Dose-Rate Effects for Mammary Tumor Development in Female Sprague-Dawley Rats Exposed to X and γ Radiation

1989 ◽  
Vol 118 (3) ◽  
pp. 545 ◽  
Author(s):  
J. R. Johnson ◽  
N. J. Gragtmans ◽  
D. K. Myers ◽  
A. R. Jones
Keyword(s):  
Dose Rate ◽  
Mammary Tumor ◽  
Tumor Development ◽  
Sprague Dawley ◽  
Γ Radiation ◽  
Dose Rate Effects ◽  
Sprague Dawley Rats ◽  
Rate Effects

scholarly journals Potency of Murraya koenigii Leaves as Anti-Cancer Mammary in 7,12 dimethylbenz(α) anthracene (DMBA) induced-Sprague Dawley Rats

2020 ◽  
Vol 151 ◽  
pp. 01058
Author(s):  
Siti Aisyah ◽  
Ekowati Handharyani ◽  
Nurliani Bermawie ◽  
Agus Setiyono
Keyword(s):  
Mammary Tumor ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Tumor Development ◽  
Collagen Fibers ◽  
Female Rats ◽  
Sprague Dawley ◽  
Murraya Koenigii ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats

The purpose of the research was to study the potency of Murraya koenigii leaves extract to overcome the mammary tumor in Sprague Dawley rat. Thirty-five female rats were divided into seven groups: control (P1), tumor without therapy (P2), methotrexate group (P3), curative groups (P4 and P5) were given extract after the tumor was formed, and preventive groups (P6 and P7) were given extract before the tumor was formed with dose of 300 and 400 mg/kg, respectively. The induction of mammary tumor in rats were carried out using 7,12 dimethylbenz(α) anthracene (DMBA) subcutaneously. Bodyweight and tumor size were measured every week for 4 weeks. At the end of treatment, rats were euthanized and mammary glands were collected for histopathological examination. The result showed tumor size in P2 was significantly higher (p<0.05) than in other groups. On the other hand, tumor size in P4 and P6 were significantly smaller (p<0.05) compared to P5 and P7. Histopathological changes showed PMN cells, 1-3 layers of cuboid epithelial and solid collagen fibers proliferation in P2, while in P3 to P7 showed moderate collagen fibers proliferation. In conclusion, the administration of the extract at a dose of 300 mg/kg can decelerate tumor development in Sprague Dawley rat mammary gland.

Prevention of Mammary Tumor Development through Neuroimmunomodulation in the Spleen and Lymph Nodes of Old Female Sprague-Dawley Rats by L-Deprenyl

2013 ◽  
Vol 20 (3) ◽  
pp. 141-151 ◽  
Author(s):  
Srinivasan ThyagaRajan ◽  
Lily Tran ◽  
Christine A. Molinaro ◽  
Daila S. Gridley ◽  
David L. Felten ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Mammary Tumor ◽  
Tumor Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Spleen And Lymph Nodes

scholarly journals Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yusuke Matsuya ◽  
Stephen J. McMahon ◽  
Kaori Tsutsumi ◽  
Kohei Sasaki ◽  
Go Okuyama ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ionizing Radiation ◽  
Dose Rate ◽  
Cell Cycle Distribution ◽  
Dose Rates ◽  
Dose Rate Effects ◽  
Rate Effects

In vitro photodynamic therapy of human lung cancer: Investigation of dose-rate effects

Lung Cancer ◽  
1990 ◽  
Vol 6 (1-2) ◽  
pp. 63
Author(s):  
W Matthews ◽  
J Cook ◽  
JB Mitchell ◽  
RR Perry ◽  
S Evans ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Dose Rate ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Dose Rate Effects ◽  
Rate Effects

Lung Cancer Incidence After Exposure of Rats to Low Doses of Radon: Influence of Dose Rate

1994 ◽  
Vol 56 (1-4) ◽  
pp. 93-97 ◽  
Author(s):  
J.P. Morlier ◽  
M. Morin ◽  
G. Monchaux ◽  
P. Fritsch ◽  
J.F. Pineau ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Sprague Dawley ◽  
Survival Times ◽  
Radon Exposure ◽  
Sprague Dawley Rats ◽  
Low Levels ◽  
And Control

Abstract To study the effect on lung cancer incidence of a long exposure to low levels of radon, 500 male 3-month-old Sprague-Dawley rats, were exposed to a cumulative dose of 25 WLM of radon and its daughters, 6 hours a day, 5 days a week, during 18 months. Exposure conditions were controlled in order to maintain a defined PAEC: 42 x 10-6 J.m-3 (2 WL), in the range of domestic and environmental exposures. Animals were kept until they died or given euthanasia when moribund. Mean survival times were similar in both irradiated and control groups: 828 days (SD = 169) and 830 days (SD = 137), as well as lung cancer incidence, 0.60% at 25 WLM and 0.63% for controls. The incidence of lung lesions was compared statistically with controls and those previously obtained at cumulative exposures of 25 and 50 WLM delivered over a 4-6 month period, inducing a significant increase of lung cancer, 2.2% and 3.8% respectively. Such a comparison showed a decreased lung cancer incidence related to a decrease in the dose rate for low levels of radon exposure.

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