scholarly journals The effects of genetic polymorphisms on benzene‐exposed workers: A systematic review

2021 ◽  
Vol 4 (3) ◽  
Author(s):  
Verónica Ramírez‐Lopera ◽  
Daniel Uribe‐Castro ◽  
Henry Bautista‐Amorocho ◽  
Jorge Alexander Silva‐Sayago ◽  
Enrique Mateus‐Sánchez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Genetic Polymorphisms ◽  
Exposed Workers

scholarly journals Cancer Incidence and Mortality among Petroleum Industry Workers and Residents Living in Oil Producing Communities: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (8) ◽  
pp. 4343
Author(s):  
Felix M. Onyije ◽  
Bayan Hosseini ◽  
Kayo Togawa ◽  
Joachim Schüz ◽  
Ann Olsson
Keyword(s):  
Systematic Review ◽  
Childhood Leukemia ◽  
Meta Analysis ◽  
Random Effect ◽  
Petroleum Industry ◽  
Occupational Exposures ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
Exposed Workers ◽  
Stratified Analysis

Petroleum extraction and refining are major sources of various occupational exposures and of air pollution and may therefore contribute to the global cancer burden. This systematic review and meta-analysis is aimed at evaluating the cancer risk in petroleum-exposed workers and in residents living near petroleum facilities. Relevant studies were identified and retrieved through PubMed and Web of Science databases. Summary effect size (ES) and 95% confidence intervals (CI) were analysed using random effect models, and heterogeneity across studies was assessed (I2). Overall, petroleum industry work was associated with an increased risk of mesothelioma (ES = 2.09, CI: 1.58–2.76), skin melanoma (ES = 1.34, CI: 1.06–1.70 multiple myeloma (ES =1.81, CI: 1.28–2.55), and cancers of the prostate (ES = 1.13, Cl: 1.05–1.22) and urinary bladder (ES = 1.25, CI: 1.09–1.43) and a decreased risk of cancers of the esophagus, stomach, colon, rectum, and pancreas. Offshore petroleum work was associated with an increased risk of lung cancer (ES = 1.20; 95% CI: 1.03–1.39) and leukemia (ES = 1.47; 95% CI: 1.12–1.92) in stratified analysis. Residential proximity to petroleum facilities was associated with childhood leukemia (ES = 1.90, CI: 1.34–2.70). Very few studies examined specific exposures among petroleum industry workers or residents living in oil producing communities. The present review warrants further studies on specific exposure levels and pathways among petroleum-exposed workers and residents living near petroleum facilities.

scholarly journals Association of the genetic polymorphisms in inhibiting and activating molecules of immune system with rheumatoid arthritis: A systematic review and meta-analysis

2021 ◽  
Vol 26 (1) ◽  
pp. 22
Author(s):  
Nima Rezaei ◽  
MohammadJavad Mousavi ◽  
MohammadReza Hooshangi Shayesteh ◽  
Sirous Jamalzehi ◽  
Reza Alimohammadi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Immune System ◽  
Genetic Polymorphisms ◽  
Meta Analysis

scholarly journals The impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility to COVID-19 infection and recovery: A systematic review

2021 ◽  
Vol 2 (03) ◽  
pp. 166-179
Author(s):  
Ahmed Suleiman ◽  
Tamadher Rafaa ◽  
Ali Al­rawi ◽  
Mustafa Dawood
Keyword(s):  
Systematic Review ◽  
Genetic Polymorphisms ◽  
Disease Risk ◽  
Epidemiological Studies ◽  
Genotype Distribution ◽  
Male Mortality ◽  
Risk Genes ◽  
Angiotensin Converting Enzyme 2 ◽  
Susceptibility To Infection ◽  
The Impact

Background: Epidemiological studies revealed there is a difference in susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of differences in gender with age and males being more inflicted. There is a clear indication that deaths caused by coronavirus disease 2019 (COVID-19) in males appeared at a higher rate than females across 35 nations. The implication of associated disease-risk genes, involved in the susceptibility of COVID-19 such as the angiotensin-converting enzyme 2 (ACE2), has recently received considerable attention due to their role in severe injury of lung and mediated SARS-CoV-2 entry as a host receptor. Objectives: Herein, we aimed to systematically review how two main genetic polymorphisms of ACE2 (rs2106809 and rs2074192) can affect the gender susceptibility to SARS-CoV-2 infection. Methods: To conduct this systematic review, a literature search in PubMed, Google Scholar, ScienceDirect, and Nature was made for the period 2004 to 2020. We searched for the impact of ACE2 genetic polymorphisms (rs2106809 and rs2074192) on gender susceptibility. Results: We noticed that there was a differential genotype distribution between males and females in various global populations whereas mutant variants were common in males compared to wild-type variants among females, which may reflect differences in gender susceptibility to infection with SARS-CoV-2. Females are less susceptible to coronavirus as compare to males because of the expression of ACE2 receptor. It has a double role in favour of COVID-19 and against COVID-19. Conclusions: Male mortality is greater than female mortality, which might be attributed to the ACE2 deficiency in women. Epidemiological studies have shown that the differences in sex and age have different susceptibility to SARS-CoV-2 infection.

Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review

2020 ◽  
Author(s):  
Marcela Forgerini ◽  
Rosa Camila Lucchetta ◽  
Gustavo Urbano ◽  
Tales Rubens de Nadai ◽  
Patrícia de Carvalho Mastroianni
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Genetic Polymorphisms ◽  
Upper Gastrointestinal Bleeding ◽  
Upper Gastrointestinal
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