Radiosensitizing effect of paclitaxel in vivo in a xenotransplanted human squamous cell carcinoma

1995 ◽  
Vol 121 (S1) ◽  
pp. A53-A53 ◽  
Author(s):  
G. H. Hampel ◽  
Ch. Rübe ◽  
N. Willich
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radiosensitizing Effect ◽  
Human Squamous Cell Carcinoma

scholarly journals Two alternative cell line models for the study of multiorganic metastasis and immunotherapy in Lung Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Karmele Valencia ◽  
Cristina Sainz ◽  
Cristina Bértolo ◽  
Gabriel de Biurrun ◽  
Jackeline Agorreta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Squamous Cell ◽  
Lung Squamous Cell Carcinoma ◽  
Metastatic Potential ◽  
Human Squamous Cell Carcinoma ◽  
Whole Exome

There is a paucity of adequate mouse models and cell lines available to study lung squamous cell carcinoma (LUSC). We have generated and characterized two models of phenotypically different transplantable LUSC cell lines (UN-SCC679 and UN-SCC680) derived from an N-nitroso-tris-chloroethylurea (NTCU) chemically-induced mouse model in A/J mice. Furthermore, we genetically characterized and compared both LUSC cell lines by performing whole exome and RNA sequencing. These experiments revealed similar genetic and transcriptomic patterns that may correspond to the classical LUSC human subtype. In addition, we compared the immune landscape generated by both tumor cells lines in vivo and assessed their response to immune checkpoint inhibition. The differences between the two cell lines are a good model for the remarkable heterogeneity of human squamous cell carcinoma. Study of the metastatic potential of these models revealed that both cell lines represent the human LUSC organotropism to the brain, bones, liver and adrenal glands. In summary, we have generated a very valuable cell line tools for LUSC research that recapitulates the complexity of the human disease.

scholarly journals In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 8117-8125 ◽  
Author(s):  
Hongmei Zhu ◽  
Shu Ruan ◽  
Feng Jia ◽  
Jiusheng Chu ◽  
Yong Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Radiosensitizing Effect
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