scholarly journals Antimicrobial Effectiveness of a Highly Concentrated Chlorhexidine Varnish Treatment in Teenagers with Fixed Orthodontic Appliances

2006 ◽  
Vol 76 (6) ◽  
pp. 1022-1027 ◽  
Author(s):  
Rengin Attin ◽  
Anika Ilse ◽  
Carola Werner ◽  
Annette Wiegand ◽  
Thomas Attin
Keyword(s):  
Repeated Measures ◽  
Healthy Subjects ◽  
Statistical Significance ◽  
Mutans Streptococci ◽  
Orthodontic Appliances ◽  
Repeated Measures Design ◽  
Tooth Cleaning ◽  
Fixed Orthodontic Appliances ◽  
Baseline Values ◽  
Antimicrobial Effectiveness

Abstract Objective: To evaluate the recolonization pattern of Mutans streptococci (ms) on densely colonized teeth with fixed orthodontic appliances after treatment with a highly concentrated (36%) chlorhexidine varnish. Materials and Methods: Healthy subjects (n = 19) with fixed orthodontic appliances and high bacterial ms counts in saliva were recruited. In order to establish a baseline registration, plaque adjacent to brackets was sampled and cultivated on Dentocult® strips. Following professional tooth cleaning, chlorhexidine varnish was applied on all teeth for 8 minutes. The degree of recolonization with ms was assessed 2 weeks after varnish application in plaque around the brackets. For statistical analysis, the data were subjected to a repeated measures design. Results: After 2 weeks, ms counts were reduced as compared to baseline values. However, the reduction only weakly met statistical significance (P = .049). Conclusions: The application of a highly concentrated chlorhexidine varnish in patients with fixed orthodontic appliances does not result in a distinct reduction of ms numbers 2 weeks after treatment.

scholarly journals Effect of fixed orthodontic appliances on nonmicrobial salivary parameters

2018 ◽  
Vol 88 (6) ◽  
pp. 806-811 ◽  
Author(s):  
Ioannis P. Zogakis ◽  
Erez Koren ◽  
Shlomit Gorelik ◽  
Isaac Ginsburg ◽  
Miriam Shalish
Keyword(s):  
Orthodontic Treatment ◽  
Statistical Significance ◽  
Orthodontic Appliances ◽  
Inclusion Criteria ◽  
Reactive Protein ◽  
Fixed Orthodontic Appliances ◽  
Salivary Ph ◽  
Orthodontic Patients ◽  
The Difference ◽  
Ph Decrease

ABSTRACT Objectives: To examine possible changes in the levels of salivary antioxidants, C-reactive protein (CRP), cortisol, pH, proteins, and blood in patients treated with fixed orthodontic appliances. Materials and Methods: Salivary samples from 21 orthodontic patients who met specific inclusion criteria were collected before the beginning of orthodontic treatment (T0; baseline), 1 hour after bonding (T1), and 4–6 weeks after bonding (T2). Oxidant-scavenging ability (OSA) was quantified using a luminol-dependent chemiluminescence assay. Cortisol and CRP levels were measured using immunoassay kits. pH levels and presence of proteins and blood in the samples were quantified using strip-based tests. Results: A significant decrease in salivary pH was observed after bonding (P = .013). An increase in oxidant-scavenging abilities during orthodontic treatment was detected, but the change was not statistically significant. Cortisol and CRP levels slightly increased after bonding, but the difference was small without statistical significance. Changes in the presence of proteins and blood were also insignificant. Conclusions: Exposure to fixed orthodontic appliances did not show a significant effect on salivary parameters related to inflammation or stress, with the exception of a significant but transient pH decrease after bonding.

scholarly journals MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

2018 ◽  
Author(s):  
Maria Angeles Jimenez-Sousa ◽  
Ana Zaida Gómez-Moreno ◽  
Daniel Pineda-Tenor ◽  
Oscar Brochado-Kith ◽  
Juan José Sánchez-Ruano ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Repeated Measures ◽  
Injection Drug Users ◽  
Transient Elastography ◽  
Statistical Significance ◽  
Critical Role ◽  
Liver Stiffness ◽  
Pegylated Interferon ◽  
Repeated Measures Design ◽  
Fibrosis Progression

