Tissue Engineering of a Small Hand Phalanx with a Porously Casted Polylactic Acid–Polyglycolic Acid Copolymer

2006 ◽  
Vol 12 (9) ◽  
pp. 2675-2683 ◽  
Author(s):  
Sargis Sedrakyan ◽  
Zhao Yi Zhou ◽  
Laura Perin ◽  
Kent Leach ◽  
David Mooney ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid ◽  
Polyglycolic Acid ◽  
Acid Copolymer ◽  
Small Hand

scholarly journals Clinical and Radiographic Evaluation of Nanohydroxyapatite Powder in Combination with Polylactic Acid/Polyglycolic Acid Copolymer as Bone Replacement Graft in the Surgical Treatment of Intrabony Periodontal Defects: A Retrospective Case Series Study

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 269
Author(s):  
Simone Verardi ◽  
Teresa Lombardi ◽  
Claudio Stacchi
Keyword(s):  
Surgical Treatment ◽  
Polylactic Acid ◽  
Case Series ◽  
Polyglycolic Acid ◽  
Retrospective Case ◽  
Acid Copolymer ◽  
Bone Replacement ◽  
Retrospective Case Series ◽  
Bone Replacement Graft

The aim of this retrospective case series was to evaluate the clinical efficacy of nanohydroxyapatite powder (NHA) in combination with polylactic acid/polyglycolic acid copolymer (PLGA) as a bone replacement graft in the surgical treatment of intrabony periodontal defects. Medical charts were screened following inclusion and exclusion criteria. Periodontal parameters and periapical radiographs taken before surgery and at 12-month follow-up were collected. Intra-group comparisons were performed using a two-tailed Wilcoxon signed-rank test. Twenty-five patients (13 males, 12 females, mean age 55.1 ± 10.5 years) were included in the final analysis. Mean probing depth (PD) and clinical attachment level (CAL) at baseline were 8.32 ± 1.41 mm and 9.96 ± 1.69 mm, respectively. Twelve months after surgery, mean PD was 4.04 ± 0.84 mm and CAL was 6.24 ± 1.71 mm. Both PD and CAL variations gave statistically significant results (p < 0.00001). The mean radiographic defect depth was 5.54 ± 1.55 mm and 1.48 ± 1.38 mm at baseline and at 12-month follow-up, respectively (p < 0.0001). This case series, with the limitations inherent in the study design, showed that the combination of NHA and PLGA, used as bone replacement graft in intrabony periodontal defects, may give significant improvements of periodontal parameters at 12-month follow-up.

scholarly journals Biocompatibility of electrospinning polycaprolactone, polylactic acid, their blends and copolymers scaffolds in in vitro tests if mesenchyme stem cells

2021 ◽  
Vol 8 (5) ◽  
pp. 38-49
Author(s):  
A. I. Mishanin ◽  
A. N. Panina ◽  
E. N. Bolbasov ◽  
S. I. Tverdokhlebov ◽  
A. S. Golovkin
Keyword(s):  
Stem Cells ◽  
Polylactic Acid ◽  
Biodegradable Polymers ◽  
In Vitro Study ◽  
Polyglycolic Acid ◽  
In Vitro Tests ◽  
Adhesion Properties ◽  
Acid Copolymer ◽  
Mesenchyme Stem Cells

Background. Biodegradable polymers are one of the most promising groups of materials suitable for creating tissue-engineered scaffolds. The high interest in biopolymers is associated with the possibility of creating scaffolds with desired properties, through the use of mixtures and copolymers. The determination of the key parameters of biocompatibility is the basic purpose for testing created materials.Objective. To perform the comparative in vitro study of biocompatibility properties of biopolymer scaffolds produced using polycaprolactone, polylactic acid, their mixtures and copolymers by electrospinning technology.Design and methods. The adhesion properties and cytotoxicity of scaffolds made from polycaprolactone, polylactic acid, copolymer of L- and D-isoforms of lactic acid, their mixtures and co-polymers with the addition of polyglycolic acid were investigated after scaffolds co-cultivation with human mesenchyme stem cells (MSC).Results. The largest number of spread spindle-shaped MSCs was on the surface of polymers containing polyglycolic acid. Besides, the cells on the surface of the copolymer with polyglycolic acid had the morphology closest to the control. The lowest number of living cells was found on the surface of polylactic acid scaffolds, and the highest on the surface of samples from of polycaprolactone and polylactic acid blend.Conclusion. Thus, all tested polymers had good adhesion properties in experiments with human mesenchyme stem cells were possessed by biodegradable polymers with the addition of polyglycolic acid. 

Clindamycin-loaded nanofibers of polylactic acid, elastin and gelatin for use in tissue engineering

2021 ◽  
Author(s):  
M. M. Castillo-Ortega ◽  
I. Y. López-Peña ◽  
D. E. Rodríguez-Félix ◽  
T. Del Castillo-Castro ◽  
J. C. Encinas-Encinas ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid

Tissue engineering needs new biomaterials: Poly(xylitol-dodecanedioic acid)–co-polylactic acid (PXDDA-co-PLA) and its nanocomposites

2021 ◽  
Vol 152 ◽  
pp. 110469
Author(s):  
Amir Sotoudeh ◽  
Goldis Darbemamieh ◽  
Vahabodin Goodarzi ◽  
Shahrokh Shojaei ◽  
Azadeh Asefnejad
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid ◽  
Dodecanedioic Acid

ANALYSIS OF THE INTERACTION BETWEEN STEM CELLS AND POLYLACTIC ACID (PLA) SCAFFOLDS FOR APPLICATIONS IN TISSUE ENGINEERING

Cytotherapy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 3-4
Author(s):  
G Biagini ◽  
BH Marcon ◽  
T Pereira ◽  
LF Berti ◽  
AC Senegaglia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Polylactic Acid

scholarly journals Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 571-599
Author(s):  
Ricardo Donate ◽  
Mario Monzón ◽  
María Elena Alemán-Domínguez
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
State Of The Art ◽  
Biological Properties ◽  
Design Stage ◽  
Bone Scaffolds ◽  
Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

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