scholarly journals An immunopathological study of periodontal disease. Chronic sensitization by oral bacteria and periodontitis.

1988 ◽  
Vol 30 (2) ◽  
pp. 506-514
Author(s):  
Ken NISHIDA ◽  
Kenichi UOBE ◽  
Tetsunari NISHIKAWA ◽  
Masahiro WATO ◽  
Seiji WADA ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Oral Bacteria

Relationship between halitosis and periodontal disease - associated oral bacteria in tongue coatings

2013 ◽  
Vol 12 (2) ◽  
pp. 145-151 ◽  
Author(s):  
T Amou ◽  
D Hinode ◽  
M Yoshioka ◽  
D Grenier
Keyword(s):  
Periodontal Disease ◽  
Oral Bacteria

A Radiographic Assessment of Dental Morbidity in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplant: A Retrospective Study

2020 ◽  
pp. 232020682097598
Author(s):  
Taggreed Wazzan ◽  
Rohan Jagtap ◽  
Mahmoud Mona ◽  
Joseph Katz
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Retrospective Study ◽  
Periodontal Disease ◽  
Stem Cell Transplant ◽  
Descriptive Analysis ◽  
Autologous Stem Cell Transplant ◽  
Oral Bacteria ◽  
High Risk Population ◽  
Cell Transplant

Aim: To assess the dental and oral morbidity in multiple myeloma patients as expressed in dental radiographs before autologous stem cell transplant. Materials and Methods: A retrospective study involving 79 multiple myeloma patients was designed to collect data prior to their autologous stem cell transplant. Patients were seen at the oral medicine clinic at the University of Florida College of Dentistry during the years 2010–2013. Through available patient data and interpretation of radiographs, the following variables were recorded: age, gender, carious lesions, periodontal disease, and periapical radiolucency. In addition, the incidence of root fragment retention and the presence of punched-out osteolytic lesions were recorded. Cochran–Mantel–Haenszel (CMH) tests and logistic regression were performed for descriptive analysis and presentation of the data. Results: Seventy-nine multiple myeloma patients were recruited for this study. Ages ranged from 28 to 79 years (mean = 61, SD = 9.6), including 41 (51.9%) females and 38 (48.1%) males. The results demonstrated dental decay in 64.56% of patients, periodontal disease in 62.03%, apical rarefying osteitis in 13.92% of patients, and punched-out lesions in 24.05% of patients. Conclusion: Our study indicates high dental morbidity in multiple myeloma patients prior to autologous stem cell transplant. The elimination of foci of infection is highly recommended prior to autologous stem cell transplant for this high-risk population because of the potential risk of bacteremia/septicemia from oral bacteria associated with dental morbidity.

scholarly journals Porphyromonas spp., Fusobacterium spp., and Bacteroides spp. dominate microbiota in the course of macropod progressive periodontal disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabine Yip ◽  
Manijeh Mohammadi Dehcheshmeh ◽  
David J. McLelland ◽  
Wayne S. J. Boardman ◽  
Sugiyono Saputra ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Ribosomal Rna ◽  
South Australia ◽  
Illumina Miseq ◽  
Oral Bacteria ◽  
Microbial Interactions ◽  
P Value ◽  
Bonferroni Correction ◽  
Linear Discriminant ◽  
Clinical Records

AbstractMacropod progressive periodontal disease (MPPD) is a necrotizing, polymicrobial, inflammatory disease commonly diagnosed in captive macropods. MPPD is characterized by gingivitis associated with dental plaque formation, which progresses to periodontitis and then to osteomyelitis of the mandible or maxilla. However, the underlying microbial causes of this disease remain poorly understood. In this study, we collected 27 oral plaque samples and associated clinical records from 22 captive Macropodidae and Potoroidae individuals that were undergoing clinical examination at Adelaide and Monarto Zoos in South Australia (15 healthy, 7 gingivitis and 5 periodontitis-osteomyelitis samples). The V3-V4 region of the 16S ribosomal RNA gene was sequenced using an Illumina Miseq to explore links between MPPD and oral bacteria in these animals. Compositional differences were detected between the microbiota of periodontitis-osteomyelitis cases compared to healthy samples (p-value with Bonferroni correction < 0.01), as well as gingivitis cases compared to healthy samples (p-value with Bonferroni correction < 0.05) using Permutational Multivariate Analysis of Variance (PERMANOVA). An overabundance of Porphyromonas, Fusobacterium, and Bacteroides taxa was also identified in animals with MPPD compared to healthy individuals using linear discriminant analysis effect size (LEfSe; p =  < 0.05). An increased abundance of Desulfomicrobium also was detected in MPPD samples (LEfSe; p < 0.05), which could potentially reflect differences in disease progression. This is the first microbiota analysis of MPPD in captive macropods, and these results support a polymicrobial pathogenesis of MPPD, suggesting that the microbial interactions underpinning MPPD may be more complex than previously documented.

