Treatment of Hickman Catheter Sepsis Using Antibiotic Lock Technique

1995 ◽  
Vol 16 (10) ◽  
pp. 596-598 ◽  
Author(s):  
Elizabeth A. Krzywda ◽  
Deborah A. Andris ◽  
Charles E. Edmiston ◽  
Edward J. Quebbeman
Keyword(s):  
Hickman Catheter ◽  
Catheter Sepsis ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

Treatment of Hickman Catheter Sepsis Using Antibiotic Lock Technique

1995 ◽  
Vol 16 (10) ◽  
pp. 596-598 ◽  
Author(s):  
Elizabeth A. Krzywda ◽  
Deborah A. Andris ◽  
Charles E. Edmiston ◽  
Edward J. Quebbeman
Keyword(s):  
Hickman Catheter ◽  
Catheter Sepsis ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

Hickman Catheter Sepsis Caused by Yersinia enterocolitica

1990 ◽  
Vol 83 (6) ◽  
pp. 724-725 ◽  
Author(s):  
Dennis B. Cornfield ◽  
Israel H. Lichtenstein
Keyword(s):  
Yersinia Enterocolitica ◽  
Hickman Catheter ◽  
Catheter Sepsis

scholarly journals Controversies on Antibiotic Lock Technique Duration Experience with a 3-Day Course for Hematological Patients

2011 ◽  
Vol 32 (4) ◽  
pp. 408-410 ◽  
Author(s):  
Andrea Tendas ◽  
Pasquale Niscola ◽  
Luca Cupelli ◽  
Alessandra Spagnoli ◽  
Laura Scaramucci ◽  
...  
Keyword(s):  
Hematological Patients ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique ◽  
Duration Experience

Failure of antibiotic-lock technique using daptomycin for subcutaneous injection ports in a patient on home parenteral nutrition

2010 ◽  
Vol 60 (6) ◽  
pp. 505-507 ◽  
Author(s):  
Thomas Guimard ◽  
Matthieu Revest ◽  
Cédric Arvieux ◽  
Christian Michelet ◽  
Pierre Tattevin ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Subcutaneous Injection ◽  
Home Parenteral Nutrition ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

scholarly journals Comparative Efficacies of Quinupristin-Dalfopristin, Linezolid, Vancomycin, and Ciprofloxacin in Treatment, Using the Antibiotic-Lock Technique, of Experimental Catheter-Related Infection Due to Staphylococcus aureus

2005 ◽  
Vol 49 (10) ◽  
pp. 4042-4045 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Fiorenza Orlando ◽  
Federico Mocchegiani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Venous Catheter ◽  
Blood Cultures ◽  
Adherent Cell ◽  
Minimal Bactericidal Concentration ◽  
Biofilm Model ◽  
Isotonic Sodium Chloride ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

ABSTRACT We performed in vitro studies to elucidate the bactericidal activity of the antibiotics in an adherent-cell biofilm model. Efficacy studies were performed in a staphylococcal central venous catheter (CVC) infection rat model. Silastic catheters were implanted into the superior cava. Via the CVC the rats were challenged with 1.0 × 106 CFU of a live Staphylococcus aureus strain. Twenty-four hours later, the antibiotic-lock technique was started. All animals were randomized to receive daily isotonic sodium chloride solution, quinupristin-dalfopristin (Q/D), linezolid, vancomycin, or ciprofloxacin at the minimal bactericidal concentration (MBC) and at 1,024 μg/ml in a volume of 0.1 ml that filled the CVC. The main outcome measures were MICs and MBCs for both planktonic and adherent cells, quantitative culture of the catheters and surrounding venous tissues, and quantitative peripheral blood cultures. The killing activities of all antibiotics against the adherent bacteria were at least fourfold lower than those against freely growing cells, with the exception of Q/D, which showed comparable activities against both adherent and planktonic organisms. Overall, Q/D at 1,024 μg/ml produced the greatest reduction in the number of cells recovered from the catheters, while at the same concentration, Q/D and vancomycin demonstrated higher activities than ciprofloxacin or linezolid in reducing the number of organisms recovered from the blood cultures. This study points out that treatment outcome of device-related infections cannot be predicted by the results of a standard susceptibility test such as the MIC. Our findings suggest that the clinically used antibiotics cannot eradicate the CVC infection through the antibiotic-lock technique, even at a concentration of 1,024 μg/ml.

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