Protective Action of Carbon Monoxide in Mammalian Whole-Body X-Irradiation

1955 ◽  
Vol 3 (2) ◽  
pp. 157 ◽  
Author(s):  
Eugene B. Konecci ◽  
William F. Taylor ◽  
Syrrel S. Wilks
Keyword(s):  
Carbon Monoxide ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation

A STUDY OF THE PROTECTIVE ACTION OF SEROTONIN (5-HYDROXYTRYPTAMINE) AGAINST WHOLE-BODY X-IRRADIATION IN MICE WITH THE AID OF CHROMIUM 51

1963 ◽  
Vol 41 (2) ◽  
pp. 347-360 ◽  
Author(s):  
P. V. Vittorio ◽  
E. W. Wight ◽  
B. E. Sinnott
Keyword(s):  
Radiation Effect ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation ◽  
Initial Radiation ◽  
Radioprotective Agent

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

Protective effect of artificially induced ‘hibernation’ against lethal doses of whole body x-irradiation in CF1 male mice

1959 ◽  
Vol 196 (6) ◽  
pp. 1211-1213 ◽  
Author(s):  
Sondra M. Kuskin ◽  
S. C. Wang ◽  
Roberts Rugh
Keyword(s):  
Protective Action ◽  
Lethal Dose ◽  
Lethal Effect ◽  
The Body ◽  
Whole Body ◽  
Protective Mechanism ◽  
Slight Reduction ◽  
Male Mice ◽  
Degree Of Protection ◽  
X Irradiation

Hypothermia induced by the use of neuroplegic drugs such as Hydergine, chlorpromazine or promethazine, followed by refrigeration, does not significantly enhance the protective action afforded by refrigeration alone against the lethal dose of whole body x-irradiation in CF1 male mice. The neuroplegic drugs, without refrigeration, provide a slight degree of protection, probably due to the slight reduction in the body temperature. It appears that the action of hypothermia as a protective mechanism depends not on depression of metabolism alone, but on a general depression of bodily processes. Urethane, in conjunction with refrigeration, appears to augment the lethal effect of x-irradiation in the CF1 strain of male mice.

A STUDY OF THE PROTECTIVE ACTION OF SEROTONIN (5-HYDROXYTRYPTAMINE) AGAINST WHOLE-BODY X-IRRADIATION IN MICE WITH THE AID OF CHROMIUM 51

1963 ◽  
Vol 41 (1) ◽  
pp. 347-360 ◽  
Author(s):  
P. V. Vittorio ◽  
E. W. Wight ◽  
B. E. Sinnott
Keyword(s):  
Radiation Effect ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation ◽  
Initial Radiation ◽  
Radioprotective Agent

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

Pulmonary diffusion in the dog lung

1962 ◽  
Vol 17 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Albert H. Niden ◽  
Charles Mittman ◽  
Benjamin Burrows
Keyword(s):  
Carbon Monoxide ◽  
Pulmonary Artery ◽  
Experimental Animal ◽  
Venous Blood ◽  
Whole Body ◽  
Mixed Venous Blood ◽  
Pulmonary Diffusion ◽  
Perfused Lung ◽  
Pulmonary Arterial ◽  
Mixed Venous

Methods have been presented for assessing pulmonary diffusion by the “equilibration technique” in the experimental intact dog and perfused lung while controlling ventilation with a whole body respirator. No significant change in diffusion of carbon monoxide was noted between open and closed chest anesthetized animals, with duration of anesthesia in the intact dog, or with duration of perfusion of the isolated dog's lung. There was no demonstrable difference in diffusion when arterialized blood was used as the perfusate in place of mixed venous blood in the lung perfusions suggesting that within the range studied the Po2, Pco2, and pH of pulmonary artery blood does not directly affect the diffusion of carbon monoxide. Retrograde perfusions of dogs' lungs did not significantly alter diffusion, suggesting that pulmonary venous resistance was not significantly lower than pulmonary arterial resistance in the perfused dog lung at the flows and pressures studied. The equilibration technique for measuring pulmonary diffusion and assessing the uniformity of diffusion was well suited to the study of pulmonary diffusing characteristics in the experimental animal. Submitted on January 8, 1962

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