Monoclonal antibodies to lipopolysaccharide of four oral bacteria associated with periodontal disease

1993 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Charles E. Shelburne ◽  
Gregory P. Sandberg ◽  
Christine A. Binsfeld ◽  
Larry F. Wolff ◽  
Russell A. Curry
Keyword(s):  
Monoclonal Antibodies ◽  
Periodontal Disease ◽  
Oral Bacteria

scholarly journals Antimicrobial and Substantivity Properties of Silver Nanoparticles against Oral Microbiomes Clinically Isolated from Young and Young-Adult Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
León Francisco Espinosa-Cristóbal ◽  
Carolina Holguín-Meráz ◽  
Erasto Armando Zaragoza-Contreras ◽  
Rita Elizabeth Martínez-Martínez ◽  
Alejandro Donohue-Cornejo ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Young Adult ◽  
Dental Caries ◽  
Periodontal Disease ◽  
Dental Plaque ◽  
Bacterial Species ◽  
Inhibitory Effect ◽  
Oral Bacteria ◽  
Oral Microbiome ◽  
Oral Biofilms

The dental plaque is an oral microbiome hardly associated to be the etiological agent of dental caries and periodontal disease which are still considered serious health public problems. Silver nanoparticles (AgNPs) have demonstrated to have good antimicrobial properties affecting a wide variety of microorganisms, including oral bacteria; however, there is no scientific information that has evaluated the antimicrobial effect of AgNPs against clinical oral biofilms associated with dental caries and periodontal disease. The aim of this study was to determine the antimicrobial and substantivity effects of AgNPs in oral biofilms isolated clinically from patients with dental caries and periodontal disease. Sixty-seven young and young-adult subjects with dental caries and periodontal disease were clinically sampled through the collection of subgingival dental plaque. The inhibitory effect of AgNPs was performed with standard microbiological assays by triplicate using two sizes of particle. Polymerase chain reaction (PCR) assay was used to identify the presence of specific bacterial species. All AgNPs showed an inhibitory effect for all oral biofilms for any age and, generally, any gender (p>0.05); however, the effectiveness of the antimicrobial and substantivity effects was related to particle size, time, and gender (p<0.05). The identified microorganisms were S. mutans, S. sobrinus, S. sanguinis, S. gordonii, S. oralis, P. gingivalis, T. forsythia, and P. intermedia. The AgNPs could be considered as a potential antimicrobial agent for the control and prevention of dental caries and periodontal disease.

scholarly journals Periodontal Disease, Inflammation and Atherosclerosis Progression in Patients with Acute Coronary Syndromes – the ATHERODENT Study

2018 ◽  
Vol 4 (1) ◽  
pp. 17-23
Author(s):  
Theodora Benedek ◽  
Ioana Rodean ◽  
Mihaela Ratiu ◽  
Nora Rat ◽  
Lia Yero Eremie ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Systemic Inflammation ◽  
Acute Coronary Syndromes ◽  
Left Ventricular ◽  
Oral Bacteria ◽  
Imaging Biomarkers ◽  
Atherosclerosis Progression ◽  
Atheromatous Plaques ◽  
Rate Of Progression ◽  
Coronary Syndromes