Background: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. Methods: We performed a retrospective study (repeated measures design) in 208 patients who had liver stiffness measurement (LSM), which was assessed by transient elastography No patient had cirrhosis at baseline (LSM≥12.5 kPa). Results: At baseline, 53.8% were male, the median age was 47.1 years, 13.5% reported a high intake of alcohol, 10.1% were prior injection drug users, 85.3% were infected by HCV genotype 1, and 22.6% had previously failed antiviral therapy (pegylated-interferon-alpha/ribavirin). During a median follow-up of 46.6 months, 26 patients developed cirrhosis. The rs4374383 G carriers had a higher risk of increasing LSM (adjusted arithmetic mean ratio (aAMR)=1.14; p=0.006) and a higher likelihood of having an increase in LSM greater than 5 kPa (ΔLSM≥5 kPa) [adjusted odds ratio (aOR)=2.37; p=0.029], and greater than 7 kPa (ΔLSM≥7 kPa) [aOR=3.24; p=0.032], after controlling for confounding. The SNP’s association with cirrhosis progression was close to statistical significance (aOR=2.18; p=0.070). Conclusions: MERTK rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients.

scholarly journals Molecular weight of barley β-glucan influences energy expenditure, gastric emptying and glycaemic response in human subjects

2013 ◽  
Vol 110 (12) ◽  
pp. 2173-2179 ◽  
Author(s):  
P. S. Thondre ◽  
A. Shafat ◽  
M. E. Clegg
Keyword(s):  
Molecular Weight ◽  
Gastric Emptying ◽  
Repeated Measures ◽  
Healthy Subjects ◽  
Human Subjects ◽  
Glycaemic Response ◽  
Molecular Weights ◽  
Repeated Measures Design ◽  
Diet Induced Thermogenesis ◽  
Single Blind

Barley β-glucan (BG) has been shown to reduce glycaemic response (GR) in some studies. It is hypothesised that this reduction may be a function of its physical properties that delay gastric emptying (GE). The effect of these changes in GR and GE on diet-induced thermogenesis (DIT) is not known. The aim of the present study was to assess the effect of BG of different molecular weights and purities on GR, GE and DIT in healthy subjects. This was a randomised, single-blind, repeated-measures design where fifteen healthy subjects were tested on three occasions following an overnight fast. Following the baseline measurements, the volunteers were fed a soup containing high-molecular-weight BG (HBG), a soup containing low-molecular-weight BG (LBG) or a control soup with no BG (CHO). Following the consumption of the breakfast, GR was measured using finger-prick blood samples, GE was determined using the 13C-octanoic acid breath test and DIT was measured using indirect calorimetry. There was a difference in GR AUC between the soups after 60 min but not after 120 min. The CHO and LBG meals had a greater GR than the HBG meal. There were differences in all GE time points, with the HBG meal having the slowest GE time. There was a correlation between the GR and the initial GE times. There were differences in total DIT between the three test meals with the HBG meal having the lowest DIT. The present study indicates that HBG has the ability to delay GE due to increased viscosity, resulting in a decreased GR and DIT.

The cognitive and behavioral impact of a culinary education program on schoolchildren

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Nur Al Ali ◽  
Andres Arriaga ◽  
Margarita Rubio
Keyword(s):  
Diet Quality ◽  
Education Program ◽  
Repeated Measures ◽  
Statistical Power ◽  
Statistical Significance ◽  
Control Group ◽  
Content Type ◽  
Repeated Measures Design ◽  
The Mean ◽  
Culinary Education

