Long-term effects of ionizing radiation after the Chernobyl accident: Possible contribution of historic dose

2018 ◽  
Vol 165 ◽  
pp. 55-62 ◽  
Author(s):  
Laila Omar-Nazir ◽  
Xiaopei Shi ◽  
Anders Moller ◽  
Timothy Mousseau ◽  
Soohyun Byun ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Chernobyl Accident ◽  
Long Term Effects

scholarly journals Effect of ionizing radiation on human skeletal muscle precursor cells

2013 ◽  
Vol 47 (4) ◽  
pp. 376-381 ◽  
Author(s):  
Mihaela Jurdana ◽  
Maja Cemazar ◽  
Katarina Pegan ◽  
Tomaz Mars
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Ionizing Radiation ◽  
Human Skeletal Muscle ◽  
Long Term Effects ◽  
Post Irradiation ◽  
Acute Response ◽  
Proliferation Capacity ◽  
Myoblast Proliferation

Abstract Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death. Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70). Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.

Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

2014 ◽  
Vol 200 (3-4) ◽  
pp. 240-252 ◽  
Author(s):  
Kahori Kinoshita ◽  
Hisako Ishimine ◽  
Kenshiro Shiraishi ◽  
Harunosuke Kato ◽  
Kentaro Doi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Long Term Effects ◽  
Skin Exposure ◽  
Short And Long Term

Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: II. Causes of Death

1978 ◽  
Vol 74 (3) ◽  
pp. 415 ◽  
Author(s):  
J. R. Maisin ◽  
A. Declève ◽  
G. B. Gerber ◽  
G. Mattelin ◽  
M. Lambiet-Collier ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Causes Of Death ◽  
Whole Body ◽  
Long Term Effects ◽  
Chemical Protection

Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study

2013 ◽  
Vol 52 (4) ◽  
pp. 451-461 ◽  
Author(s):  
Mayur V. Bakshi ◽  
Zarko Barjaktarovic ◽  
Omid Azimzadeh ◽  
Stefan J. Kempf ◽  
Juliane Merl ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Low Dose ◽  
Neonatal Mouse ◽  
Mouse Heart ◽  
Long Term Effects ◽  
Proteomic Study

scholarly journals A New Model of Short- and Long-term Effects of Exposure to Ionizing Radiation in Hematopoietic System of Human

2008 ◽  
Vol 43 (5) ◽  
Author(s):  
I. Akushevich ◽  
G. Veremeyeva ◽  
S. Ukraintseva ◽  
K. Arbeev ◽  
A. Akleyev ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Long Term Effects ◽  
Hematopoietic System ◽  
New Model ◽  
Short And Long Term

An early treatment with 17-β-estradiol is neuroprotective against the long-term effects of neonatal ionizing radiation exposure

2011 ◽  
Vol 118 (4) ◽  
pp. 626-635 ◽  
Author(s):  
Lucila G. Caceres ◽  
Soledad L. Uran ◽  
María A. Zorrilla Zubilete ◽  
Juan I. Romero ◽  
Francisco Capani ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Early Treatment ◽  
Long Term Effects ◽  
Ionizing Radiation Exposure
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