scholarly journals Histopathological study on the healing of experimentally produced bone defects following blend bone grafts of fresh autogenous bone and decalcified bone matrix powder in dogs.

1987 ◽  
Vol 29 (3) ◽  
pp. 706-748
Author(s):  
Kazuya YAMANOUCHI
Keyword(s):  
Bone Matrix ◽  
Bone Grafts ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Histopathological Study ◽  
Matrix Powder ◽  
Decalcified Bone Matrix

ALLOGRAFT BONE APPLICATION IN THE RAT CALVARIAL BONE DEFECT MODEL: A HISTOPATHOLOGICAL STUDY

2021 ◽  
pp. 22-24
Author(s):  
Büşra Deveci ◽  
Ahmet Dağ ◽  
Firat Asir ◽  
Ebru Gökalp Özkorkmaz ◽  
Engin Deveci
Keyword(s):  
Bone Defect ◽  
Bone Matrix ◽  
Scar Tissue ◽  
Bone Defects ◽  
Defect Group ◽  
Male Rats ◽  
Histopathological Study ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

Trauma, neoplasms, infections, and congenital anomalies may be the reason for the calvarial bone defects. For eliminating bone defects in the cranial region to stimulate bone regeneration different graft types have been tried. In our study, we aimed to investigate the effects of allograft application in the rat calvarial bone defect model. For this purpose, 14 Wistar male rats were determined; defect (n=7) and defect + graft (n=7) groups. . The frontal bone was opened and a circular full thickness bone defect (5 mm) was created in the midline. Allograft material was placed in the defect area. All animals were sacriced after 28 days and the calvarial bones were followed up for routine histologic preparations. Sections were stained with H-E and scoring for histopathological parameters (inammation, brosis, osteoclast number, osteoblast number, osteocyte number, matrix formation, new bone trabecular diameter). In our study, inammation, brosis and osteoclast numbers decreased in the defect + graft group compared to the defect group, and osteocyte, osteoblast, matrix formation and bone trabecular diameter has increased signicantly. Histopathological evaluation revealed scar tissue, increased mononuclear cell inltration, and necrosis in the defect group. In the defect + graft group, an increase in collagen ber, a decrease in inammatory cells, an increase in osteoblast cells and bone matrix were observed. As a result, allograft application has been found to support new bone formation in the calvarial defect model by creating an osteoinductive and osteoconductive effect.

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