Purpose The purpose of this paper is to design a culinary education program and ascertain its impact on knowledge, phobias, culinary skills and diet quality in schoolchildren. Design/methodology/approach Repeated measures design to determine changes after the implementation of the culinary education program in a pre-school and primary school located in a Madrid (Spain) neighborhood with a low socioeconomic level. A total of 58 children agreed to participate in the program and 40 parents authorized the evaluation of the effect of the program. Variables were measured with Student’s t-test or Wilcoxon-signed range test for quantitative variables. Effect size was calculated by Cohen’s d. Findings The mean scores in knowledge and beliefs improved from 5.0 to 7.8 (P < 0.001; Cohen’s d = 1), the mean value obtained in the food phobias test decreased from 24.6 to 20.7 (P = 0.01; Cohen’s d = 0.53), diet quality on Kid Med Test score increased from 7.4 to 8.2 (P = 0.06; Cohen’s d = 0.38), and the children improved their culinary skills from 21.2 to 27.9 (P < 0.001; Cohen’s d = 0.66). Research limitations/implications Self-declared data could lead to information biases. Other limitations were the lack of control group and a scarce statistical power that could explain the absence of statistical significance in the results on diet quality. To observe the effects of this change on eating habits, long-term evaluations would have to be carried out. Originality/value The brand-new culinary education program had a positive effect on children’s knowledge of nutrition and culinary skills as well as reducing food phobias. This proposal is beyond the state-of-the-art and could be implemented elsewhere with a robust effect on children, parents and educators.

scholarly journals Effectiveness of a motionless ultrasonic toothbrush in reducing plaque and gingival inflammation in patients with fixed orthodontic appliances

2016 ◽  
Vol 87 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Thayika Saruttichart ◽  
Pintu-on Chantarawaratit ◽  
Chalermpol Leevailoj ◽  
Panida Thanyasrisung ◽  
Waranuch Pitiphat ◽  
...  
Keyword(s):  
Mutans Streptococci ◽  
Plaque Index ◽  
Orthodontic Appliances ◽  
Gingival Inflammation ◽  
Fixed Orthodontic Appliances ◽  
Significant Difference ◽  
Before And After ◽  
Orthodontic Patients ◽  
Manual Toothbrush ◽  
Better Than

ABSTRACT Objective: To compare the effectiveness of a motionless ultrasonic toothbrush to a manual toothbrush in reducing dental plaque, gingival inflammation, and mutans streptococci in patients with fixed orthodontic appliances. Materials and Methods: Twenty-five orthodontic patients were recruited to this crossover study. The patients were randomized into two groups starting with manual or motionless ultrasonic toothbrushes for 30 days. After a 30-day washout period, the patients switched to the other toothbrush type for 30 days. Plaque and gingival indices were evaluated by two calibrated-blinded examiners before and after each 30-day period of brushing. Salivary samples were also collected for quantification of mutans streptococci. Results: On the bracket side, the motionless ultrasonic toothbrush showed a significantly higher mean plaque index bracket score after 30-day usage than baseline (P = .049), while the manual toothbrush group showed no difference between the before and after brushing periods (P = .10). The changes in plaque index bracket score were significantly more favorable in the manual toothbrush group than in the ultrasonic toothbrush group (P = .04). In contrast, no difference was observed on the nonbracket side. There was no significant difference in the changes of gingival index or the numbers of mutans streptococci between the two groups. Conclusion: Manual toothbrushing performed better than brushing with the motionless ultrasonic toothbrush in plaque removal on the bracket side in orthodontic patients. However, no difference was observed in terms of gingival status and the numbers of mutans streptococci.

Quantifying Bilateral Joint Contributions during Three Variations of the Step Exercise

2006 ◽  
Vol 15 (3) ◽  
pp. 254-265 ◽  
Author(s):  
Sean P. Flanagan ◽  
Kara M. Kessans ◽  
George J. Salem
Keyword(s):  
Lower Extremity ◽  
Repeated Measures ◽  
Healthy Subjects ◽  
Outcome Measure ◽  
Joint Torque ◽  
Biomechanical Analysis ◽  
Main Outcome Measure ◽  
Repeated Measures Design ◽  
Type Design ◽  
Step Down

Context:Information regarding how the mechanical demand differs with variants of the step exercise may be used by clinicians to more appropriately prescribe lower-extremity exercise.Objective:To quantify the joint torque contributions of the lower extremity during three different step exercises: forward step-up (FS), lateral step-up (LS), and step-down (SD).Design:An experiment with a repeated measures design.Setting:Biomechanics laboratory.Participants:18 healthy subjects (9 men, 9 women, age 25.67 ± 4.23 years, height 1.73 ± 0.10 meters, mass 72.73 ± 10.67 kilograms).Intervention:Participants performed three sets of three repetitions of each exercise while instrumented for biomechanical analysis.Main Outcome Measure:Mechanical effort of the hip, knee, and ankle of both limbs during each exercise.Results:The greatest contribution from the hip was required during the FS, while the contribution from the knee was required during the SD. The greatest contribution from the ankle was required during the LS and SD.Conclusion:Choice of step exercise results in different distributions of mechanical demand across the lower extremities.

