Observations on the Metabolism of the Culture Form of Trypanosoma congolense

1959 ◽  
Vol 45 (2) ◽  
pp. 204 ◽  
Author(s):  
Theodor von Brand ◽  
Eleanor Johnson Tobie
Keyword(s):  
Trypanosoma Congolense ◽  
Culture Form

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

2021 ◽  
Vol 49 (02) ◽  
pp. 142-147
Author(s):  
Michael Leschnik ◽  
Katja Silbermayr ◽  
Abigail Guija ◽  
Barbara Nell
Keyword(s):  
Clinical Improvement ◽  
Successful Treatment ◽  
Initial Treatment ◽  
Blood Smear ◽  
Forest Type ◽  
Trypanosoma Congolense ◽  
Lethal Outcome ◽  
Complete Eradication ◽  
Western Africa ◽  
Mongrel Dog

AbstractCanine African Trypanosomosis (CAT) is a rarely described disease with frequently lethal outcome. A 5-year-old female mongrel dog weighing 22 kg was presented in Austria due to unilateral uveitis, pancytopenia, and anorexia 4 months after return from a trip through Western Africa. Trypanosoma spp. flagellates were detected in a blood smear and identified as Trypanosoma congolense forest type by PCR. Initial treatment with imidocarb and miltefosine led to clinical improvement but only isometamidium chloride hydrochloride applied intramuscularly led to complete eradication of the pathogen from the dog’s blood 4 months later.

scholarly journals The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities

2014 ◽  
Vol 203 (3-4) ◽  
pp. 270-275 ◽  
Author(s):  
Annelise Sahin ◽  
Corinne Asencio ◽  
Julien Izotte ◽  
Davita Pillay ◽  
Virginie Coustou ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Congolense

Ethidium bromide: pharmacokinetics and efficacy against trypanosme infections in rabbits and calves

Parasitology ◽  
1982 ◽  
Vol 85 (1) ◽  
pp. 127-148 ◽  
Author(s):  
R. J. Gilbert ◽  
B. A. Newton
Keyword(s):  
Drug Treatment ◽  
Trypanosoma Brucei ◽  
Ethidium Bromide ◽  
Intramuscular Injection ◽  
Trypanosoma Congolense ◽  
Tissue Fluid ◽  
Infected Calf ◽  
Patent Period ◽  
Drug Levels ◽  
Fluid Levels

SUMMARY[14C[ethidium bromide has been used to determine drug levels in tissues and body fluids of rabbits and calves following intramuscular injection. Uninfected and Trypanosoma brucei- or Trypanosoma congolense-infected animals were studied. Blood and tissue fluid levels reached a maximum within 1 h and then fell rapidly; after 96 h 80–90% of the radioactivity injected had been excreted, approximately one third in urine and two thirds in faeces. By 1 h after injection of 1 mg [14C]ethidium/kg into a T. congolense-infected calf, 70–80% of the radioactivity in blood was found to be bound to trypanosomes. Doses of 1 or 10 mg/kg were found not to be curative for T. congolense or T. brucei infections in rabbits; drug treatment resulted in a period of sub-patent parasitaemia which was always followed by a relapse. Examination of the prophylactic action of ethidium in rabbits showed that the drug extended the pre-patent period following trypanosome inoculation but provided no absolute protection. A period of ‘apparent’ prophylaxis observed after drug treatment of infected rabbits has been correlated with the presence of anti-trypanosome IgG in the serum.

Bovine trypanosomosis in Gimbi district of Western Oromia, Ethiopia

2010 ◽  
Vol 60 (2) ◽  
pp. 123-131 ◽  
Author(s):  
Ashenafi Hagos ◽  
Hailu Yacob ◽  
Asoke Basu ◽  
Degneh Efrem
Keyword(s):  
Sea Level ◽  
Rainy Season ◽  
Age Groups ◽  
Trypanosoma Congolense ◽  
Dry Season ◽  
Major Health Problem ◽  
Major Health ◽  
Glossina Morsitans Submorsitans ◽  
Bovine Trypanosomosis ◽  
Significant Difference

