Long-Term Effects of Prenatal Exposure to Low Levels of Gamma Rays on Open-Field Activity in Male Mice

1995 ◽  
Vol 144 (2) ◽  
pp. 237 ◽  
Author(s):  
Takeru Minamisawa ◽  
Kouichi Hirokaga
Keyword(s):  
Open Field ◽  
Prenatal Exposure ◽  
Gamma Rays ◽  
Male Mice ◽  
Long Term Effects ◽  
Open Field Activity ◽  
Field Activity ◽  
Low Levels

Prenatal exposure to benzodiazepine—I. Prenatal exposure to lorazepam in mice alters open-field activity and GABAA receptor function

1991 ◽  
Vol 30 (1) ◽  
pp. 53-58 ◽  
Author(s):  
S. Chesley ◽  
M. Lumpkin ◽  
A. Schatzki ◽  
W.R. Galpern ◽  
D.J. Greenblatt ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Open Field ◽  
Prenatal Exposure ◽  
Receptor Function ◽  
Open Field Activity ◽  
Field Activity

scholarly journals Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

Endocrinology ◽  
2003 ◽  
Vol 144 (1) ◽  
pp. 230-239 ◽  
Author(s):  
Sonoko Ogawa ◽  
Johnny Chan ◽  
Jan-Åke Gustafsson ◽  
Kenneth S. Korach ◽  
Donald W. Pfaff
Keyword(s):  
Locomotor Activity ◽  
Open Field ◽  
Home Cage ◽  
Placebo Control ◽  
Male Mice ◽  
Open Field Activity ◽  
Running Wheel ◽  
Field Activity ◽  
Wheel Activity ◽  
Estrogenic Regulation

Abstract Estrogens are known to increase running wheel activity of rodents primarily by acting on the medial preoptic area (mPOA). The mechanisms of this estrogenic regulation of running wheel activity are not completely understood. In particular, little is known about the separate roles of two types of estrogen receptors, ERα and ERβ, both of which are expressed in mPOA neurons. In the present study the effects of continuous estrogen treatment on running wheel activity were examined in male and female mice specifically lacking either the ERα (αERKO) or the ERβ (βERKO) gene. Mice were gonadectomized and 1 wk later implanted with either a low dose (16 ng/d) or a high dose (160 ng/d) of estradiol benzoate (EB) or with a placebo control pellet. Home cage running wheel activity was recorded for 9 d starting 10 d after EB implants. The same mice were also tested for open field activity before and after EB implants. In both female and male αERKO mice, running wheel activity was not different from that in corresponding wild-type (αWT) mice in placebo control groups. In both females and males it was increased by EB only in αWT, not αERKO, mice. In βERKO mice, on the other hand, both doses of EB equally increased running wheel activity in both sexes just as they did in βWT mice. Absolute numbers of daily revolutions of EB-treated groups, however, were significantly lower in βERKO females compared with βWT females. Before EB treatment, gonadectomized αERKO female were significantly less active than αWT mice in open field tests, whereas βERKO females tended to be more active than βWT mice. In male mice there were no effect of ERα or ERβ gene knockout on open field activity. Unlike its effect on running wheel activity, EB treatment induced only a small increase in open field activity in female, but not male, mice. These findings indicate that 1) in both sexes estrogenic regulation of running wheel activity is primarily mediated through the ERα, not the ERβ; and 2) hormone/genotype effects are specific to the type of locomotor activity (i.e. home cage running wheel activity and open field activity) measured.

Prenatal exposure to cocaine II: Effects on open-field activity and cognitive behavior in Sprague-Dawley rats

1992 ◽  
Vol 14 (5) ◽  
pp. 343-349 ◽  
Author(s):  
Josephine M. Johns ◽  
Michael J. Means ◽  
Deborah R. Anderson ◽  
Larry W. Means ◽  
Brian A. Mcmillen
Keyword(s):  
Open Field ◽  
Prenatal Exposure ◽  
Cognitive Behavior ◽  
Sprague Dawley ◽  
Open Field Activity ◽  
Sprague Dawley Rats ◽  
Field Activity

Prenatal Exposure to an ELF Rotating Magnetic Field, Ambulatory Behavior, and Lunar Distance at Birth: A Correlation

1971 ◽  
Vol 28 (2) ◽  
pp. 435-438 ◽  
Author(s):  
Michael A. Persinger
Keyword(s):  
Magnetic Field ◽  
Open Field ◽  
Prenatal Exposure ◽  
Prenatal Development ◽  
Rotating Magnetic Field ◽  
Open Field Activity ◽  
Field Situation ◽  
Field Activity ◽  
The Relationship

A significant correlation of 877 between lunar distance at the time of birth and the number of squares traversed in a open-field situation 21 to 25 days later was found for 19 litters that had been exposed continuously during their prenatal development to a 0.5 Hz, 3 to 30 gauss Rotating Magnetic Field (RMF), over a year. RMF-exposed litters that were born on or near lunar perigees traversed fewer squares in an open field than those born on or near apogees. RMF-exposed litters tested “blind” also showed the relationship between lunar distance at time of birth and later open-field activity. 12 control litters did not show a significant correlation (.101).

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Sign in / Sign up

Export Citation Format

Share Document