Systematic Review Based on Papers on Genetic Polymorphisms and Periodontal Disease

Author(s):  
Hidemichi Yuasa ◽  
Nobuyuki Hamajima ◽  
Toru Naito ◽  
Makoto Yokota
Author(s):  
E. S. Slazhneva ◽  
E. A. Tikhomirova ◽  
V. G. Atrushkevich

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.Purpose. To study a new paradigm of development of generalized periodontitis.Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.Results. The transition from a symbiotic microflora to a dysbiotic pathogenic community triggers the host's inflammatory response, which contributes to the development of periodontal diseases. Modern ideas about periodontal pathogenic bacteria dictate new requirements for the treatment of periodontal diseases. The second part of the review examines the microbial profiles of periodontal disease in various nosological forms, the mechanisms of the immune response and approaches to the treatment of periodontal disease from the perspective of biofilm infection.Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1652.1-1652
Author(s):  
A. Pandey ◽  
V. Ravindran ◽  
M. Pandey ◽  
R. Rajak ◽  
V. Pandey

Background:A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Objectives:The aim of this systematic review was to appraise the available literature exploring the relationship between AS and periodontal disease.Methods:We searched Medline & Embase databases (from their inception till October 2019) using appropriate combinations of following search items with limits ‘(English, Human)’; Ankylosing spondylitis, spondyloarthritis, spondyloarthropathies, spondyloarthritides, spinal disease, musculoskeletal disease, Rheumatic disease AND periodontitis, periodontal disease, periodontoses, parodontoses, chronic periodontitis, gum disease, gingivitis, oral health, dental health, plaque index, bleeding on probing, probing pocket depth, clinical attachment loss. This search was supplemented by the manual search of bibliographies of articles selected and conferences proceedings of EULAR. Only be reviews, observational study of cross-sectional, cohort or case control type on adult patients with AS were selected. Data was extracted from a predesigned proforma. A close association between periodontal disease and Ankylosing spondylitis (AS) has long been specualted. Both diseases are characterized by dysregulation of the host inflammatory response, leading to further destruction of soft and hard connective tissue with there being evidence of increased levels of TNF-α and various interleukins in both patients of AS and periodontitis.Results:A total number of 984 articles were identified and 12 were selcted for detailed appraisal (Figure 1, PRISMA flow chart). They were all case control studies. The prevalence of periodontitis ranged from 38% to 88% in patients with AS whereas in the control group from 26% to 71 % in controls. Out of 12 studies, two showed significant changes in Plaque Index (PI), two studies showed altered Pocket Probing Depth (PPD), three showed significant increased in Clinical Attachment Loss (CAL) and increased Bleeding On Probing (BOP) was seen in 2 studies. In 7 studies, periodontitis was seen in a significant number of patients with AS (P<0.05). All studies reported that the prevalence of periodontal disease in AS patients was higher as compared to non-AS patients.Conclusion:Our systematic review found an association between AS and periodontal disease. Patients with AS show higher prevalence of periodontitis and a poor oral hygiene as compared to healthy controls. At practice level, this systematic review underscores the need for a collaboration between dentists and rheumatologist.Disclosure of Interests:None declared


2021 ◽  
Vol 4 (3) ◽  
Author(s):  
Verónica Ramírez‐Lopera ◽  
Daniel Uribe‐Castro ◽  
Henry Bautista‐Amorocho ◽  
Jorge Alexander Silva‐Sayago ◽  
Enrique Mateus‐Sánchez ◽  
...  

2016 ◽  
Vol 87 (12) ◽  
pp. 1474-1483 ◽  
Author(s):  
Hadeel M. Abbood ◽  
Juliane Hinz ◽  
George Cherukara ◽  
Tatiana V. Macfarlane

2007 ◽  
Vol 78 (8) ◽  
pp. 1491-1504 ◽  
Author(s):  
Daiane C. Peruzzo ◽  
Bruno B. Benatti ◽  
Glaucia M.B. Ambrosano ◽  
Getúlio R. Nogueira-Filho ◽  
Enilson A. Sallum ◽  
...  

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Rubelisa Cândido Gomes de Oliveira ◽  
Camila Alves Costa ◽  
Nádia Lago Costa ◽  
Gabriela Camilo Silva ◽  
João Antônio Chaves de Souza

Author(s):  
Sonia Nath ◽  
Brianna Poirier ◽  
Xiangqun Ju ◽  
Kostas Kapellas ◽  
Dandara Haag ◽  
...  

2017 ◽  
Vol 53 (2) ◽  
pp. 156-163 ◽  
Author(s):  
E. F. de Morais ◽  
J. C. Pinheiro ◽  
R. B. Leite ◽  
P. P. A. Santos ◽  
C. A. G. Barboza ◽  
...  

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