Passive Transfer of Protective Immunity to Larval Dirofilaria immitis from Dogs to BALB/C Mice

1991 ◽  
Vol 77 (2) ◽  
pp. 254 ◽  
Author(s):  
David Abraham ◽  
Robert B. Grieve
Keyword(s):  
Protective Immunity ◽  
Dirofilaria Immitis ◽  
Passive Transfer

Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections

1988 ◽  
Vol 39 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Robert B. Grieve ◽  
Barbara P. Seibert ◽  
David Abraham ◽  
Marcia Mika-Grieve
Keyword(s):  
Protective Immunity ◽  
Dirofilaria Immitis

A mosquito AgTRIO monoclonal antibody reduces early Plasmodium infection of mice

2021 ◽  
Author(s):  
Yu-Min Chuang ◽  
Xu-Dong Tang ◽  
Erol Fikrig
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Protective Immunity ◽  
Passive Immunization ◽  
Passive Transfer ◽  
Infected Mosquito ◽  
Carboxyl Terminus ◽  
Plasmodium Infection ◽  
Significant Protection ◽  
Malaria Vaccines

Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites into the skin of a vertebrate host. Passive immunization of mice with mosquito AgTRIO antisera offers significant protection against Plasmodium infection of mice. Furthermore, passive transfer of both AgTRIO antisera and an anti-circumsporozoite protein monoclonal antibody provides synergistic protection. In this study, we generated monoclonal antibodies against AgTRIO to delineate the regions of AgTRIO associated with protective immunity. Monoclonal antibody 13F-1 markedly reduced Plasmodium infection in mice and recognized a region, VDDLMAKFN, in the carboxyl terminus of AgTRIO. 13F-1 is an IgG2a isotype monoclonal antibody and the Fc region is required for protection. These data will aid in the generation of future malaria vaccines that may include both pathogen and vector antigens.

Nematospiroides dubius: Passive transfer of protective immunity to mice with monoclonal antibodies

1988 ◽  
Vol 66 (1) ◽  
pp. 7-12 ◽  
Author(s):  
I.J. East ◽  
E.A. Washington ◽  
P.J. Brindley ◽  
G.F. Monroy ◽  
N. Scott-Young
Keyword(s):  
Monoclonal Antibodies ◽  
Protective Immunity ◽  
Passive Transfer ◽  
Nematospiroides Dubius

scholarly journals Evaluation of protective immunity against experimental Dirofilaria immitis infection in Beagle dogs

1970 ◽  
pp. 93-98
Author(s):  
MH Talukder ◽  
K Ueda ◽  
T Hajime ◽  
S Kanako ◽  
S Kawamura ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Dirofilaria Immitis ◽  
Pulmonary Arteries ◽  
Challenge Infection ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Third Stage ◽  
Gamma Irradiated ◽  
The Right ◽  
And Control

Prevention of heartworm is a key goal of pet wellness. An experimental trial was carried out to induce the immunologic protection against Dirofilaria immitis infection in dogs during the period from July 2005 to November 2006.  To evaluate the three protocols of immunization, dogs were separately immunized with gamma-irradiated infective larvae; with chemical abbreviation of infection; with chemical abbreviation plus Freund's complete adjuvant respectively. Each trial consisted of immunized and control groups and each group composed of two dogs. All dogs used for this study were subcutaneously challenged with 100 intact third-stage larvae at designated times after the last immunization following the above three protocols. The dogs were euthanized and necropsized between 120 to 175 days after challenge infection for the worms in the right ventricle of the heart and pulmonary arteries. Number of worms and sexes were determined. A mean of 36 worms from the immunized groups with irradiated L3; 33 worms from the chemically-abbreviated group whereas 13 worms from the chemical abbreviation plus Freund's complete adjuvant group were recovered. The percentages of the average protection in three groups were 45.80%, 55.05% and 77.90% respectively. The adjuvant enhanced the protective immunity against L3 challenge infection. The ELISA values do not explain the intensity of the protection, but shown adequately the immunized dogs responding to the immunization performed in this experiment. Key words: Heartworm, protective immunity, chemical-abbreviation, gamma-irradiated larvae DOI = 10.3329/bjvm.v5i1.1323 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 93-98

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