scholarly journals Changes in subgingival microflora after placement and removal of fixed orthodontic appliances

2014 ◽  
Vol 142 (5-6) ◽  
pp. 301-305 ◽  
Author(s):  
Marija Zivkovic-Sandic ◽  
Branka Popovic ◽  
Jelena Carkic ◽  
Nadja Nikolic ◽  
Branislav Glisic
Keyword(s):  
Statistical Significance ◽  
Orthodontic Appliances ◽  
Fixed Orthodontic Appliances ◽  
Orthodontic Patients ◽  
Group A ◽  
Subgingival Microflora ◽  
Fixed Appliances ◽  
Pcr Method ◽  
Group B ◽  
The Right

Introduction. The placement of fixed orthodontic appliances may lead to increased plaque accumulation and changes in subgingival microflora. Objective. The aim of this study was to examine the changes in frequency of subgingival microflora that occur after placement and removal of fixed orthodontic appliance using polymerase chain reaction (PCR). Methods. This study included 33 orthodontic patients, who were divided into two groups. Subgingival plaque samples were collected from the right upper incisor (U1) and right upper first molar (U6). In group A, the samples were taken three times: before placement appliance (T1), after one month (T2), and after 3 months (T3). In group B the samples were also taken three times: before appliance removal (T1), after one month (T2), and after three months (T3). PCR method was used to determine the presence of P. gingivalis, A. actinomycetemcomitans, T. forsythia, and P. intermedia. Results. In group A the frequency of P. gingivalis showed statistically significant decrease at U1 (p=0.049) and U6 (p=0.008), from T1 to T2, and at U1 (p=0.048) from T1 to T3. In group B only the frequency of T. forsythia showed a statistically significant decrease, at U6 (T1 vs. T2, p=0.004; T1 vs. T3, p=0.0003). Regarding other analyzed bacteria, changes in the presence were noticed but no statistical significance was found. Conclusion. Placement of fixed appliances may have an impact on subgingival microflora, but in the first months after the placement and removal of the appliance changes were not significant, probably due to good oral hygiene.

scholarly journals Auriculotherapy used to manage orthodontic pain: a randomized controlled pilot study

2021 ◽  
Vol 26 (6) ◽  
Author(s):  
Emanuela SERRITELLA ◽  
Alessandra IMPELLIZZERI ◽  
Aldo LIGUORI ◽  
Gabriella GALLUCCIO
Keyword(s):  
Pain Treatment ◽  
Statistical Significance ◽  
T Test ◽  
Control Group ◽  
Orthodontic Appliances ◽  
Chi Square ◽  
Homogeneous Groups ◽  
Fixed Orthodontic Appliances ◽  
Orthodontic Pain ◽  
T1 And T2

ABSTRACT Introduction: Several methods are commonly used to decrease orthodontic pain, but versatile tools and standardized protocols are still lacking. Objective: In response to the need for alternatives to conventional analgesic methods, this study evaluates the analgesic effects of auriculotherapy (AT) during the first three months of fixed orthodontic treatment. Methods: A sample of 36 subjects was selected, with patients randomly allocated into two homogeneous groups, Study Group (SG) and Control Group (CG), depending on the application/non-application of AT. Patients rated their pain scores monthly from 0 to 10, on visual analogue scales (VAS) at the time of bonding (T0) and again at two appliance adjustments (T1 and T2). At each of these treatment phases, VAS was applied in six different time moments (TM): immediately before, immediately after, after 4 hours, after 8 hours, after 24 hours, and after 72h hours. Descriptive statistical analysis, a Student’s t-test, and a Chi-square test were applied to the collected data (statistical significance for p< 0.05). Results: SG patients reported lower pain levels than CG patients, both at T0, T1 and T2. Moreover, average pain intensity values were lower in the SG for all TM analyzed, with the t-test significant (p< 0.05) for most TMs. Conclusion: AT was effective in the pain treatment of patients with fixed orthodontic appliances. Further studies are needed with a sham control group to confirm the validity of these results.

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