scholarly journals Induction and Regeneration of Cementum, Periodontal Ligament and Alveolar Bone Using Recombinant Human BMP-2 with Polylactic Acid Polyglycolic Acid Copolymer and Gelatin Sponge Complex Carrier. Investigation with Dog Fenestration Model.

1999 ◽  
Vol 41 (4) ◽  
pp. 392-408 ◽  
Author(s):  
Tomoomi Odajima ◽  
Okito Hongo ◽  
Hiroshi Kato
Keyword(s):  
Polylactic Acid ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Polyglycolic Acid ◽  
Gelatin Sponge ◽  
Acid Copolymer

Tissue Engineering of a Small Hand Phalanx with a Porously Casted Polylactic Acid–Polyglycolic Acid Copolymer

2006 ◽  
Vol 12 (9) ◽  
pp. 2675-2683 ◽  
Author(s):  
Sargis Sedrakyan ◽  
Zhao Yi Zhou ◽  
Laura Perin ◽  
Kent Leach ◽  
David Mooney ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid ◽  
Polyglycolic Acid ◽  
Acid Copolymer ◽  
Small Hand

scholarly journals Clinical and Radiographic Evaluation of Nanohydroxyapatite Powder in Combination with Polylactic Acid/Polyglycolic Acid Copolymer as Bone Replacement Graft in the Surgical Treatment of Intrabony Periodontal Defects: A Retrospective Case Series Study

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 269
Author(s):  
Simone Verardi ◽  
Teresa Lombardi ◽  
Claudio Stacchi
Keyword(s):  
Surgical Treatment ◽  
Polylactic Acid ◽  
Case Series ◽  
Polyglycolic Acid ◽  
Retrospective Case ◽  
Acid Copolymer ◽  
Bone Replacement ◽  
Retrospective Case Series ◽  
Bone Replacement Graft

The aim of this retrospective case series was to evaluate the clinical efficacy of nanohydroxyapatite powder (NHA) in combination with polylactic acid/polyglycolic acid copolymer (PLGA) as a bone replacement graft in the surgical treatment of intrabony periodontal defects. Medical charts were screened following inclusion and exclusion criteria. Periodontal parameters and periapical radiographs taken before surgery and at 12-month follow-up were collected. Intra-group comparisons were performed using a two-tailed Wilcoxon signed-rank test. Twenty-five patients (13 males, 12 females, mean age 55.1 ± 10.5 years) were included in the final analysis. Mean probing depth (PD) and clinical attachment level (CAL) at baseline were 8.32 ± 1.41 mm and 9.96 ± 1.69 mm, respectively. Twelve months after surgery, mean PD was 4.04 ± 0.84 mm and CAL was 6.24 ± 1.71 mm. Both PD and CAL variations gave statistically significant results (p < 0.00001). The mean radiographic defect depth was 5.54 ± 1.55 mm and 1.48 ± 1.38 mm at baseline and at 12-month follow-up, respectively (p < 0.0001). This case series, with the limitations inherent in the study design, showed that the combination of NHA and PLGA, used as bone replacement graft in intrabony periodontal defects, may give significant improvements of periodontal parameters at 12-month follow-up.

scholarly journals Biocompatibility of electrospinning polycaprolactone, polylactic acid, their blends and copolymers scaffolds in in vitro tests if mesenchyme stem cells

2021 ◽  
Vol 8 (5) ◽  
pp. 38-49
Author(s):  
A. I. Mishanin ◽  
A. N. Panina ◽  
E. N. Bolbasov ◽  
S. I. Tverdokhlebov ◽  
A. S. Golovkin
Keyword(s):  
Stem Cells ◽  
Polylactic Acid ◽  
Biodegradable Polymers ◽  
In Vitro Study ◽  
Polyglycolic Acid ◽  
In Vitro Tests ◽  
Adhesion Properties ◽  
Acid Copolymer ◽  
Mesenchyme Stem Cells

Background. Biodegradable polymers are one of the most promising groups of materials suitable for creating tissue-engineered scaffolds. The high interest in biopolymers is associated with the possibility of creating scaffolds with desired properties, through the use of mixtures and copolymers. The determination of the key parameters of biocompatibility is the basic purpose for testing created materials.Objective. To perform the comparative in vitro study of biocompatibility properties of biopolymer scaffolds produced using polycaprolactone, polylactic acid, their mixtures and copolymers by electrospinning technology.Design and methods. The adhesion properties and cytotoxicity of scaffolds made from polycaprolactone, polylactic acid, copolymer of L- and D-isoforms of lactic acid, their mixtures and co-polymers with the addition of polyglycolic acid were investigated after scaffolds co-cultivation with human mesenchyme stem cells (MSC).Results. The largest number of spread spindle-shaped MSCs was on the surface of polymers containing polyglycolic acid. Besides, the cells on the surface of the copolymer with polyglycolic acid had the morphology closest to the control. The lowest number of living cells was found on the surface of polylactic acid scaffolds, and the highest on the surface of samples from of polycaprolactone and polylactic acid blend.Conclusion. Thus, all tested polymers had good adhesion properties in experiments with human mesenchyme stem cells were possessed by biodegradable polymers with the addition of polyglycolic acid. 

scholarly journals Osteoclastic effects of mBMMSCs under compressive pressure during orthodontic tooth movement

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jing Wang ◽  
Delong Jiao ◽  
Xiaofeng Huang ◽  
Yuxing Bai
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Normal Saline ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Mouse Bone Marrow ◽  
Micro Ct ◽  
Tail Vein