Abstract Recent studies have shown that systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and the development of acute coronary syndromes (ACS). The aim of the ATHERODENT study (Protocol Record Number CM0117-ATD) is to assess the interrelation between PD, inflammation, and the progression of coronary atherosclerosis in patients with ACS. Material and methods: This case-control observational study will enroll 100 patients (group 1 – ACS and associated PD, and group 2 – ACS and no PD), in whom the following data will be collected: (1) demographic and clinical data; (2) cardiovascular risk factors; (3) full characterization of PD markers; (4) systemic inflammatory biomarkers; (5) imaging biomarkers derived from transthoracic echocardiography, computed tomography, coronary angiography, optical coherence tomography, and intravascular ultrasound; and (6) assessment of the presence of specific oral bacteria in samples of coronary plaques collected by coronary atherectomy, which will be performed during percutaneous revascularization interventions, when indicated in selected cases, in the atherectomy sub-study. The follow-up will be performed at 1, 3, 6, 12, 15, 18, and 24 months. The primary endpoint of the study will be represented by the rate of major adverse cardiovascular events (MACE) in PD vs. non-PD patients and in correlation with: (1) the level of systemic inflammation triggered by PD and/or by ACS at baseline; (2) the vulnerability degree of atheromatous plaques in the coronary tree (culprit and non-culprit lesions); and (3) the presence and burden of oral bacteria in atheromatous plaques. Secondary endpoints will be represented by: (1) the rate of progression of vulnerability degree of non-culprit coronary plaques; (2) the rate of progression of atheromatous burden and calcium scoring of the coronary tree; and (3) the rate of occurrence of left ventricular remodeling and post-infarction heart failure. The ATHERODENT study has been registered in clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT03395041).

scholarly journals The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242091
Author(s):  
Mao Nishikawa ◽  
Michitaka Honda ◽  
Ryosuke Kimura ◽  
Ayaka Kobayashi ◽  
Yuji Yamaguchi ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Oral Bacteria ◽  
Periodontal Pocket ◽  
Resected Stomach ◽  
Bacterial Strains ◽  
Drainage Fluid ◽  
Stomach Mucosa ◽  
Abdominal Infection ◽  
Severe Periodontal Disease ◽  
Intra Abdominal Infection

Background Perioperative oral management has been reported to be effective for preventing postoperative infectious complications. In addition, severe periodontal disease was identified as the significant risk factor for complications after gastrointestinal surgery. We investigated the bacteriological association between the periodontal pocket, stomach mucosa and drainage fluid to determine whether oral bacteria directly cause intra-abdominal infection after gastrectomy. Methods Patients who were scheduled to undergo surgery for gastric cancer were prospectively enrolled. We evaluated the similarity of bacterial strains in periodontal pocket, stomach mucosa and fluid from drainage tube. Gingival crevicular fluid and dental plaque were collected from the periodontal pocket and cultured to detect bacteria. Specimens from the resected stomach were collected and used for bacterial culturing. Drainage fluid from the abdominal cavity was also cultured. Results All of 52 patients were enrolled. In the periodontal pocket, α-Streptococcus spp., Neisseria sp., and Prevotella sp. were mainly detected. Bacterial cultures in the stomach mucosa were positive in 26 cases. In 20 cases (76.9%), the detected strains were the same as those in the periodontal pocket. Six patients had the postoperative intra-abdominal infection after gastrectomy, and the same bacterial strains was detected in both of drainage fluid and periodontal pocket in two patients with severe periodontal disease. Conclusions We found the bacteriological association that same strain detected in periodontal pocket, stomach and in intra-abdominal drainage fluid after gastrectomy in patients with periodontal disease.

scholarly journals Aggregatibacter actinomycetemcomitans and Atherosclerosis

2020 ◽  
pp. 1-6
Author(s):  
Yutang Wang ◽  
Dinh Tam Nguyen ◽  
Jack Anesi ◽  
Michelle Steicke ◽  
Yutang Wang
Keyword(s):  
Periodontal Disease ◽  
Atherosclerotic Lesion ◽  
Cell Types ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Lesion Size ◽  
Oral Bacteria ◽  
Periodontal Pocket ◽  
Inflammatory Condition ◽  
Worldwide Population ◽  
Bacterial Plaque

