Antibody Response and Local Reactions to Adjuvanted Avian Polyomavirus Vaccines in Psittacine Birds

1994 ◽  
Vol 8 (1) ◽  
pp. 21 ◽  
Author(s):  
Branson W. Ritchie ◽  
Frank D. Niagro ◽  
Kenneth S. Latimer ◽  
Nancy Pritchard ◽  
Cheryl Greenacre ◽  
...  
Keyword(s):  
Antibody Response ◽  
Local Reactions ◽  
Avian Polyomavirus

Viremia, virus shedding, and antibody response during natural avian polyomavirus infection in parrots

2000 ◽  
Vol 217 (1) ◽  
pp. 32-36 ◽  
Author(s):  
David N. Phalen ◽  
C. Steven Radabaugh ◽  
Robert D. Dahlhausen ◽  
Darrel K. Styles
Keyword(s):  
Antibody Response ◽  
Virus Shedding ◽  
Avian Polyomavirus

scholarly journals Phase I Malaria Vaccine Trial with a Long Synthetic Peptide Derived from the Merozoite Surface Protein 3 Antigen

2005 ◽  
Vol 73 (12) ◽  
pp. 8017-8026 ◽  
Author(s):  
Régine Audran ◽  
Michel Cachat ◽  
Floriana Lurati ◽  
Soe Soe ◽  
Odile Leroy ◽  
...  
Keyword(s):  
Antibody Response ◽  
Phase I ◽  
Synthetic Peptide ◽  
Vaccine Trial ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Biologically Active ◽  
Serious Adverse Events ◽  
Local Reactions ◽  
Conserved Region

ABSTRACT The C-terminal conserved region of Plasmodium falciparum merozoite surface protein 3 (MSP3) is the trigger antigen of a protective immune response mediated by cytophilic antibodies. In an open, randomized, two-adjuvant (Montanide ISA 720, aluminum hydroxide) phase I clinical trial we evaluated the safety and immunogenicity of increasing doses of a long synthetic peptide construct spanning the conserved region of MSP3 targeted by biologically active antibodies (MSP3-LSP). Thirty-five healthy volunteers were randomized to receive three subcutaneous injections on days 0, 30, and 120. Of the 100 injections given, 10 caused severe local reactions, 62 caused transient mild to moderate local reactions, and 28 caused no reaction. On the basis of preestablished exclusion criteria, use of the Montanide formulation led to withdrawal of five volunteers after the second injection. This led to a reduction in the subsequent vaccine doses in four of the groups. No vaccine-related serious adverse events occurred throughout the trial. After the third injection, volunteers displayed a marked specific anti-MSP3-LSP antibody response (23/30 individuals, compared with 29/34 individuals for plasma from an area where malaria is endemic), an anti-native MSP3 antibody response (19/30 individuals), a T-cell-antigen-specific proliferative response (26/30 individuals), and gamma interferon production (25/30 individuals). In conclusion, the MSP3-LSP vaccine was immunogenic with both adjuvants, although it was unacceptably reactogenic when it was combined with Montanide. The potential usefulness of the candidate vaccine is supported by the induction of a strong cytophilic response (i.e., the type of anti-MSP3 antibodies involved in antibody-dependent, monocyte-mediated protective mechanisms in areas where malaria is endemic).

Zostavax Elicits Antibody Response in Younger Group

2007 ◽  
Vol 37 (11) ◽  
pp. 24
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Antibody Response
Sign in / Sign up

Export Citation Format

Share Document