scholarly journals Long-Term Changes in Open Field Activity of Male Mice Irradiated with Low Levels of Gamma Rays at Late Stage of Development.

1996 ◽  
Vol 37 (2) ◽  
pp. 117-124 ◽  
Author(s):  
TAKERU MINAMISAWA ◽  
KOUICHI HIROKAGA
Keyword(s):  
Open Field ◽  
Gamma Rays ◽  
Late Stage ◽  
Male Mice ◽  
Open Field Activity ◽  
Stage Of Development ◽  
Field Activity ◽  
Long Term Changes ◽  
Low Levels

scholarly journals Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

Endocrinology ◽  
2003 ◽  
Vol 144 (1) ◽  
pp. 230-239 ◽  
Author(s):  
Sonoko Ogawa ◽  
Johnny Chan ◽  
Jan-Åke Gustafsson ◽  
Kenneth S. Korach ◽  
Donald W. Pfaff
Keyword(s):  
Locomotor Activity ◽  
Open Field ◽  
Home Cage ◽  
Placebo Control ◽  
Male Mice ◽  
Open Field Activity ◽  
Running Wheel ◽  
Field Activity ◽  
Wheel Activity ◽  
Estrogenic Regulation

Abstract Estrogens are known to increase running wheel activity of rodents primarily by acting on the medial preoptic area (mPOA). The mechanisms of this estrogenic regulation of running wheel activity are not completely understood. In particular, little is known about the separate roles of two types of estrogen receptors, ERα and ERβ, both of which are expressed in mPOA neurons. In the present study the effects of continuous estrogen treatment on running wheel activity were examined in male and female mice specifically lacking either the ERα (αERKO) or the ERβ (βERKO) gene. Mice were gonadectomized and 1 wk later implanted with either a low dose (16 ng/d) or a high dose (160 ng/d) of estradiol benzoate (EB) or with a placebo control pellet. Home cage running wheel activity was recorded for 9 d starting 10 d after EB implants. The same mice were also tested for open field activity before and after EB implants. In both female and male αERKO mice, running wheel activity was not different from that in corresponding wild-type (αWT) mice in placebo control groups. In both females and males it was increased by EB only in αWT, not αERKO, mice. In βERKO mice, on the other hand, both doses of EB equally increased running wheel activity in both sexes just as they did in βWT mice. Absolute numbers of daily revolutions of EB-treated groups, however, were significantly lower in βERKO females compared with βWT females. Before EB treatment, gonadectomized αERKO female were significantly less active than αWT mice in open field tests, whereas βERKO females tended to be more active than βWT mice. In male mice there were no effect of ERα or ERβ gene knockout on open field activity. Unlike its effect on running wheel activity, EB treatment induced only a small increase in open field activity in female, but not male, mice. These findings indicate that 1) in both sexes estrogenic regulation of running wheel activity is primarily mediated through the ERα, not the ERβ; and 2) hormone/genotype effects are specific to the type of locomotor activity (i.e. home cage running wheel activity and open field activity) measured.

The ethanol-induced open-field activity in rodents treated with isethionic acid, a central metabolite of taurine

Life Sciences ◽  
1999 ◽  
Vol 64 (18) ◽  
pp. 1613-1621 ◽  
Author(s):  
Marta Miquel ◽  
Mercé Correa ◽  
Carles Sanchis-Segura ◽  
Carlos M.G. Aragon
Keyword(s):  
Open Field ◽  
Open Field Activity ◽  
Field Activity ◽  
Isethionic Acid

An open-field activity analysis of labyrinthectomized rats

1990 ◽  
Vol 48 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Jennifer D. Porter ◽  
Sergio M. Pellis ◽  
Merle E. Meyer
Keyword(s):  
Open Field ◽  
Activity Analysis ◽  
Open Field Activity ◽  
Field Activity
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