Protective Immunity against Tetrathyridia of Mesocestoides corti by Passive Transfer of Serum in Mice

1972 ◽  
Vol 58 (2) ◽  
pp. 244 ◽  
Author(s):  
John C. Kowalski ◽  
Ralph E. Thorson
Keyword(s):  
Protective Immunity ◽  
Passive Transfer

A mosquito AgTRIO monoclonal antibody reduces early Plasmodium infection of mice

2021 ◽  
Author(s):  
Yu-Min Chuang ◽  
Xu-Dong Tang ◽  
Erol Fikrig
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Protective Immunity ◽  
Passive Immunization ◽  
Passive Transfer ◽  
Infected Mosquito ◽  
Carboxyl Terminus ◽  
Plasmodium Infection ◽  
Significant Protection ◽  
Malaria Vaccines

Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites into the skin of a vertebrate host. Passive immunization of mice with mosquito AgTRIO antisera offers significant protection against Plasmodium infection of mice. Furthermore, passive transfer of both AgTRIO antisera and an anti-circumsporozoite protein monoclonal antibody provides synergistic protection. In this study, we generated monoclonal antibodies against AgTRIO to delineate the regions of AgTRIO associated with protective immunity. Monoclonal antibody 13F-1 markedly reduced Plasmodium infection in mice and recognized a region, VDDLMAKFN, in the carboxyl terminus of AgTRIO. 13F-1 is an IgG2a isotype monoclonal antibody and the Fc region is required for protection. These data will aid in the generation of future malaria vaccines that may include both pathogen and vector antigens.

Nematospiroides dubius: Passive transfer of protective immunity to mice with monoclonal antibodies

1988 ◽  
Vol 66 (1) ◽  
pp. 7-12 ◽  
Author(s):  
I.J. East ◽  
E.A. Washington ◽  
P.J. Brindley ◽  
G.F. Monroy ◽  
N. Scott-Young
Keyword(s):  
Monoclonal Antibodies ◽  
Protective Immunity ◽  
Passive Transfer ◽  
Nematospiroides Dubius

scholarly journals Intranasal Immunization with Toxoplasma gondii SAG1 Induces Protective Cells into Both NALT and GALT Compartments

2000 ◽  
Vol 68 (2) ◽  
pp. 969-972 ◽  
Author(s):  
F. Velge-Roussel ◽  
P. Marcelo ◽  
A. C. Lepage ◽  
D. Buzoni-Gatel ◽  
D. T. Bout
Keyword(s):  
Lymph Node ◽  
Toxoplasma Gondii ◽  
Mesenteric Lymph Node ◽  
Lymphoid Tissue ◽  
Protective Immunity ◽  
Cellular Response ◽  
Passive Transfer ◽  
Cellular Activation ◽  
Mesenteric Lymph ◽  
Brain Cysts

ABSTRACT Intranasal (i.n.) immunization with the SAG1 protein ofToxoplasma gondii plus cholera toxin (CT) provides protective immunity. The aim of this study was to analyze the cellular activation of several mucosal compartments after i.n. immunization. Cervical and mesenteric lymph node (CLN and MLN, respectively) lymphoid cell and intraepithelial lymphocyte (IEL) passive transfer experiments were performed with CBA/J mice immunized i.n. with SAG1 plus CT. CLN and MLN cells and IEL isolated 42 days after immunization conferred protective immunity on naive recipient mice challenged with strain 76KT. gondii, as assessed by the reduction in the number of brain cysts. There were proliferative specific responses in nose-associated lymphoid tissue and the CLN and MLN cells from mice immunized with SAG1 plus CT, but no cytokine was detectable. Thus, protective immunity is associated with a specific cellular response in the nasal and mesenteric compartments after i.n. immunization.

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