Differential mRNA Display Cloning and Characterization of a Cryptosporidium parvum Gene Expressed during Intracellular Development

1999 ◽  
Vol 85 (2) ◽  
pp. 213 ◽  
Author(s):  
Alison A. Schroeder ◽  
Catherine E. Lawrence ◽  
Mitchell S. Abrahamsen
Keyword(s):  
Cryptosporidium Parvum ◽  
Mrna Display ◽  
Differential Mrna Display

Molecular cloning and characterization of a Cryptosporidium parvum elongation factor-2 gene

1995 ◽  
Vol 71 (1) ◽  
pp. 143-147 ◽  
Author(s):  
Douglas E. Jones ◽  
Tu D. Tu ◽  
Sameer Mathur ◽  
Raymond W. Sweeney ◽  
Douglas P. Clark
Keyword(s):  
Molecular Cloning ◽  
Cryptosporidium Parvum ◽  
Elongation Factor ◽  
Elongation Factor 2

Molecular characterization of Danish Cryptosporidium parvum isolates

Parasitology ◽  
2002 ◽  
Vol 125 (04) ◽  
Author(s):  
H. L. ENEMARK ◽  
P. AHRENS ◽  
C. D. JUEL ◽  
E. PETERSEN ◽  
R. F. PETERSEN ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Cryptosporidium Parvum

scholarly journals Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model

2012 ◽  
Vol 78 (6) ◽  
pp. 1746-1751 ◽  
Author(s):  
Gabriela Certad ◽  
Sadia Benamrouz ◽  
Karine Guyot ◽  
Anthony Mouray ◽  
Thierry Chassat ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cryptosporidium Parvum ◽  
Severe Infection ◽  
Digestive Cancer ◽  
Content Type ◽  
Near Drowning ◽  
Neoplastic Process ◽  
First Time

ABSTRACTIn the present work, we report the characterization of aCryptosporidium parvumstrain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone allogeneic stem cell transplantation. After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified asC. parvumII2A15G2R1 (subtype linked to zoonotic exposure) and inoculated into SCID mice. In this host, this virulentC. parvumisolate induced not only severe infection but also invasive gastrointestinal and biliary adenocarcinoma. The observation of adenocarcinomas that progressed through all layers of the digestive tract to the subserosa and spread via blood vessels confirmed the invasive nature of the neoplastic process. These results indicate for the first time that a human-derivedC. parvumisolate is able to induce digestive cancer. This study is of special interest considering the exposure of a large number of humans and animals to this waterborne protozoan, which is highly tumorigenic when inoculated in a rodent model.

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