Roles and Role Change in Monkey Society: The Consort Relationship of Rhesus Monkeys

Man ◽  
1970 ◽  
Vol 5 (3) ◽  
pp. 449 ◽  
Author(s):  
Vernon Reynolds
Keyword(s):  
Rhesus Monkeys ◽  
Role Change ◽  
Relationship Of

Relationship of carotid pressure and end point during acceleration

1960 ◽  
Vol 15 (5) ◽  
pp. 903-906
Author(s):  
George H. Kydd ◽  
Richard L. Fenichel ◽  
Richard J. Crosbie
Keyword(s):  
Blood Pressure ◽  
Pressure Drop ◽  
Rhesus Monkeys ◽  
Pressure Curve ◽  
Positive Wave ◽  
End Point ◽  
Positive Acceleration ◽  
Tangential Acceleration ◽  
Relationship Of ◽  
Constant Interval

Simultaneous observations have been made of the occurrence of an end point of unconsciousness and carotid blood pressure in rhesus monkeys during positive acceleration. The data indicate that the carotid pressure is influenced initially by a maneuver which gives rise to a positive wave of pressure that is well coordinated with the onset of tangential acceleration, while positive acceleration is at a very low level. Following this, there is a pressure drop that can be described by a time constant, that is, a function of peak g. The data indicate that the end point occurs after a constant interval following the pressure minimum and is therefore related to the slope of the blood pressure curve. The significance of this observation with respect to blood supply is discussed. Submitted on March 14, 1960

PLASMA LEVELS OF UNCONJUGATED STEROIDS IN MALE BABOONS (PAPIO HAMADRYAS) AND RHESUS MONKEYS (MACACA MULATTA)

1976 ◽  
Vol 82 (3) ◽  
pp. 644-651 ◽  
Author(s):  
T. Aso ◽  
N. Goncharov ◽  
Z. Cekan ◽  
E. Diczfalusy
Keyword(s):  
Plasma Levels ◽  
Rhesus Monkeys ◽  
Species Difference ◽  
Testicular Tissue ◽  
Papio Hamadryas ◽  
Endocrine Function ◽  
Suitable Animal Model ◽  
17 Hydroxyprogesterone ◽  
Relationship Of ◽  
Reproductive Processes

ABSTRACT In an attempt to find suitable animal models to aid in the study of the reproductive processes of the human male, plasma levels of unconjugated pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 20α-dihydroprogesterone, 17-hydroxyprogesterone, androstenedione, testosterone, dihydrotestosterone, oestrone and oestradiol were measured in 18 male baboons and 10 male rhesus monkeys and the steroid levels were compared with those previously established in normospermic, middle-aged men. Significant species differences were found with regard to the three Δ5-steroids studied; whereas the approximate relationship of pregnenolone to 17-hydroxypregnenolone and dehydroepiandrosterone was 1:2:4 in men, the corresponding relationship was 1:5:30 in rhesus monkeys and 1:10:10 in baboons. Similar levels of 20α-dihydroprogesterone were found in the three species. On the other hand, the 17-hydroxyprogesterone levels in baboons were much lower and the levels of androstenedione lower than those found in men and in rhesus monkeys. No species difference was found with regard to circulating testosterone levels. However, both rhesus monkeys and baboons exhibited much higher levels of dihydrostestosterone than did men. Oestrone levels were higher in baboons than in men and oestradiol levels were higher in rhesus monkeys than in men and in baboons. The significant differences in circulating steroid levels suggest that further studies (including i.a. steroid analyses in testicular tissue, seminal plasma and spermatic artery and vein following both stimulation and suppression of testicular endocrine function) are required before preference can be given to any of the two species studied as a suitable animal model for the study of new fertility regulating agents.

