Complications of Diabetes Mellitus

2019 ◽  
Author(s):  
Samuel Dagogo-Jack
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Key Words ◽  
Diabetic Patients ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Vessel Disease ◽  
Key Words Hyperglycemia ◽  
Large Vessel Disease

The long-term complications of diabetes mellitus include those attributable to hyperglycemia-mediated small vessel (microvascular)and neuropathic complications and syndromes resulting from multifactorial large vessel disease (macrovascular complications). Diabetic patients with evidence of chronic complications are best managed in consultation with appropriate specialists. The microvascular and neuropathic complications, which are specifically related to hyperglycemia, include retinopathy, nephropathy, and diabetic neuropathy. This review contains 8 figures, 9 tables, and 83 references. Key Words: Hyperglycemia, hypoglycemia, macrovascular, microvascular, neuropathic

Complications of Diabetes Mellitus

2019 ◽  
Author(s):  
Samuel Dagogo-Jack
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Key Words ◽  
Diabetic Patients ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Vessel Disease ◽  
Key Words Hyperglycemia ◽  
Large Vessel Disease

The long-term complications of diabetes mellitus include those attributable to hyperglycemia-mediated small vessel (microvascular)and neuropathic complications and syndromes resulting from multifactorial large vessel disease (macrovascular complications). Diabetic patients with evidence of chronic complications are best managed in consultation with appropriate specialists. The microvascular and neuropathic complications, which are specifically related to hyperglycemia, include retinopathy, nephropathy, and diabetic neuropathy. This review contains 8 figures, 9 tables, and 83 references. Key Words: Hyperglycemia, hypoglycemia, macrovascular, microvascular, neuropathic

scholarly journals Long Term Complications of Diabetes – A Review

2014 ◽  
Vol 21 (4) ◽  
pp. 347-355
Author(s):  
Ionuţ Vlad ◽  
Dana Sonia Oieru ◽  
Amorin Remus Popa ◽  
Mihaela Zaharia
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Manifestations ◽  
Prevention Strategies ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Full Picture

Abstract It is estimated that subclinical DM (diabetes mellitus) has the onset about 10 years before the appearance of actual clinical manifestations, leading to uncontrolled chronic complications. Many trials have pursued the onset and evolution of the DM chronic complications in order to obtain a full picture that allows the development of prevention strategies, treatments and DM costs reduction.

scholarly journals Prospects for the management of diabetic neuropathy

2011 ◽  
Vol 14 (2) ◽  
pp. 70-73
Author(s):  
Alexandr Sergeevich Ametov ◽  
Marina Alexandrovna Lysenko
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Ppar Alpha ◽  
Chronic Complications ◽  
Alpha Receptors ◽  
Long Term Prognosis

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus leading to deterioration of the patientsquality of life. Effective methods for the treatment of DPN and improvement of both quality of life and long-term prognosis of the disease remain tobe developed.To review pathogenetic mechanisms of DPN, the known methods of DPN treatment and the influence of activation of PPAR-alpha receptors onpathogenesis and outcome of DPN.

scholarly journals ROLE OF SARVANGA UDVARTANA AND SARVANGA TAKRADHARA IN THE MANAGEMENT OF DIABETIC PERIPHERAL NEUROPATHY WITH SPECIAL REFERENCE TO MADHUMEHA: A CLINICAL STUDY

2021 ◽  
Vol 12 (1) ◽  
pp. 110-113
Author(s):  
S Jagadesh Kumar ◽  
Shreyas D M ◽  
Kiran M Goud
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Diabetic Patients ◽  
Diabetic Population ◽  
Sugar Levels ◽  
Chronic Hyperglycaemia

Diabetes mellitus is a global health problem of this era. Presently India is having the largest diabetic population of 50.8 million. In 2015, diabetes was the direct cause of 1.6 million deaths. Diabetes Mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrates, fat and protein metabolism resulting from defects in insulin secretion. Diabetes, particularly type 2 is associated with various long-term complications like Diabetic retinopathy, nephropathy, neuropathy, etc., Globally diabetic neuropathy affects approximately 132 million people as of 2010 (1.9% of population). There is a higher prevalence (60.4%) and incidence (8.76%) of sensory peripheral neuropathy among the observed diabetic patients. In Ayurveda, the symptoms of Diabetic neuropathy are explained under the headings of Purvaroopa and upadrava of Prameha. Madhumeha is a bahudrava shleshma condition. So, Sarvanga Udvartana and Sarvanga Takradhara is been adopted to counteract the Samprapti of Prameha. A minimum of 20 subjects who fulfilled the diagnostic and inclusion criteria was subjected to the intervention. The overall results in the study revealed statistically highly significant result after the treatment on reducing symptoms and blood sugar levels.

