Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: II. Causes of Death

1978 ◽  
Vol 74 (3) ◽  
pp. 415 ◽  
Author(s):  
J. R. Maisin ◽  
A. Declève ◽  
G. B. Gerber ◽  
G. Mattelin ◽  
M. Lambiet-Collier ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Causes Of Death ◽  
Whole Body ◽  
Long Term Effects ◽  
Chemical Protection

scholarly journals Effect of ionizing radiation on human skeletal muscle precursor cells

2013 ◽  
Vol 47 (4) ◽  
pp. 376-381 ◽  
Author(s):  
Mihaela Jurdana ◽  
Maja Cemazar ◽  
Katarina Pegan ◽  
Tomaz Mars
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Ionizing Radiation ◽  
Human Skeletal Muscle ◽  
Long Term Effects ◽  
Post Irradiation ◽  
Acute Response ◽  
Proliferation Capacity ◽  
Myoblast Proliferation

Abstract Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death. Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70). Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.

scholarly journals Transitional Cell Carcinomas of the Urinary Tract in a Colony of Beagle Dogs

1989 ◽  
Vol 26 (6) ◽  
pp. 455-461 ◽  
Author(s):  
K. J. Nikula ◽  
S. A. Benjamin ◽  
G. M. Angleton ◽  
A. C. Lee
Keyword(s):  
Urinary Tract ◽  
Transitional Cell ◽  
Clinical Signs ◽  
Conclusive Evidence ◽  
Whole Body ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Significant Difference ◽  
Microscopic Features

Gross and light microscopic features of transitional cell carcinomas (TCC) of the urinary tract were examined in Beagle dogs used for the study of the long-term effects of low-dose, whole-body, 60Co gamma radiation. Thirty-eight cases of TCC occurred among 990 dogs that were from 0 to 14 years of age. There was no conclusive evidence of a radiation effect. The 38 TCC were equally divided between male and female dogs, but there was a significant difference in the sex distribution of urethra-origin TCC. Eleven males had a primary urethral TCC compared to only two females. There was no significant difference between the urethra-origin and bladder-origin TCCs in the number of tumors that caused clinical signs, metastasized, or that contributed to the death of the dog. All cases of urethral TCC in male dogs occurred in the prostatic urethra. The majority of these cases were not recognized to be neoplasms at gross necropsy, but microscopic examination revealed the TCC. Our findings differ from previous reports stating that TCC occurs more frequently in female than male dogs, and they especially differ from reports claiming that urethra-origin TCC is predominately a disease of female dogs.

Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

2014 ◽  
Vol 200 (3-4) ◽  
pp. 240-252 ◽  
Author(s):  
Kahori Kinoshita ◽  
Hisako Ishimine ◽  
Kenshiro Shiraishi ◽  
Harunosuke Kato ◽  
Kentaro Doi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Long Term Effects ◽  
Skin Exposure ◽  
Short And Long Term

Long-term effects of ionizing radiation after the Chernobyl accident: Possible contribution of historic dose

2018 ◽  
Vol 165 ◽  
pp. 55-62 ◽  
Author(s):  
Laila Omar-Nazir ◽  
Xiaopei Shi ◽  
Anders Moller ◽  
Timothy Mousseau ◽  
Soohyun Byun ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Chernobyl Accident ◽  
Long Term Effects

scholarly journals Long-Term Effects of Whole-Body Vibration on Human Gait: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 10 ◽  
Author(s):  
Matthieu Fischer ◽  
Thomas Vialleron ◽  
Guillaume Laffaye ◽  
Paul Fourcade ◽  
Tarek Hussein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Human Gait ◽  
Long Term Effects ◽  
Body Vibration
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