular Ischemic Syndrome ◽  
Before And After ◽  
Revascularization Surgery ◽  
Ischemic Syndrome

Background. We evaluated the effect of carotid revascularization surgery on ocular circulation and chronic ocular ischemic syndrome (OIS).Methods. We examined ninety patients with carotid artery stenosis (more than 50% stenosis) at its origin treated with carotid endarterectomy (N=56) or carotid artery stenting (N=34). Twenty-five patients (28%) complained of chronic OIS. Ocular circulation was examined before and after revascularization surgery using ophthalmic artery (OphAr) and central retinal artery (CRA) color Doppler flow imaging.Results. (1) Ocular circulation: preoperatively, the average OphAr peak systolic flow velocity (Vs) was 0.05 m/sec, and the average CRA Vs was 0.07 m/sec. At 1 week after surgery, the average OphAr Vs significantly increased to 0.32 (P<0.05), and the average CRA Vs significantly increased to 0.11 m/sec (P<0.05). These significant improvements were sustained throughout the three months of the followup. (2) OIS: during the follow-up period (mean: 3.6 years), 15 patients (60%) showed visual acuity improvement, and no patients complained of amaurosis fugax or worsening of the chronic OIS.Conclusion. Carotid revascularization surgery was effective in improving the ocular circulation, and it was also useful for the chronic OIS due to the carotid artery stenosis.

scholarly journals Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis

2017 ◽  
Vol 37 (10) ◽  
pp. 3334-3343 ◽  
Author(s):  
Takashi Temma ◽  
Makoto Yamazaki ◽  
Jun Miyanohara ◽  
Hisashi Shirakawa ◽  
Naoya Kondo ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Oxygen Metabolism ◽  
Artery Stenosis ◽  
Spontaneous Respiration ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Metabolism ◽  
Bilateral Common Carotid Artery ◽  
Post Operation

Positron emission tomography with 15O-labeled gases (15O-PET) is important for in vivo measurement of cerebral oxygen metabolism both in clinical and basic settings. However, there are currently no reports concerning 15O-PET in mice. Here, we developed an 15O-PET method applicable to mice with spontaneous respiration of 15O-gas without a tracheotomy catheter. Sequential 15O-PET was also performed in a mouse model of chronic cerebral hypoperfusion with bilateral common carotid artery stenosis (BCAS) induced by placement of microcoils. 15O-gas with isoflurane was supplied to the nose of mouse with evacuation of excess 15O-gas surrounding the body. 15O-PET was performed on days 3, 7, 14, 21, and 28 after surgery. Cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were calculated in whole brains. A significant decrease in CBF and compensatory increase in OEF in the BCAS group produced CMRO2 values comparable to that of the sham group at three days post-operation. Although CBF and OEF in the BCAS group gradually recovered over the first 28 days, the CMRO2 showed a gradual decrease to 68% of sham values at 28 days post-operation. In conclusion, we successfully developed a noninvasive 15O-PET method for mice.

scholarly journals Cardiac Dysfunction in a Mouse Vascular Dementia Model of Bilateral Common Carotid Artery Stenosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Lulu An ◽  
Michael Chopp ◽  
Alex Zacharek ◽  
Yi Shen ◽  
Zhili Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Function ◽  
Carotid Artery ◽  
Vascular Dementia ◽  
Common Carotid Artery ◽  
Cardiac Dysfunction ◽  
Carotid Artery Stenosis ◽  
Artery Stenosis ◽  
Heart Weight ◽  
Bilateral Common Carotid Artery

Background: Cardiac function is associated with cognitive function. Previously, we found that stroke and traumatic brain injury evoke cardiac dysfunction in mice. In this study, we investigate whether bilateral common carotid artery stenosis (BCAS), a model that induces vascular dementia (VaD) in mice, induces cardiac dysfunction.Methods: Late-adult (6–8 months) C57BL/6J mice were subjected to sham surgery (n = 6) or BCAS (n = 8). BCAS was performed by applying microcoils (0.16 mm internal diameter) around both common carotid arteries. Cerebral blood flow and cognitive function tests were performed 21–28 days post-BCAS. Echocardiography was conducted in conscious mice 29 days after BCAS. Mice were sacrificed 30 days after BCAS. Heart tissues were isolated for immunohistochemical evaluation and real-time PCR assay.Results: Compared to sham mice, BCAS in mice significantly induced cerebral hypoperfusion and cognitive dysfunction, increased cardiac hypertrophy, as indicated by the increased heart weight and the ratio of heart weight/body weight, and induced cardiac dysfunction and left ventricular (LV) enlargement, indicated by a decreased LV ejection fraction (LVEF) and LV fractional shortening (LVFS), increased LV dimension (LVD), and increased LV mass. Cognitive deficits significantly correlated with cardiac deficits. BCAS mice also exhibited significantly increased cardiac fibrosis, increased oxidative stress, as indicated by 4-hydroxynonenal and NADPH oxidase-2, increased leukocyte and macrophage infiltration into the heart, and increased cardiac interleukin-6 and thrombin gene expression.Conclusions: BCAS in mice without primary cardiac disease provokes cardiac dysfunction, which, in part, may be mediated by increased inflammation and oxidative stress.

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