Periodontal disease is an inflammatory condition around the teeth which affects 20-50% of the worldwide population. In periodontal disease, the bacterial plaque destroys the epithelium of the periodontal pocket and breaks the barrier that separates the tissue and the circulation, allowing oral bacteria and their endotoxins and exotoxins to enter the bloodstream. This can cause health problems, such as atherosclerosis. Aggregatibacter actinomycetemcomitans (Aa) is commonly found in patients with periodontitis and the number of Aa is associated with atherosclerotic lesion size in humans. This review focuses on Aa and atherosclerosis with an emphasis on the interaction of Aa with cell types involved in atherosclerosis formation.

scholarly journals Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

2018 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Gabriel R. Fernandes ◽  
Débora Cerqueira Calderaro ◽  
Santuza Maria Souza Mendonça ◽  
Janine Mayra Silva ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Bacterial Load ◽  
Oral Bacteria ◽  
The Body ◽  
Rrna Gene ◽  
Oral Microbiota ◽  
Periodontal Inflammation ◽  
The Impact ◽  
Subgingival Microbiota

AbstractRheumatoid arthritis (RA) is an autoimmune disorder associated with increased periodontal destruction. It is thought that RA increases the risk of periodontal disease; it is not known how it influences the oral microbiota. Our aim was to analyze the impact of RA on subgingival microbiota and its association with periodontal inflammation and RA activity. Forty-two patients with RA were compared to 47 control subjects without RA. Patients were screened for probing depth, clinical attachment level, bleeding on probing and classified as with or without periodontitis. Subgingival plaque was examined by Illumina MiSeq Sequencing of 16S rRNA gene V4 region and inflammatory cytokines were measured in saliva. RA was associated to severe periodontal disease. In addition, the severity of RA, reflected by the number of tender and swollen joints, was significantly correlated with the presence of pathogenic oral bacteria (i.e. Fusobacterium nucleatum and Treponema socransky). Non-periodontitis RA patients compared to healthy controls had increased microbial diversity and bacterial load, higher levels of pathogenic species (Prevotella, Selenomonas, Anaeroglobus geminatus, Parvimonas micra, Aggregatibacter actinomycetemcomitans) and reduction of health-related species (Streptococcus, Rothia aeria, Kingela oralis). Genes involved with bacterial virulence (i.e. lipopolysaccharide biosynthesis, peptidases) were more prevalent in the subgingival metagenome of subjects with RA. In addition, the degree of oral inflammation reflected by IL-2, IL-6, TNF-α, IFN-γ salivary levels was increased in non-periodontitis RA patients in comparison with controls. Our findings support the hypothesis that RA triggers dysbiosis of subgingival microbiota, which may contribute to worsening periodontal status.Author SummaryRheumatoid arthritis (RA) is an autoimmune disease characterized by joints inflammation, swelling, pain and stiffness. Exactly what starts this disease is still unclear. Some recent studies have suggested mucosal surfaces in the body, like those in the gums, could affect the disease process. It has been observed that people with RA have higher risk of periodontitis (a bacterial inflammatory disease of the gums), compared with the general population, and this may be the start of the autoimmune process. Also, periodontitis increases the severity of RA while interventions by treating periodontitis can improve the symptoms of RA. One of the possible mechanisms that link the higher prevalence of periodontitis in RA patients is the dysbiosis of the oral microbiota triggered by the chronic inflammation in RA. Increased levels of molecules of inflammation may affect the oral environment and change the type of bacteria that live there. Here, we examined RA patients and healthy subjects, screening their oral health and inflammatory markers. We collected their saliva and the dental plaque from the space between the teeth and the gum. We found that RA patients exhibited severe periodontitis, increased levels of inflammatory mediators on their saliva and distinct bacterial communities, with higher proportions of bacteria species linked to periodontal disease, even in patients without periodontitis. We also found that the presence of these bacteria species was linked to worse RA conditions. Our study provides new insights to understand the bi-directional mechanisms linking periodontal disease to the development of RA, showing that we need to pay attention to the oral cavity in patients with RA and refer people for dental evaluation. This practice might have a positive impact in the course of RA.

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