Infectious Bursal Disease Viral Infections. I. Complement and Virus-Neutralizing Antibody Response Following Infection of Susceptible Chickens

1979 ◽  
Vol 23 (1) ◽  
pp. 95 ◽  
Author(s):  
J. K. Skeeles ◽  
P. D. Lukert ◽  
E. V. De Buysscher ◽  
O. J. Fletcher ◽  
J. Brown
Keyword(s):  
Antibody Response ◽  
Viral Infections ◽  
Neutralizing Antibody ◽  
Infectious Bursal Disease ◽  
Bursal Disease

scholarly journals Ascorbic acid supplementation improved antibody response to infectious bursal disease vaccination in chickens

2000 ◽  
Vol 79 (5) ◽  
pp. 680-688 ◽  
Author(s):  
J. Amakye-Anim ◽  
T.L. Lin ◽  
P.Y. Hester ◽  
D. Thiagarajan ◽  
B.A. Watkins ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Antibody Response ◽  
Infectious Bursal Disease ◽  
Acid Supplementation ◽  
Bursal Disease ◽  
Ascorbic Acid Supplementation

scholarly journals Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers

2021 ◽  
Vol 14 (1) ◽  
pp. 70-77
Author(s):  
Thotsapol Thomrongsuwannakij ◽  
Nataya Charoenvisal ◽  
Niwat Chansiripornchai
Keyword(s):  
Phylogenetic Analysis ◽  
Antibody Response ◽  
Vaccine Strain ◽  
Broiler Chickens ◽  
Humoral Response ◽  
Bursa Of Fabricius ◽  
Infectious Bursal Disease ◽  
Strain Group ◽  
Vaccine Responses ◽  
Bursal Disease

Background and Aim: Infectious bursal disease (IBD) or Gumboro disease is one of the most detrimental diseases in the poultry industry worldwide. Previous scientific studies have shown that live IBD vaccination might induce transient immunosuppression, leading to suboptimal vaccine responses, and therefore lack of protection against other infectious diseases; therefore, selecting an IBD vaccine in commercial farms is a concern. This study aims to compare two commercially attenuated IBD vaccines (intermediate and intermediate-plus strains) in terms of safety and antibody response to IBD and Newcastle disease viruses (NDV) in commercial broilers. Materials and Methods: Overall, 216 Cobb broiler chickens were divided into three groups based on the IBD vaccine strain administered: V217 strain (Group 1), M.B. strain (Group 2), and an unvaccinated group (Group 3). Groups 1 and 2 were orally vaccinated with Hitchner B1 NDV vaccine strain 7 days after IBD vaccination. Blood samples were collected at IBD vaccination day (15 days of age) and at 7, 14, 21, and 28 days post-IBD vaccination. The immunosuppressive effects of the IBD vaccination were determined by NDV antibody response, the bursa:body weight (B:BW) ratio, and the histopathological lesion scores of the bursa of Fabricius. Phylogenetic analysis was also performed. Results: Phylogenetic analysis revealed that the M.B. strain belonged to a very virulent IBD strain, whereas the V217 strain belonged to a classical IBD virus strain. NDV antibody titers of the two vaccinated groups increased after ND vaccination, reaching their maximum at 14 days post-ND vaccination and decreasing thereafter. The V217 group presented the highest NDV humoral response from 7 days post-vaccination (dpv) to the end of the study. The mean NDV antibody titer of the V217 group was significantly (p<0.05) higher than that of the M.B. group at 14 dpv. In addition, the V217 strain-induced lower bursal lesions post-IBD vaccination and a higher B:BW ratio at 7 and 21 dpv compared to the M.B. group. The higher B:BW ratio, lower bursal lesions, and higher ND antibody response present in the V217 group indicate that the V217 strain induces lower immunosuppressive effects compared to the M.B. strain. Conclusion: The results of this study indicate that IBD vaccine selection merits consideration, as avoiding the immunosuppressive effects induced by live IBD vaccination and the consequent impact on response to other vaccines is important.

scholarly journals MAVS regulates the quality of the antibody response to West-Nile Virus

2020 ◽  
Vol 16 (10) ◽  
pp. e1009009
Author(s):  
Marvin O’Ketch ◽  
Spencer Williams ◽  
Cameron Larson ◽  
Jennifer L. Uhrlaub ◽  
Rachel Wong ◽  
...  
Keyword(s):  
Immune Response ◽  
West Nile Virus ◽  
Antibody Response ◽  
Adaptive Immunity ◽  
Viral Infections ◽  
Adaptive Immune Response ◽  
Neutralizing Antibody ◽  
West Nile ◽  
Humoral Immune

A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are therefore critical to understand protective immunity to infections. West Nile virus (WNV) infection of mice deficent of RLR-signaling adaptor MAVS results in a defective adaptive immune response. While this finding suggests a role for RLRs in the instruction of adaptive immunity to WNV, it is difficult to interpret due to the high WNV viremia, associated exessive antigen loads, and pathology in the absence of a MAVS-dependent innate immune response. To overcome these limitations, we have infected MAVS-deficient (MAVSKO) mice with a single-round-of-infection mutant of West Nile virus. We show that MAVSKO mice failed to produce an effective neutralizing antibody response to WNV despite normal antibody titers against the viral WNV-E protein. This defect occurred independently of antigen loads or overt pathology. The specificity of the antibody response in infected MAVSKO mice remained unchanged and was still dominated by antibodies that bound the neutralizing lateral ridge (LR) epitope in the DIII domain of WNV-E. Instead, MAVSKO mice produced IgM antibodies, the dominant isotype controlling primary WNV infection, with lower affinity for the DIII domain. Our findings suggest that RLR-dependent signals are important for the quality of the humoral immune response to WNV.

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