Modifications of the Inactivation by Ionizing Radiations of the Transforming Activity of DNA in Spores and Dry Cells

1965 ◽  
Vol 24 (1) ◽  
pp. 43 ◽  
Author(s):  
Hiroshi Tanooka ◽  
Franklin Hutchinson
Keyword(s):  
Transforming Activity ◽  
Ionizing Radiations

scholarly journals The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity

1993 ◽  
Vol 268 (16) ◽  
pp. 11548-11552
Author(s):  
A.D. Cox ◽  
S.M. Graham ◽  
P.A. Solski ◽  
J.E. Buss ◽  
C.J. Der
Keyword(s):  
Transforming Activity ◽  
Carboxyl Terminal

scholarly journals The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Brianna J. Klein ◽  
Anagha Deshpande ◽  
Khan L. Cox ◽  
Fan Xuan ◽  
Mohamad Zandian ◽  
...  
Keyword(s):  
Critical Role ◽  
Cellular Transformation ◽  
Acute Leukemias ◽  
Hematopoietic Stem ◽  
Nucleosome Core ◽  
Stem And Progenitor Cells ◽  
Transforming Activity

AbstractChromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10PZP), which is consistently impaired or deleted in leukemogenic AF10 translocations, plays a critical role in blocking malignant transformation. Incorporation of functional AF10PZP into the leukemogenic CALM-AF10 fusion prevents the transforming activity of the fusion in bone marrow-derived hematopoietic stem and progenitor cells in vitro and in vivo and abrogates CALM-AF10-mediated leukemogenesis in vivo. Crystallographic, biochemical and mutagenesis studies reveal that AF10PZP binds to the nucleosome core particle through multivalent contacts with the histone H3 tail and DNA and associates with chromatin in cells, colocalizing with active methylation marks and discriminating against the repressive H3K27me3 mark. AF10PZP promotes nuclear localization of CALM-AF10 and is required for association with chromatin. Our data indicate that the disruption of AF10PZP function in the CALM-AF10 fusion directly leads to transformation, whereas the inclusion of AF10PZP downregulates Hoxa genes and reverses cellular transformation. Our findings highlight the molecular mechanism by which AF10 targets chromatin and suggest a model for the AF10PZP-dependent CALM-AF10-mediated leukemogenesis.

Food irradiation: Effect of ionizing and non-ionizing radiations on preservation of fruits and vegetables– a review

2021 ◽  
Author(s):  
Bhawna Bisht ◽  
Pooja Bhatnagar ◽  
Prateek Gururani ◽  
Vinod Kumar ◽  
Mahipal Singh Tomar ◽  
...  
Keyword(s):  
Fruits And Vegetables ◽  
Food Irradiation ◽  
Irradiation Effect ◽  
Ionizing Radiations

scholarly journals PO-1078 Ionizing radiations sustain Glioblastoma cell dedifferentiation to a stem phenotype through Survivin

2015 ◽  
Vol 115 ◽  
pp. S582
Author(s):  
P. Dahan ◽  
J. Martinez Gala ◽  
C. Delmas ◽  
S. Monferran ◽  
L. Malric ◽  
...  
Keyword(s):  
Glioblastoma Cell ◽  
Cell Dedifferentiation ◽  
Ionizing Radiations

The Prompt Detection of Ionizing Radiations by a Marine Coelenterate

1971 ◽  
Vol 46 (1) ◽  
pp. 52 ◽  
Author(s):  
Donald J. Kimeldorf ◽  
Rosanne W. Fortner
Keyword(s):  
Ionizing Radiations

Biological Hazards of Ionizing Radiations

1959 ◽  
Vol 10 (4) ◽  
pp. 77-83
Author(s):  
J Rotblat
Keyword(s):  
Ionizing Radiations

scholarly journals A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 ◽  
Vol 271 (30) ◽  
pp. 17644-17649 ◽  
Author(s):  
Naoya Asai ◽  
Hideki Murakami ◽  
Toshihide Iwashita ◽  
Masahide Takahashi
Keyword(s):  
Adaptor Proteins ◽  
Transforming Activity
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