Ionizing Radiation Induces Two Forms of Interphase Chromosome Breaks in Chinese Hamster Ovary Cells That Rejoin with Different Kinetics and Show Different Sensitivity to Treatment in Hypertonic Medium or β-araA

1993 ◽  
Vol 136 (2) ◽  
pp. 262 ◽  
Author(s):  
Ryuichi Okayasu ◽  
George Iliakis
Keyword(s):  
Ionizing Radiation ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Interphase Chromosome ◽  
Hypertonic Medium ◽  
Ovary Cells ◽  
Chromosome Breaks

Induction by H 2 O 2 of DNA and Interphase Chromosome Damage in Plateau-Phase Chinese Hamster Ovary Cells

1992 ◽  
Vol 131 (2) ◽  
pp. 192 ◽  
Author(s):  
George E. Iliakis ◽  
Gabriel E. Pantelias ◽  
Ryuichi Okayasu ◽  
William F. Blakely
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Chromosome Damage ◽  
Plateau Phase ◽  
Interphase Chromosome ◽  
Ovary Cells

DNA and Chromosome Breaks Induced by Iodine- 123-Labeled Estrogen in Chinese Hamster Ovary Cells

1996 ◽  
Vol 146 (2) ◽  
pp. 151 ◽  
Author(s):  
Jeffrey L. Schwartz ◽  
Reba Mustafi ◽  
Alun Hughes ◽  
Eugene R. DeSombre
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Chromosome Breaks ◽  
Iodine 123

Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽  
1993 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
Wanda B. Mackinnon ◽  
Marlen Dyne ◽  
Rebecca Hancock ◽  
Carolyn E. Mountford ◽  
Adrienne J. Grant ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Drug Resistant ◽  
Wild Type ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

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