Response of Human Squamous Cell Carcinoma Xenografts of Different Sizes to Irradiation: Relationship of Clonogenic Cells, Cellular Radiation Sensitivity in Vivo, and Tumor Rescuing Units

1990 ◽  
Vol 123 (3) ◽  
pp. 325 ◽  
Author(s):  
Michael Baumann ◽  
Willem DuBois ◽  
Herman D. Suit
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radiation Sensitivity ◽  
Human Squamous Cell Carcinoma ◽  
Relationship Of ◽  
Clonogenic Cells

Prediction of the Radiation Sensitivity of Human Squamous Cell Carcinoma Cells Using DNA Filter Elution

1990 ◽  
Vol 123 (1) ◽  
pp. 1 ◽  
Author(s):  
Jeffery L. Schwartz ◽  
Reba Mustafi ◽  
Michael A. Beckett ◽  
Ralph R. Weichselbaum
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radiation Sensitivity ◽  
Carcinoma Cells ◽  
Human Squamous Cell Carcinoma

scholarly journals Two alternative cell line models for the study of multiorganic metastasis and immunotherapy in Lung Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Karmele Valencia ◽  
Cristina Sainz ◽  
Cristina Bértolo ◽  
Gabriel de Biurrun ◽  
Jackeline Agorreta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Squamous Cell ◽  
Lung Squamous Cell Carcinoma ◽  
Metastatic Potential ◽  
Human Squamous Cell Carcinoma ◽  
Whole Exome

There is a paucity of adequate mouse models and cell lines available to study lung squamous cell carcinoma (LUSC). We have generated and characterized two models of phenotypically different transplantable LUSC cell lines (UN-SCC679 and UN-SCC680) derived from an N-nitroso-tris-chloroethylurea (NTCU) chemically-induced mouse model in A/J mice. Furthermore, we genetically characterized and compared both LUSC cell lines by performing whole exome and RNA sequencing. These experiments revealed similar genetic and transcriptomic patterns that may correspond to the classical LUSC human subtype. In addition, we compared the immune landscape generated by both tumor cells lines in vivo and assessed their response to immune checkpoint inhibition. The differences between the two cell lines are a good model for the remarkable heterogeneity of human squamous cell carcinoma. Study of the metastatic potential of these models revealed that both cell lines represent the human LUSC organotropism to the brain, bones, liver and adrenal glands. In summary, we have generated a very valuable cell line tools for LUSC research that recapitulates the complexity of the human disease.

13-cis Retinoic Acid in Combination with Interferon-α Enhances Radiation Sensitivity of Human Squamous Cell Carcinoma Cells of the Oral Cavity

1999 ◽  
Vol 175 (11) ◽  
pp. 563-568 ◽  
Author(s):  
Marcel Bläse ◽  
Marco-Michael Zaruba ◽  
Lan Santo-Hoeltje ◽  
Michael Bamberg ◽  
Wolfgang Hoffmann ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retinoic Acid ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radiation Sensitivity ◽  
Carcinoma Cells ◽  
Interferon Α ◽  
Human Squamous Cell Carcinoma
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