scholarly journals Az oxidatív stressz szerepe a diabeteses neuropathia kialakulásában

2016 ◽  
Vol 157 (49) ◽  
pp. 1939-1946 ◽  
Author(s):  
Ferenc Sztanek ◽  
Ágnes Molnárné Molnár ◽  
Zoltán Balogh
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Microvascular Complications ◽  
Advanced Glycation ◽  
Complications Of Diabetes ◽  
Kinase C ◽  
Glycation End Products ◽  
Comparative Trials

Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress. The development of modern medicines to treat diabetic neuropathy needs intensive long-term comparative trials in the future. Orv. Hetil., 2016, 157(49), 1939–1946.

scholarly journals A COMPREHENSIVE STUDY ON LITERATURE EVIDENCE, CLINICAL STUDIES AND PRACTICES OF HERBAL DRUGS FOR DIABETIC NEUROPATHY AND CARDIOMYOPATHY

2017 ◽  
Vol 10 (9) ◽  
pp. 30
Author(s):  
Arshiya Shamim ◽  
Hefazat Hussain Siddiqui ◽  
Tarique Mahmood ◽  
Paramdeep Bagga ◽  
Ranjan Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Diabetic Neuropathy ◽  
Diabetic Cardiomyopathy ◽  
Left Ventricular ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Epidemic Disease ◽  
Complications Of Diabetes ◽  
Wide Range

  Diabetes mellitus is a worldwide epidemic disease that eventually advances to a chronic stage and affects different vital organs by intensifying the underlying pathological factors, and through the remodeling of the tissues by the generation of reactive oxygen species leading to the development of respective organ failure. Two such complications are painful neuropathy and cardiomyopathy; both of which are common and progressive complications of diabetes. The symptoms of peripheral neuropathy include tingling, burning, lancinating pain, hyperesthesia, and allodynia. The course of the disease progression may vary from intermittent, mild symptoms to severe chronic, and daily pain; which culminates into poor quality of life. Another complication of diabetes mellitus, diabetic cardiomyopathy, is defined as a ventricular dysfunction disorder that occurs in diabetic patients. The development of the disease is characterized by a hidden subclinical period, during which cellular, structural changes and abnormalities lead to diastolic dysfunction, followed by systolic dysfunction, and terminating into heart failure. Left ventricular hypertrophy, metabolic abnormalities, extracellular matrix changes, small vessel disease, cardiac autonomic neuropathy, insulin resistance, oxidative stress, and apoptosis are the most important pathological advancements that lead to diabetic cardiomyopathy. Various pharmaceutical agents from different pharmacological categories have been proposed for the symptomatic treatment of painful diabetic neuropathy; however, it is a herculean task to select a drug due to the wide range of choices and lack of consistent guidelines for treatment. Similarly, treatment of cardiomyopathy is based on the general therapeutic rules of management of heart failure and no specifications have yet been addressed for this condition. Therefore, more studies are required to improve our knowledge of these complex syndromes. From this perspective, this review is designed to delineate a general overview of neuropathy and cardiomyopathy, referring to the conventional therapies in use and possible unconventional, natural, herbal, and safe treatments for both the above-mentioned complications of diabetes.

