Onset of Protective Immunity in Chicks after Vaccination with a Recombinant Herpesvirus of Turkeys Vaccine Expressing Newcastle Disease Virus Fusion and Hemagglutinin-Neuraminidase Antigens

1996 ◽  
Vol 40 (4) ◽  
pp. 770 ◽  
Author(s):  
Robert A. Heckert ◽  
Jose Riva ◽  
Stephanie Cook ◽  
Janis McMillen ◽  
Roger D. Schwartz
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Protective Immunity ◽  
Herpesvirus Of Turkeys ◽  
Virus Fusion

scholarly journals Newcastle Disease Virus Fusion Protein Is the Major Contributor to Protective Immunity of Genotype-Matched Vaccine

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e74022 ◽  
Author(s):  
Shin-Hee Kim ◽  
Nanchaya Wanasen ◽  
Anandan Paldurai ◽  
Sa Xiao ◽  
Peter L. Collins ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Protective Immunity ◽  
Major Contributor ◽  
Virus Fusion

Protection of Chickens from Newcastle and Marek's Diseases with a Recombinant Herpesvirus of Turkeys Vaccine Expressing the Newcastle Disease Virus Fusion Protein

1992 ◽  
Vol 36 (4) ◽  
pp. 858 ◽  
Author(s):  
Robin W. Morgan ◽  
Jack Gelb ◽  
Christa S. Schreurs ◽  
Dieter Lutticken ◽  
John K. Rosenberger ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Herpesvirus Of Turkeys ◽  
Virus Fusion

scholarly journals Design and Characterization of Viral Polypeptide Inhibitors Targeting Newcastle Disease Virus Fusion

2005 ◽  
Vol 354 (3) ◽  
pp. 601-613 ◽  
Author(s):  
Jieqing Zhu ◽  
Xiuli Jiang ◽  
Yueyong Liu ◽  
Po Tien ◽  
George F. Gao
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Virus Fusion

scholarly journals Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range

2013 ◽  
Vol 94 (6) ◽  
pp. 1189-1194 ◽  
Author(s):  
Ingrid Cornax ◽  
Diego G. Diel ◽  
Cary A. Rue ◽  
Carlos Estevez ◽  
Qingzhong Yu ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Host Range ◽  
Cell Line ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Fibroblast Cell ◽  
Fibroblast Cell Line ◽  
Multifunctional Proteins ◽  
Virus Fusion ◽  
Chimeric Viruses

The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection. Here, we assessed the ability of NDV to replicate in macrophages and investigated the contribution of the F and HN proteins to NDV infection/replication in these cells. Results of our study revealed that, while presenting similar replication kinetics in a fibroblast cell line (DF1) or in primary non-adherent splenocytes, the NDV strain CA02 replicates better in macrophages (HD11 and primary adherent splenocytes) than the NDV strain Anhinga/93. Notably, exchange of the HN or both F and HN genes of NDV Anhinga/93 by the corresponding genes from NDV CA02 markedly improved the ability of the chimeric viruses to replicate in macrophages. These results indicate that the F and HN proteins are determinants of NDV macrophage host range. This represents the first description of productive NDV infection in macrophages.

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