scholarly journals Controversies on Antibiotic Lock Technique Duration Experience with a 3-Day Course for Hematological Patients

2011 ◽  
Vol 32 (4) ◽  
pp. 408-410 ◽  
Author(s):  
Andrea Tendas ◽  
Pasquale Niscola ◽  
Luca Cupelli ◽  
Alessandra Spagnoli ◽  
Laura Scaramucci ◽  
...  
Keyword(s):  
Hematological Patients ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique ◽  
Duration Experience

Treatment of Hickman Catheter Sepsis Using Antibiotic Lock Technique

1995 ◽  
Vol 16 (10) ◽  
pp. 596-598 ◽  
Author(s):  
Elizabeth A. Krzywda ◽  
Deborah A. Andris ◽  
Charles E. Edmiston ◽  
Edward J. Quebbeman
Keyword(s):  
Hickman Catheter ◽  
Catheter Sepsis ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

Failure of antibiotic-lock technique using daptomycin for subcutaneous injection ports in a patient on home parenteral nutrition

2010 ◽  
Vol 60 (6) ◽  
pp. 505-507 ◽  
Author(s):  
Thomas Guimard ◽  
Matthieu Revest ◽  
Cédric Arvieux ◽  
Christian Michelet ◽  
Pierre Tattevin ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Subcutaneous Injection ◽  
Home Parenteral Nutrition ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

scholarly journals Comparative Efficacies of Quinupristin-Dalfopristin, Linezolid, Vancomycin, and Ciprofloxacin in Treatment, Using the Antibiotic-Lock Technique, of Experimental Catheter-Related Infection Due to Staphylococcus aureus

2005 ◽  
Vol 49 (10) ◽  
pp. 4042-4045 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Fiorenza Orlando ◽  
Federico Mocchegiani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Venous Catheter ◽  
Blood Cultures ◽  
Adherent Cell ◽  
Minimal Bactericidal Concentration ◽  
Biofilm Model ◽  
Isotonic Sodium Chloride ◽  
Antibiotic Lock ◽  
Antibiotic Lock Technique

ABSTRACT We performed in vitro studies to elucidate the bactericidal activity of the antibiotics in an adherent-cell biofilm model. Efficacy studies were performed in a staphylococcal central venous catheter (CVC) infection rat model. Silastic catheters were implanted into the superior cava. Via the CVC the rats were challenged with 1.0 × 106 CFU of a live Staphylococcus aureus strain. Twenty-four hours later, the antibiotic-lock technique was started. All animals were randomized to receive daily isotonic sodium chloride solution, quinupristin-dalfopristin (Q/D), linezolid, vancomycin, or ciprofloxacin at the minimal bactericidal concentration (MBC) and at 1,024 μg/ml in a volume of 0.1 ml that filled the CVC. The main outcome measures were MICs and MBCs for both planktonic and adherent cells, quantitative culture of the catheters and surrounding venous tissues, and quantitative peripheral blood cultures. The killing activities of all antibiotics against the adherent bacteria were at least fourfold lower than those against freely growing cells, with the exception of Q/D, which showed comparable activities against both adherent and planktonic organisms. Overall, Q/D at 1,024 μg/ml produced the greatest reduction in the number of cells recovered from the catheters, while at the same concentration, Q/D and vancomycin demonstrated higher activities than ciprofloxacin or linezolid in reducing the number of organisms recovered from the blood cultures. This study points out that treatment outcome of device-related infections cannot be predicted by the results of a standard susceptibility test such as the MIC. Our findings suggest that the clinically used antibiotics cannot eradicate the CVC infection through the antibiotic-lock technique, even at a concentration of 1,024 μg/ml.

Antibiotic Lock Technique: A Review of the Literature

2005 ◽  
Vol 39 (2) ◽  
pp. 311-318 ◽  
Author(s):  
Marisel Segarra-Newnham ◽  
Ellen M Martin-Cooper
Keyword(s):  
Data Extraction ◽  
Success Rates ◽  
Coagulase Negative Staphylococci ◽  
Systemic Complications ◽  
Study Selection ◽  
Gram Negative Bacteremia ◽  
Antibiotic Lock ◽  
Therapy Success ◽  
Antibiotic Lock Technique

OBJECTIVE: To review the literature on the use of the antibiotic lock technique (ALT) as a treatment option for patients with highly needed catheters. DATA SOURCES: MEDLINE and International Pharmaceutical Abstracts were searched (1980–August 2004). Search terms included antibiotic lock, catheter infection, and topical treatment. STUDY SELECTION AND DATA EXTRACTION: Articles describing use of ALT in the treatment of catheter infections in humans and studies evaluating in vitro stability of antibiotics were included. DATA SYNTHESIS: ALT has been used in patients with highly needed catheters, usually for parenteral nutrition, cancer chemotherapy, or dialysis. Catheters are considered highly needed when removal is not feasible or desirable due to lack of alternative injection sites for required therapy. Success rates in saving the infected catheter have been variable and may depend on the infecting organism. In addition, there are conflicting data in terms of compatibility of antibiotics with heparin solutions. CONCLUSIONS: Consensus appears to be that the ALT can be tried for patients with highly needed catheters when infection with coagulase-negative staphylococci is documented and no systemic signs of sepsis, such as hypotension, are evident. Most of these patients are likely to need systemic therapy as well. Infection of the catheter associated with systemic gram-negative bacteremia or fungemia will most likely require removal of the catheter to prevent systemic complications. Additional research with the ALT is warranted given unanswered questions.

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