Effectiveness of mobile applications on healthy lifestyles aimed at diabetic patients: review of systematic reviews. (Preprint)

2019 ◽  
Author(s):  
Francisco Jesús Represas Carrera Sr ◽  
Ángel Alfredo Martínez Ques Sr ◽  
Ana Clavería Fontán Sr
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Systematic Reviews ◽  
Mobile Applications ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Lifestyles ◽  
Major Public Health Problem

BACKGROUND Diabetes mellitus is currently a major public health problem worldwide. It is traditionally approached in a clinical inpatient relationship between the patient and the healthcare professional. However, the rise of new technologies, particularly mobile applications, is revolutionizing the traditional healthcare model through the introduction of telehealthcare. OBJECTIVE (1) To assess the effects of mobile applications for improving healthy lifestyles on the quality of life and metabolic control of diabetes mellitus in adult patients. (2) To describe the characteristics of the mobile applications used, identify the healthy lifestyles they target, and describe any adverse effects their use may have. METHODS Review of systematic reviews and meta-analysis, following the guidelines of the Cochrane Collaboration and the Joanna Briggs Institute. We included studies that used any mobile application aimed at helping patients improve self-management of diabetes mellitus by focusing on healthy lifestyles. Studies needed to include a control group receiving regular care without the use of mobile devices. In May 2018, a search was conducted in Medline, Embase, Cochrane, LILACS, PsychINFO, Cinahl and Science Direct, updated in May 2019. The methodological quality of the studies was assessed using the Amstar-2 tool. RESULTS Seven systematic reviews of 798 articles were initially selected for analysis. The interventions had a duration of between 1 and 12 months. Mobile applications focused singly or simultaneously on different lifestyles aspects (diet, physical exercise, motivation, blood glucose levels, etc.). There are significant changes in HbA1c values, body weight and BMI, although in others, such as lipid profile, quality of life, or blood pressure, there is no clear improvement. CONCLUSIONS There is clear evidence that the use of mobile applications improves glycemic control in diabetic patients in the short term. There is a lack of evidence in its long-term benefits. It is thus necessary to carry out further studies to learn about the long-term effectiveness of mobile applications aimed at promoting the healthy lifestyles of diabetic patients. CLINICALTRIAL PROSPERO Register: CRD42019133685

Awareness of Complications in Diabetic Patients - Study in a Tertiary Care Centre in Kerala

2021 ◽  
Vol 8 (37) ◽  
pp. 3334-3338
Author(s):  
Satish Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tertiary Care ◽  
Diabetic Patients ◽  
Tertiary Care Centre ◽  
Type 2 Diabetic Patients ◽  
Complications Of Diabetes ◽  
Type 2 Diabetic

BACKGROUND Type 2 diabetes mellitus is common in the Indian population and awareness regarding the disease and its complications is low among the patients with diabetes. There is lack of studies regarding awareness of complications of diabetes among type 2 diabetic patients. The purpose of this study was to assess the awareness of diabetic complications among type 2 diabetic patients. METHODS This is an institutional based observational study. The sample comprised of 150 adult patients with type 2 diabetes mellitus who underwent treatment in the Department of Medicine, Medical College Kottayam and the patient’s age ranged from 18 - 77 years. RESULTS Majority of patients were in the age group 38 to 57 and the sample comprised of 56 % males and 44 % female patients. Out of 150 patients involved in the study, 120 patients (80 %) were aware of the complications of diabetes mellitus. Among the male patients, 70 (83.33 %) and among females, 50 (75.75 %) were aware of the complications in diabetes. In the study sample, 92 (61.33 %) were aware of the foot problems, 120 patients (80 %) were aware of renal complications, 91 patients were aware regarding eye problems of diabetes, 38 (25.33 %) regarding development of hypertension, 62 (41.33 %) regarding heart attack, 42 (28 %) patients were aware regarding development of stroke and 78 patients (52 %) had awareness regarding occurrence of recurrent infections. CONCLUSIONS Awareness regarding diabetes and its complications is fairly good among the diabetic patients in Kerala. Awareness regarding all complications of diabetes was higher among males than females. Providing awareness to type 2 diabetic patients by various educational programs may be of further help to prevent complications and to decrease the mortality and morbidity in type 2 diabetes patients. KEYWORDS Awareness, Diabetes

The nature of large vessel disease in diabetes mellitus

1990 ◽  
Vol 4 (2) ◽  
pp. 63-65 ◽  
Author(s):  
Thomas Ledet ◽  
Lars M. Rasmussen ◽  
Lene Heickendorff ◽  
Karen Barfod ◽  
Vibeke B. Thøgersen
Keyword(s):  
Diabetes Mellitus ◽  
Large Vessel ◽  
Vessel Disease ◽  
Large Vessel Disease
Sign in / Sign up

Export Citation Format

Share Document