scholarly journals Antibody Response to Booster Dose of Diphtheria and Tetanus Toxoids: Reactions in Institutionalized Adults and Non-Institutionalized Children and Young Adults

1963 ◽  
Vol 78 (2) ◽  
pp. 161 ◽  
Author(s):  
V. K. Volk ◽  
R. Y. Gottshall ◽  
H. D. Anderson ◽  
Franklin H. Top ◽  
W. E. Bunney ◽  
...  
Keyword(s):  
Young Adults ◽  
Antibody Response ◽  
Booster Dose ◽  
Institutionalized Children ◽  
Children And Young Adults

COMMITTEE ON CONTROL OF INFECTIOUS DISEASES

PEDIATRICS ◽  
1960 ◽  
Vol 26 (2) ◽  
pp. 331-332
Author(s):  
◽  
Lewis L. Coriell ◽  
John H. Dent ◽  
Horace L. Hodes ◽  
C. Henry Kempe ◽  
...  
Keyword(s):  
Young Adults ◽  
Antibody Response ◽  
Preliminary Evidence ◽  
Considerable Proportion ◽  
Inactivated Vaccine ◽  
Older Children ◽  
Poliomyelitis Vaccine ◽  
Epidemic Area ◽  
Children And Young Adults ◽  
Children Under 5

Immunization with formaldehyde-inactivated vaccine is recommended for all children and young adults. The course recommended earlier was two 1-ml intramuscular injections (1 month apart) followed by a third 1-ml injection (after an interval of approximately 7 months). This is probably adequate for older children and adults. Preliminary evidence indicates that a considerable proportion of infants have a less than optimal or relatively short-lived antibody response when immunized in this fashion. Vaccination of infants should be started at about 1½ to 2 months of age. The Committee recommends that children under 5 years of age be given a series of three 1-mi injections (1 month apart) followed by a fourth injection (up to 8 months later) and then a fifth injection (at about 4 yearsof age). In the present state of knowledge, additional injections seem advisable as indicated in Table I. A recall injection should be given before traveling abroad or before entering an epidemic area. Preparations containing inactivated poliovirus vaccine combined with diphtheria and tetanus toxoids and pertussis bacilli are now available. Such quadruple preparations should be given according to the manufacturer's directions, in general adhering to the schedule presently used for DPT (see Table I). For reasons of safety and to avoid possible loss of antigenic potency, it is considered advisable for physicians not to improvise mixtures of combined diphtheria, pertussis, and tetanus antigens and poliomyelitis vaccine. See table in the PDF file There are few contraindications to poliomyelitis vaccination. It may be performed safely at any time of the year, even when poliomyelitis is prevalent.

scholarly journals A study of the specific IgM antibody response inMycoplasma pneumoniaeinfection in man

1983 ◽  
Vol 90 (2) ◽  
pp. 207-211 ◽  
Author(s):  
P. Chamberlain ◽  
A. A. Saeed
Keyword(s):  
Young Adults ◽  
Antibody Response ◽  
Older Patients ◽  
Primary Infection ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Diagnostic Technique ◽  
Igm Antibody ◽  
Children And Young Adults

SUMMARYSera from 96 patients withMycoplasma pneumoniaeinfection were examined for specific IgM antibody. The complement fixation test was used to measure the IgM after separation by ultracentrifugation through sucrose density gradients. Of patients under the age of 20 years 78 % displayed positive specific IgM titres. In older patients only 34% were IgM positive. The specific IgM remained detectable, but at decreasing levels, during the follow-up period of 5 months. This diagnostic technique appears to be of value in children and young adults experiencing primary infection withM. pneumoniae.

scholarly journals Dynamics of the Antibody Response After a Third Dose of Measles-Mumps-Rubella Vaccine Indicate a Slower Decline Compared With a Second Dose

2020 ◽  
Vol 7 (11) ◽  
Author(s):  
Patricia Kaaijk ◽  
M Alina Nicolaie ◽  
Debbie van Rooijen ◽  
Marianne A van Houten ◽  
Fiona R van der Klis ◽  
...  
Keyword(s):  
Young Adults ◽  
Antibody Response ◽  
Decay Rates ◽  
Igg Antibody ◽  
Rubella Vaccine ◽  
Blood Samples ◽  
Children And Young Adults ◽  
Antibody Levels ◽  
Induced Immunity

Abstract Background Breakthrough infections of measles and mumps have raised concerns about the duration of vaccine-induced immunity, which might be improved by a third dose of measles-mumps-rubella vaccine (MMR3). Methods Here we compared (IgG) antibody levels against measles, mumps, and rubella in blood samples of 9-year-old children and young adults (18–25 years) following MMR2 and MMR3, respectively. Results We found that, in addition to antibody boosting for all 3 vaccine components, MMR3 resulted in lower antibody decay rates than MMR2; the declines were most prominent for mumps and rubella. Conclusions This study suggests that MMR3 provides long-lasting seroprotection against measles, mumps, and rubella.

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