Brain Reaction in Guinea Pigs Infected with Endemic Typhus, Epidemic (European) Typhus, and Rocky Mountain Spotted Fever, Eastern and Western Types

1936 ◽  
Vol 51 (38) ◽  
pp. 1293 ◽  
Author(s):  
R. D. Lillie ◽  
R. E. Dyer
Keyword(s):  
Guinea Pigs ◽  
Spotted Fever ◽  
Rocky Mountain ◽  
Rocky Mountain Spotted Fever ◽  
Endemic Typhus ◽  
Brain Reaction

scholarly journals MORPHOLOGICAL STRUCTURE OF RICKETTSIAE

1943 ◽  
Vol 77 (4) ◽  
pp. 355-358 ◽  
Author(s):  
Harry Plotz ◽  
Joseph E. Smadel ◽  
Thomas F. Anderson ◽  
Leslie A. Chambers
Keyword(s):  
Vaccinia Virus ◽  
Q Fever ◽  
Spotted Fever ◽  
Morphological Structure ◽  
Rocky Mountain ◽  
Rocky Mountain Spotted Fever ◽  
Dense Granules ◽  
Endemic Typhus ◽  
Typhus Fever

The morphological structures of the rickettsiae of epidemic and endemic typhus fever, Rocky Mountain spotted fever, and Q fever are similar to one another and to certain bacteria. The rickettsial organisms in common with the elementary bodies of vaccinia virus and all bacteria would appear to have a limiting membrane which surrounds a substance that seems to be protoplasmic in nature; numbers of dense granules are embedded in the inner protoplasm.

scholarly journals STUDIES ON TYPHUS FEVER

1931 ◽  
Vol 53 (4) ◽  
pp. 493-497 ◽  
Author(s):  
Hans Zinsser ◽  
M. Ruiz Castaneda
Keyword(s):  
Guinea Pigs ◽  
Spotted Fever ◽  
Rocky Mountain ◽  
Active Immunization ◽  
Rocky Mountain Spotted Fever ◽  
Typhus Fever

Guinea pigs can be immunized against Mexican typhus virus by peritoneal injections of formalinized Rickettsia material, provided sufficient amounts of the organisms are used. Our results in this respect are analogous to those of Spencer and Parker with carbolized virus of Rocky Mountain spotted fever. The Rickettsia suspensions appear to possess considerable toxicity. We do not wish to be misunderstood as implying that the results in guinea pigs offer anything more than a demonstration of the principle of active immunization with killed Rickettsiae. Application to man will have to be worked out, and preliminary to this, we are now attempting to apply the methods to a limited number of monkeys.

scholarly journals IMMUNITY STUDIES OF ROCKY MOUNTAIN SPOTTED FEVER

1923 ◽  
Vol 38 (5) ◽  
pp. 605-626 ◽  
Author(s):  
Hideyo Noguchi
Keyword(s):  
Experimental Infection ◽  
Guinea Pigs ◽  
Spotted Fever ◽  
Rocky Mountain ◽  
Rabbit Serum ◽  
Normal Rabbit Serum ◽  
Rocky Mountain Spotted Fever ◽  
Refrigerator Temperature ◽  
Considerable Loss ◽  
Immune Rabbit

Freshly prepared mixtures of spotted fever virus and immune rabbit serum in neutral or superneutral proportions confer complete immunity on guinea pigs. The mixtures undergo a considerable loss in immunizing power when heated to 60°C. for 20 minutes, but are still capable, if used in sufficient quantity, of conferring a degree of immunity on the vaccinated animal such that a subsequent experimental infection is rendered less severe and non-fatal. Unheated mixtures which had been preserved in the refrigerator at 4°C. for a period of 32 days still retained a certain degree of immunizing property. The virus alone, or mixed with normal rabbit serum, when allowed to die out by prolonged preservation at refrigerator temperature, or when killed either by heating at 60°C. for 20 minutes or by chemicals (chloroform, ether, xylene) does not induce immunity in guinea pigs.

scholarly journals Serological Varieties of Typhus Fever

1931 ◽  
Vol 31 (2) ◽  
pp. 225-246 ◽  
Author(s):  
A. Felix ◽  
M. Rhodes
Keyword(s):  
Spotted Fever ◽  
Rocky Mountain ◽  
The United States ◽  
Antigenic Relationship ◽  
Rocky Mountain Spotted Fever ◽  
Antigenic Variant ◽  
Serological Type ◽  
Endemic Typhus ◽  
Typhus Fever ◽  
Source Of Error

1. Fletcher and Lesslar's observations on two serological types of tropical typhus have been fully confirmed.2. The antigenic relationship between the indologenicB. proteusX 19 and the non-indologenic Kingsbury strain is of the same order as that obtaining between the X 19 and X 2 types ofB. proteusX.3. The Kingsbury strain is an antigenic variant derived from the original X 19 culture and represents another serological type ofB. proteusX. The symbol XK is suggested for this type.4. Sera from cases of classical European typhus and of endemic typhus of the United States of America and of Australia have been tested for the occurrence of main and group O agglutinins for the known types ofB. proteusX.5. H agglutination as source of error in the diagnosis of typhus cases is illustrated by some examples.6. Sera from cases of tsutsugamushi from Sumatra and Japan react with type XK like the Malayan cases of this disease described by Fletcher and co-workers.7. This latter reaction is of the order of group O agglutination. It is suggested that antigenically the virus of tsutsugamushi corresponds to another serological type ofB. proteusX which is yet unknown.8. The data published on the serum reactions in Rocky Mountain spotted fever and in the “fièvre exanthématique” of Marseilles are analysed. It is suggested that these two diseases represent further serological varieties of typhus.9. The significance hitherto attached to negative agglutination tests withB. proteusX and to negative cross-immunity tests obtained with some typhuslike diseases requires revision in the light of recent observations.

Sign in / Sign up

Export Citation Format

Share Document