AbstractA study on the epidemiology of bovine trypanosomosis was conducted from September 2006 to April 2007 in six villages of the Gimbi district in west Wollega zone of Ethiopia. The prevalence of the disease, the apparent densities and distribution of tsetse and other biting flies in two seasons, the dry and rainy, were determined. The results of a questionnaire survey from 80 farmers revealed that trypanosomosis was a major health problem affecting animals and impeding agricultural activities.A total of 568 blood samples were collected from randomly selected animals (280 animals in rainy and 288 in dry season) and revealed the presence of Trypanosoma congolense Broden, 1904 and T. vivax Zieman, 1905 in the area. Trypanosoma congolense was the dominant species that accounted for 66.2% of the infections. The mean packed cell volume (PCV) concentrations were 22.77% (95% CI =19.99-21.55) in parasitaemic and 25.25% (95% CI=24.88-25.61) in aparasitaemic animals with a significant difference (P<0.005). There was a significant (P<0.012) difference in trypanosome infection between age groups of cattle, being higher in adults. The overall prevalence of trypanosomosis was 12.5%, while the disease prevalence was higher during the rainy season (15 %) than the dry season (10.1%). In three villages of lowland areas (below 1600 meter above sea level), a higher prevalence was recorded 20.9% and 7.9% as compared to three villages of midland areas (≥ 1600 meter above sea level) 11.8% and 8.3% in late rainy and dry season, respectively.A fly-survey was conducted by using 80 monoconical pyramidal traps and revealed that two tsetse species, namely Glossina morsitans submorsitans Newstead and Glossina tachinoides Westwood were found along with other biting flies (Tabanus, Haematopota and Stomoxys species). Higher numerical catches of Glossina were recorded in late rainy season and the apparent density was positively correlated (r=0.5171) with the prevalence of infection.

scholarly journals Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to Trypanosoma congolense Infection

2009 ◽  
Vol 77 (9) ◽  
pp. 3948-3957 ◽  
Author(s):  
Birgit Rathkolb ◽  
Harry A. Noyes ◽  
Andy Brass ◽  
Paul Dark ◽  
Helmut Fuchs ◽  
...  
Keyword(s):  
Survival Time ◽  
Clinical Chemistry ◽  
Inbred Mice ◽  
Protozoan Parasite ◽  
Physiological Effect ◽  
Trypanosoma Congolense ◽  
Survival Times ◽  
Inflammatory Reactions ◽  
Congenic Mice ◽  
Trait Loci

ABSTRACT Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background were developed for each of these loci. The congenic mice were used to physically map the regions containing the QTL gene(s) and to investigate the physiological effect of each locus. Clinical chemistry data for infected A/J, C57BL/6, and BALB/c mice were obtained for 15 analytes at five time points. Congenic mice were assessed for survival, parasitemia, and anemia as well as seven clinical-chemical analytes. The survival times were significantly increased in the Tir1 and Tir2 mice but not Tir3 congenic mice. The survival time of the parental inbred mice correlated negatively with parasitemia but positively with alanine aminotransferase activities in serum, suggesting that inflammatory reactions in the liver had a beneficial effect possibly associated with reduced parasitemia. However, there was no difference in parasitemia or liver enzyme activities of Tir1 and Tir2 congenic mice relative to their controls, showing that survival, parasitemia, and degree of liver damage are not associated with each other, despite the correlation in the parental lines. These data suggest that the congenic loci affect survival but do not affect control of parasite number. They may therefore act by limiting the pathological consequences of T. congolense infection.

Trypanosome infections and survival in tsetse

Parasitology ◽  
1998 ◽  
Vol 116 (S1) ◽  
pp. S23-S28 ◽  
Author(s):  
I. Maudlin ◽  
S. C. Welburn ◽  
P. J. M. Milligan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Trypanosoma Brucei ◽  
Glossina Morsitans Morsitans ◽  
Trypanosoma Congolense ◽  
Vectorial Capacity ◽  
Trypanosome Infection ◽  
Trypanosoma Brucei Rhodesiense ◽  
Glossina Morsitans ◽  
Differential Effects

SummaryThe effect of trypanosome infection on vector survival was observed in a line of Glossina morsitans morsitans selected for susceptibility to trypanosome infection. The differential effects of midgut and salivary gland infections on survival were examined by exposing flies to infection with either Trypanosoma congolense which colonizes midgut and mouthparts or Trypanosoma brucei rhodesiense which colonizes midgut and salivary glands. A comparison of the survival distributions of uninfected flies with those exposed to infection showed that salivary gland infection significantly reduces tsetse survival; midgut infection had little or no effect on the survival of tsetse. The significance of these findings is discussed in relation to the vectorial capacity of wild flies.

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