Lactate accumulation inprimate spinal cord during circulatory arrest

1971 ◽  
Vol 34 (5) ◽  
pp. 618-620 ◽  
Author(s):  
Robert A. Feldman ◽  
David Yashon ◽  
George E. Locke ◽  
William E. Hunt
Keyword(s):  
Spinal Cord ◽  
Rhesus Monkeys ◽  
Circulatory Arrest ◽  
Lactate Production ◽  
Spinal Cord Tissue ◽  
Cerebral Tissue ◽  
Content Type ◽  
Lactate Accumulation ◽  
Relationship Of ◽  
The Relationship

✓ In rhesus monkeys subjected to circulatory arrest, studies were made of the relationship of lactate production in the spinal cord to the duration of circulatory arrest and magnitude of lactate accumulation, and the results were compared to the magnitude of rise in cerebral tissue lactate. Both high and low thoracic laminectomies were performed on each of eight rhesus monkeys. Spinal cord tissue was excised for lactate assay at the upper laminectomy as a control, and a second tissue specimen was excised at the lower laminectomy site at time increments of 30 sec to 30 min after circulatory arrest. Tissue was excised from each site without circulatory arrest in one monkey and showed negligible increase in lactate production, indicating that excision of tissue itself does not result in increased lactate. Nonanoxic samples from seven monkeys averaged 4.60 millimoles (mM)/lactate/kg tissue, with a range of 2.22 to 6.49. Postcirculatory arrest samples from these monkeys averaged 11.10 mM lactate/kg tissue, with a range of 3.62 (at 30 sec) to 14.33 (at 10 min). Anoxic spinal tissue lactate was elevated above controls in each instance, and tissue lactate peaked between 5 to 10 min after circulatory arrest and remained stable with mild fluctuations beyond that time. Thus, the spinal cord responds to circulatory arrest much as cerebral tissue, but with some delay in the accumulation of lactic acid.

scholarly journals Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

Endocrinology ◽  
2012 ◽  
Vol 153 (9) ◽  
pp. 4192-4203 ◽  
Author(s):  
Murielle M. Véniant ◽  
Renee Komorowski ◽  
Ping Chen ◽  
Shanaka Stanislaus ◽  
Katherine Winters ◽  
...  
Keyword(s):  
Body Weight ◽  
Rhesus Monkeys ◽  
Tolerance Test ◽  
Fibroblast Growth Factor 21 ◽  
Obese Mice ◽  
Compound A ◽  
Metabolic Properties ◽  
Long Acting ◽  
Relationship Of ◽  
Different Doses

Fibroblast growth factor 21 (FGF21), a hormone with short half-life, has consistently shown strong pharmacological efficacy. We first assessed the efficacy of murine recombinant FGF21 in C57BL6 lean mice for 5 wk. We then generated a long-acting FGF21 molecule by fusing a Fc to a variant of human recombinant FGF21 (hrFGF21) that contained two engineered mutations [L98R, P171G; Fc-FGF21(RG)] and tested it in C57BL6 diet-induced obese mice and obese rhesus monkeys. We compared its metabolic properties with those of the hrFGF21. Groups of diet-induced obese mice were treated for 36 d with different doses of hrFGF21 (01, 0.3, and 1 mg/kg twice daily) and with Fc-FGF21(RG) (2.3 mg/kg, every 5 d). Body weight, glucose, insulin, cholesterol, and triglyceride levels were decreased after treatment with either compound. A glucose tolerance test (GTT) was also improved. Obese rhesus monkeys were treated with hrFGF21 (once a day) and Fc-FGF21(RG) (once a week) in a dose-escalation fashion. Doses started at 0.1 and 0.3 mg/kg and ended at 3 and 5 mg/kg for hrFGF21 and Fc-FGF21(RG), respectively. Doses were escalated every 2 wk, and animals were followed up for a washout period of 3 wk. Body weight, glucose, insulin, cholesterol, and triglyceride levels and the GTT profile were decreased to a greater extent with Fc-FGF21(RG) than with hrFGF21. The PK-PD relationship of Fc-FGF21(RG) exposure and triglyceride reduction was also conducted with a maximum response model. In conclusion, in more than one species, Fc-FGF21(RG) chronically administered once a week showed similar or greater efficacy than hrFGF21 administered daily.

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