A Framework Structure for Generation of Active Primitives using Programming by Demonstration

2011 ◽  
Author(s):  
Yunsick Sung ◽  
Daxing Jin ◽  
Kyungeun Cho ◽  
Kyhun Um
Keyword(s):  
Programming By Demonstration ◽  
Framework Structure

Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

2020 ◽  
Vol 17 (9) ◽  
pp. 1084-1101
Author(s):  
Tingjuan Wu ◽  
Xu Yao ◽  
Guan Wang ◽  
Xiaohe Liu ◽  
Hongfei Chen ◽  
...  
Keyword(s):  
Drug Design ◽  
Oleanolic Acid ◽  
Water Solubility ◽  
Future Application ◽  
The Novel ◽  
Pharmacological Effects ◽  
Framework Structure ◽  
Design And Synthesis ◽  
The Past ◽  
The Relationship

Background: Oleanolic Acid (OA) is a ubiquitous product of triterpenoid compounds. Due to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties, OA has attracted tremendous interest in the field of drug design and synthesis. Furthermore, many OA derivatives have been developed for ameliorating the poor water solubility and bioavailability. Objective: Over the past few decades, various modifications of the OA framework structure have led to the observation of enhancement in bioactivity. Herein, we focused on the synthesis and medicinal performance of OA derivatives modified on A-ring. Moreover, we clarified the relationship between structures and activities of OA derivatives with different functional groups in A-ring. The future application of OA in the field of drug design and development also was discussed and inferred. Conclusion: This review concluded the novel achievements that could add paramount information to the further study of OA-based drugs.

scholarly journals Sulphur Concretes of Framework Structure

2021 ◽  
Vol 1079 (5) ◽  
pp. 052001
Author(s):  
V Erofeev ◽  
L Yausheva ◽  
A Bulgakov
Keyword(s):  
Framework Structure

From AgCN Chains to a Fivefold Helix and a Fishnet-Shaped Framework Structure

2005 ◽  
Vol 44 (18) ◽  
pp. 2794-2797 ◽  
Author(s):  
Victoria Urban ◽  
Thorsten Pretsch ◽  
Hans Hartl
Keyword(s):  
Framework Structure

The crystal structure of zigrasite, MgZr(PO4)2(H2O)4, a heteropolyhedral framework structure

2010 ◽  
Vol 74 (3) ◽  
pp. 567-575 ◽  
Author(s):  
F. C. Hawthorne ◽  
W. B. Simmons
Keyword(s):  
Crystal Structure ◽  
Framework Structure ◽  
Heteropolyhedral Framework

AbstractThe crystal structure of zigrasite, ideally MgZr(PO4)2(H2O)4, a 5.3049(2), b 9.3372(4), c 9.6282(5) Å, α 97.348(1)°, β 91.534(1)°, γ 90.512(4)°, V 472.79(5) Å3, Z = 2, triclinic, P1, Dcalc. 2.66 g.cm–3, from the giant 1972 pocket at Newry, Oxford County, Maine, USA, has been solved and refined to R1 3.75% on the basis of 2623 unique reflections (Fo > 4σF). There are two P sites, each of which is solely occupied by P with <P–O> distances of 1.532 and 1.533 Å, respectively. There are two Mg sites, both of which are occupied by Mg and are octahedrally coordinated two O anions and four (H2O) groups with <Mg–O> distances of 2.064 and 2.075 Å, respectively. There is one Zr site, occupied by Zr and octahedrally coordinated by six O anions with a <Zr–O> distance of 2.065 Å . The (ZrO6) octahedron shares corners with six (PO4) tetrahedra, forminga [Zr(PO4)2] sheet parallel to (001). These sheets are stacked in the c direction and linked by (MgO2(H2O)4) octahedra that share O atoms with the (PO4) groups. The structure is formally a heteropolyhedral framework structure, but the linkage is weaker in the c direction, accounting for the marked (001) cleavage.

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