Abstract Background During orthodontic tooth movement (OTM), alveolar bone remodelling is closely related to mechanical force. It is unclear whether stem cells can affect osteoclastogenesis to promote OTM. This study aimed to investigate the role of mouse bone marrow mesenchymal stem cells (mBMMSCs) under compression load in OTM. Methods A mouse OTM model was established, and GFP-labelled mBMMSCs and normal saline were injected into different groups of mice by tail vein injection. OTM distance was measured using tissue specimens and micro-computed tomography (micro-CT). The locations of mBMMSCs were traced using GFP immunohistochemistry. Haematoxylin-eosin staining, tartrate-resistant acid phosphate (TRAP) staining and immunohistochemistry of Runx2 and lipoprotein lipase were used to assess changes in the periodontal ligament during OTM. mBMMSCs under compression were co-cultured with mouse bone marrow-derived macrophages (mBMMs), and the gene expression levels of Rankl, Mmp-9, TRAP, Ctsk, Alp, Runx2, Ocn and Osterix were determined by RT-PCR. Results Ten days after mBMMSCs were injected into the tail vein of mice, the OTM distance increased from 176 (normal saline) to 298.4 μm, as determined by tissue specimen observation, and 174.2 to 302.6 μm, as determined by micro-CT metrological analysis. GFP-labelled mBMMSCs were mostly located on the compressed side of the periodontal ligament. Compared to the saline group, the number of osteoclasts in the alveolar bone increased significantly (P < 0.01) on the compressed side in the mBMMSC group. Three days after mBMMSC injection, the number of Runx2-GFP double-positive cells on the tension side was significantly higher than that on the compression side. After applying compressive force on the mBMMSCs in vitro for 2 days, RANKL expression was significantly higher than in the non-compression cells, but expression of Alp, Runx2, Ocn and Osterix was significantly decreased (P < 0.05). The numbers of osteoclasts differentiated in response to mBMMs co-cultured with mBMMSCs under pressure load and expression of osteoclast differentiation marker genes (Mmp-9, TRAP and Ctsk) were significantly higher than those in mBMMs stimulated by M-CSF alone (P < 0.05). Conclusions mBMMSCs are not only recruited to the compressed side of the periodontal ligament but can also promote osteoclastogenesis by expressing Rankl, improving the efficiency of OTM.

Bullet for periodontal disease in future: Chemically modified tetracyclines

2021 ◽  
pp. 1-7
Author(s):  
Shivani Sachdeva ◽  
Ameet Mani ◽  
Harish Saluja
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Ligament ◽  
Host Response ◽  
Alveolar Bone ◽  
Gastrointestinal Toxicity ◽  
Collagenolytic Activity ◽  
Periodontal Pathogens ◽  
Oral Biofilm ◽  
Chemically Modified ◽  
Chemically Modified Tetracyclines

Chronic periodontitis is nowadays popularly regarded as Dysbiosis, [1] which causes destruction of tissues rich in collagen like periodontal ligament, alveolar bone and gingival connective tissue. The oral biofilm comprises many periodontal pathogens better regarded as ‘triggers’ in causing chronic periodontitis. Since, not everyone will be affected in the same manner due to periodontal pathogens. Some might not elicit a host response while, the others might have exaggerated response. So, host modulation therapy came into existence to counteract the exaggerated host response. The chemically modified tetracyclines (CMTs) have emerged to inhibit the inflammatory response or to reduce the collagenolytic activity of host. Though a derivative of tetracyclines, it still lacks an antimicrobial action and hence, can be used for periodontitis for longer duration with no adverse effects of gastrointestinal toxicity which parent tetracyclines have.

scholarly journals Intrusive Dental Injuries in Children: Manifestations and Management

2014 ◽  
Vol 48 (2) ◽  
pp. 53-62
Author(s):  
Sarabjot Kaur Bhatia
Keyword(s):  
Young Adults ◽  
Periodontal Ligament ◽  
Systematic Approach ◽  
Alveolar Bone ◽  
Dental Trauma ◽  
Children And Young Adults ◽  
Traumatic Dental Injuries ◽  
Mandibular Teeth ◽  
Dental Injuries ◽  
Supporting Structures

ABSTRACT Traumatic dental injuries occur frequently in children and young adults. Orofacial trauma that results in fractured, displaced or lost teeth can have signifi cant negative functional, esthetic and psychological effect on child. Intrusive luxation of teeth results in axial impacts on maxillary and mandibular teeth and is considered one of the most severe types of dental trauma because of the risk for damage to the periodontal ligament, pulp and alveolar bone. To correctly diagnose the injury, effi ciently determine the extent of injury to teeth and periodontium and supporting structures and to have a favorable outcome after management requires a systematic approach. How to cite this article Gauba K, Goyal A, Bhatia SK. Intrusive Dental Injuries in Children: Manifestations and Management. J Postgrad Med Edu Res 2014;48(2):53-62.

scholarly journals Role of Zinc Transporter ZIP13 in Degenerative Changes in Periodontal Ligament and Alveolar Bone

2016 ◽  
Vol 25 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Yayoi Idaira ◽  
Takaaki Munemasa ◽  
Toshiyuki Fukada ◽  
Shinji Shimoda ◽  
Yoshinobu Asada
Keyword(s):  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Zinc Transporter ◽  
Degenerative Changes
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