The Biological Effectiveness of Radon-Progeny Alpha Particles. V. Comparison of Oncogenic Transformation by Accelerator-Produced Monoenergetic Alpha Particles and by Polyenergetic Alpha Particles from Radon Progeny

1996 ◽  
Vol 146 (1) ◽  
pp. 75 ◽  
Author(s):  
Richard C. Miller ◽  
Marcia Richards ◽  
David J. Brenner ◽  
Eric J. Hall ◽  
Rick Jostes ◽  
...  
Keyword(s):  
Alpha Particles ◽  
Radon Progeny ◽  
Oncogenic Transformation ◽  
Biological Effectiveness

The Biological Effectiveness of Radon-Progeny Alpha Particles. II. Oncogenic Transformation as a Function of Linear Energy Transfer

1995 ◽  
Vol 142 (1) ◽  
pp. 54 ◽  
Author(s):  
Richard C. Miller ◽  
Stephen A. Marino ◽  
David J. Brenner ◽  
Stewart G. Martin ◽  
Marcia Richards ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Alpha Particles ◽  
Radon Progeny ◽  
Oncogenic Transformation ◽  
Biological Effectiveness

The Biological Effectiveness of Radon-Progeny Alpha Particles. III. Quality Factors

1995 ◽  
Vol 142 (1) ◽  
pp. 61 ◽  
Author(s):  
D. J. Brenner ◽  
R. C. Miller ◽  
Y. Huang ◽  
E. J. Hall
Keyword(s):  
Alpha Particles ◽  
Radon Progeny ◽  
Quality Factors ◽  
Biological Effectiveness

Oncogenic Transformation of C3H 10T1/2 Cells Exposed to Alpha Particles: Sensitivity through the Cell Cycle

1995 ◽  
Vol 142 (3) ◽  
pp. 276 ◽  
Author(s):  
D. Bettega ◽  
P. Calzolari ◽  
A. Costa ◽  
G. Noris Chiorda ◽  
L. Tallone
Keyword(s):  
Cell Cycle ◽  
Alpha Particles ◽  
Oncogenic Transformation

Recoil proton, alpha particle, and heavy ion impacts on microdosimetry and RBE of fast neutrons: analysis of kerma spectra calculated by Monte Carlo simulation

2001 ◽  
Vol 79 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Jean-Philippe Pignol ◽  
Jakobus Slabbert
Keyword(s):  
Monte Carlo ◽  
Recoil Proton ◽  
Clinical Results ◽  
Heavy Ion ◽  
Alpha Particles ◽  
Fast Neutrons ◽  
Monte Carlo Code ◽  
Powerful Method ◽  
Biological Effectiveness

Fast neutrons (FN) have a higher radio-biological effectiveness (RBE) compared with photons, however the mechanism of this increase remains a controversial issue. RBE variations are seen among various FN facilities and at the same facility when different tissue depths or thicknesses of hardening filters are used. These variations lead to uncertainties in dose reporting as well as in the comparisons of clinical results. Besides radiobiology and microdosimetry, another powerful method for the characterization of FN beams is the calculation of total proton and heavy ion kerma spectra. FLUKA and MCNP Monte Carlo code were used to simulate these kerma spectra following a set of microdosimetry measurements performed at the National Accelerator Centre. The calculated spectra confirmed major classical statements: RBE increase is linked to both slow energy protons and alpha particles yielded by (n,α) reactions on carbon and oxygen nuclei. The slow energy protons are produced by neutrons having an energy between 10 keV and 10 MeV, while the alpha particles are produced by neutrons having an energy between 10 keV and 15 MeV. Looking at the heavy ion kerma from <15 MeV and the proton kerma from neutrons <10 MeV, it is possible to anticipate y* and RBE trends.Key words: fast neutron, kerma, microdosimetry, RBE, Monte Carlo.

Sign in / Sign up

Export Citation Format

Share Document