Randomized, Double-Blind Comparison of the Efficacy of Two Hyaluronic Acid Derivatives, Restylane Perlane and Hylaform, in the Treatment of Nasolabial Folds

2005 ◽  
Vol 31 ◽  
pp. 1591-1598 ◽  
Author(s):  
Alastair Carruthers ◽  
Wayne Carey ◽  
Claudio Lorenzi ◽  
Kent Remington ◽  
Daniel Schachter ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Double Blind ◽  
Blind Comparison ◽  
Nasolabial Folds

scholarly journals A randomized, double-blind, comparative study for efficacy assessment of two hyaluronic acid nasolabial fillers

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Saman Ahmad Nasrollahi ◽  
Mansour Nassiri Kashani ◽  
Taraneh Yazdanparast ◽  
Setareh Ameri ◽  
Alireza Firooz
Keyword(s):  
Hyaluronic Acid ◽  
Safety Assessment ◽  
Clinical Signs ◽  
P Value ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Efficacy Assessment ◽  
Spss Software ◽  
Nasolabial Folds ◽  
Better Than

<p class="Default">Hyaluronic acid fillers are considered safe for use in cosmetics as described in the safety assessment. This study was aimed to assess and compare the efficacy and safety of two hyaluronic acid (HA) fillers on mild nasolabial folds. Ten women aged 30-50 years with mild nasolabial folds participated for injection of A and B gels into right or left nasolabial folds. The volume and surface of nasolabial folds were measured by CSI software and the density and thickness of dermis assessed by skin ultrasonography before and 2, 12, and 24 weeks after injection. The data were analyzed using SPSS software version 20, and p-value &lt;0.05 were considered as significant. Global assessment showed over 50% improvement in patients injected with both gel A and B. At 2 weeks after injecting gel A the volume and surface of wrinkles decreased significantly. In the side injected with gel B, this reduction was significant at 2 and 12 weeks after injection. In addition, 24 weeks after injection of both gels the dermis echo-density increased and the dermis thickness decreased.  This study indicated the significant positive filling effect of both HA fillers in decreasing the clinical signs of wrinkles at nasolabial folds. Comparing both fillers, there were not any statistically significant differences in any of measurements, but the persistence of gel B to improve the wrinkle appearance was slightly better than gel A. </p>

Efficacy and Durability of Two Hyaluronic Acid-Based Fillers in the Correction of Nasolabial Folds: Results of a Prospective, Randomized, Double-Blind, Actively Controlled Clinical Pilot Study

2011 ◽  
Vol 37 (6) ◽  
pp. 768-775 ◽  
Author(s):  
ALEXANDER NAST ◽  
NATALIE REYTAN ◽  
VANESSA HARTMANN ◽  
DELANO PATHIRANA ◽  
FRANK BACHMANN ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Pilot Study ◽  
Double Blind ◽  
Nasolabial Folds
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