Research Note: The Protective Effect Conferred by Pasteurella multocida Bacterin Administered Intranasally

1974 ◽  
Vol 18 (4) ◽  
pp. 631
Author(s):  
R. W. Wichmann ◽  
J. H. Stoner
Keyword(s):  
Protective Effect ◽  
Pasteurella Multocida ◽  
Research Note

scholarly journals Research Note: Response of Two Lines of Turkeys to Challenge with Pasteurella multocida

1988 ◽  
Vol 67 (12) ◽  
pp. 1807-1809 ◽  
Author(s):  
M.M. SHARAF ◽  
K.E. NESTOR ◽  
Y.M. SAIF ◽  
R.E. SACCO ◽  
G.B. HAVENSTEIN
Keyword(s):  
Pasteurella Multocida ◽  
Research Note

scholarly journals Protective effect of intranasal peste des petits ruminants virus and bacterin vaccinations: Clinical, hematological, serological, and serum oxidative stress changes in challenged goats

2019 ◽  
Vol 12 (7) ◽  
pp. 945-950
Author(s):  
Theophilus Aghogho Jarikre ◽  
Jeremiah Olalekan Taiwo ◽  
Benjamin Obukowho Emikpe ◽  
Stephen Owarioro Akpavie
Keyword(s):  
Protective Effect ◽  
Pasteurella Multocida ◽  
Glutathione Transferase ◽  
Clinical Signs ◽  
Vaccination Strategy ◽  
Peste Des Petits Ruminants ◽  
Mucosal Vaccination ◽  
Spectrophotometric Methods ◽  
Stress Changes ◽  
Hydrogen Peroxide Generation

Background and Aim: The current vaccination for peste des petits ruminants virus (PPRV) is stalled by myriad challenges and continuous endemicity of pneumonia due to fulminant bacterial complication in goats. The present study evaluated the protective effect of intranasal PPRV linage 1 and bacterine vaccinations. Materials and Methods: Twelve West African Dwarf (WAD) goats aged 6 months were randomly grouped and vaccinated within 2 weeks using a combination of PPRV lineage 1 vaccine (Nig/75), and bacterin from Mannheimia haemolytica (Mh) or Pasteurella multocida intranasally. The goats were observed for 3 weeks post-vaccination before comingled with a known infected WAD goat with apparent clinical signs of peste des petits ruminants and further observed clinically for 5 weeks post-infection (PI). Blood samples were taken for hematology while sera were assayed for antioxidants (glutathione peroxidase, glutathione transferase, and superoxide dismutase) activities and pro-oxidants (malondialdehyde content, reduced glutathione, hydrogen peroxide generation, and myeloperoxidase) using spectrophotometric methods. Data were subjected to parametric statistics at α=0.05 using GraphPad Prism version 21. Results: Clinically, there were pyrexia, oculonasal discharge, diarrhea, anemia, leukopenia, and increased pro-oxidants in the unvaccinated goats, while moderate neutrophilia and leukocytosis were observed in PPRV and bacterin vaccinated goats. Two unvaccinated goats were weak and euthanized at 13 and 28 days PI. The goats vaccinated with PPRV and Mh showed better response clinically and biochemically. Conclusion: The mucosal vaccination of goats with PPRV vaccine and bacterine will protect against exposure and culminate in the development of protective mucosal, humoral, and cell-mediated immune responses. This vaccination strategy will provide framework needed in the prevention and control of endemic caprine pneumonia in Nigeria.

scholarly journals Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1155
Author(s):  
Li-Jun Guan ◽  
Ji-Jian Song ◽  
Yun Xue ◽  
Xia Ai ◽  
Zhi-Jun Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Aluminum Hydroxide ◽  
Pasteurella Multocida ◽  
Protective Efficacy ◽  
Cross Protection ◽  
Immune Protection ◽  
Capsular Type ◽  
Protection Effect ◽  
Antibody Titers

Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model.

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