Memory for Pictures: A Life-Span Study of the Role of Visual Detail

1987 ◽  
Vol 58 (3) ◽  
pp. 807 ◽  
Author(s):  
Kathy Pezdek
Keyword(s):  
Life Span ◽  
Life Span Study ◽  
Visual Detail

Role of executive functions and processing speed in the age-related difference in episodic memory: A life span study

2010 ◽  
Author(s):  
Laurence Taconnat ◽  
Stephanie Billy ◽  
Cedric Bouquet ◽  
Agnes Blaye ◽  
Badiaa Bouazzaoui ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Executive Functions ◽  
Life Span ◽  
Processing Speed ◽  
Life Span Study ◽  
Related Difference ◽  
Age Related

Tumorigenesis in High-Dose Total Body Irradiated Rhesus Monkeys--A Life Span Study

2003 ◽  
Vol 31 (2) ◽  
pp. 209-213 ◽  
Author(s):  
Carel F. Hollander ◽  
Chris Zurcher ◽  
Johan J. Broerse
Keyword(s):  
Life Span ◽  
Rhesus Monkeys ◽  
High Dose ◽  
Life Span Study ◽  
Total Body

scholarly journals Loss of Ubp3 increases silencing, decreases unequal recombination in rDNA, and shortens the replicative life span in Saccharomyces cerevisiae

2014 ◽  
Vol 25 (12) ◽  
pp. 1916-1924 ◽  
Author(s):  
David Öling ◽  
Rehan Masoom ◽  
Kristian Kvint
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Rna Polymerase ◽  
Life Span ◽  
Rna Polymerase Ii ◽  
Ribosomal Dna ◽  
Genetic Evidence ◽  
Wild Type ◽  
Replicative Life Span ◽  
Unequal Recombination

Ubp3 is a conserved ubiquitin protease that acts as an antisilencing factor in MAT and telomeric regions. Here we show that ubp3∆ mutants also display increased silencing in ribosomal DNA (rDNA). Consistent with this, RNA polymerase II occupancy is lower in cells lacking Ubp3 than in wild-type cells in all heterochromatic regions. Moreover, in a ubp3∆ mutant, unequal recombination in rDNA is highly suppressed. We present genetic evidence that this effect on rDNA recombination, but not silencing, is entirely dependent on the silencing factor Sir2. Further, ubp3∆ sir2∆ mutants age prematurely at the same rate as sir2∆ mutants. Thus our data suggest that recombination negatively influences replicative life span more so than silencing. However, in ubp3∆ mutants, recombination is not a prerequisite for aging, since cells lacking Ubp3 have a shorter life span than isogenic wild-type cells. We discuss the data in view of different models on how silencing and unequal recombination affect replicative life span and the role of Ubp3 in these processes.

Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance

1995 ◽  
Vol 7 (2) ◽  
pp. 331-336 ◽  
Author(s):  
Judith Alferink ◽  
Birgit Schittek ◽  
Günter Schönrich ◽  
Günter J. Hämmerling ◽  
Bernd Arnold
Keyword(s):  
T Cells ◽  
Life Span ◽  
Peripheral Tolerance ◽  
Long Life

Spontaneous neoplasms of the seminal vesicles in aged Han:Chin hamsters (Cricetulus criseus)

1988 ◽  
Vol 22 (2) ◽  
pp. 127-130 ◽  
Author(s):  
J. Kaspareit-Rittinghausen ◽  
F. Deerberg
Keyword(s):  
Life Span ◽  
Seminal Vesicles ◽  
Natural Death ◽  
Life Span Study ◽  
Histopathological Features

Tumours of the seminal vesicles were found in 11 of 182 male Han:Chin hamsters kept in a life-span study from weaning to their natural death. Histologically they were classified as adenocarcinoma ( n = 10) and hemangiosarcoma ( n = 1). The histopathological features of the neoplasms are described.

scholarly journals Motivation as a Mediator of the Relation Between Cognitive Reserve and Cognitive Performance

2018 ◽  
Vol 75 (6) ◽  
pp. 1199-1205
Author(s):  
Fanny Vallet ◽  
Nathalie Mella ◽  
Andreas Ihle ◽  
Marine Beaudoin ◽  
Delphine Fagot ◽  
...  
Keyword(s):  
Intrinsic Motivation ◽  
Life Span ◽  
Cognitive Performance ◽  
Cognitive Processes ◽  
Cognitive Aging ◽  
Cognitive Reserve ◽  
Leisure Activities ◽  
Global Measure ◽  
Interindividual Differences

Abstract Objectives Interindividual differences in cognitive aging may be explained by differences in cognitive reserve (CR) that are built up across the life span. A plausible but underresearched mechanism for these differences is that CR helps compensating cognitive decline by enhancing motivation to cope with challenging cognitive situations. Theories of motivation on cognition suggest that perceived capacity and intrinsic motivation may be key mediators in this respect. Method In 506 older adults, we assessed CR proxies (education, occupation, leisure activities), motivation (perceived capacity, intrinsic motivation), and a global measure of cognitive functioning. Results Perceived capacity, but not intrinsic motivation, significantly mediated the relation between CR and cognitive performance. Discussion Complementary with neurobiological and cognitive processes, our results suggest a more comprehensive view of the role of motivational aspects built up across the life span in determining differences in cognitive performance in old age.

scholarly journals GABA receptors differentially regulate life span and health span in C. elegans through distinct downstream mechanisms

2019 ◽  
Vol 317 (5) ◽  
pp. C953-C963 ◽  
Author(s):  
Fengling Yuan ◽  
Jiejun Zhou ◽  
Lingxiu Xu ◽  
Wenxin Jia ◽  
Lei Chun ◽  
...  
Keyword(s):  
Life Span ◽  
Gaba Receptors ◽  
Health Span ◽  
Gaba A ◽  
Inhibitory Neurotransmitter ◽  
C Elegans ◽  
Physiological Processes ◽  
Gaba Signaling ◽  
Neuronal Functions

GABA, a prominent inhibitory neurotransmitter, is best known to regulate neuronal functions in the nervous system. However, much less is known about the role of GABA signaling in other physiological processes. Interestingly, recent work showed that GABA signaling can regulate life span via a metabotropic GABAB receptor in Caenorhabditis elegans. However, the role of other types of GABA receptors in life span has not been clearly defined. It is also unclear whether GABA signaling regulates health span. Here, using C. elegans as a model, we systematically interrogated the role of various GABA receptors in both life span and health span. We find that mutations in four different GABA receptors extend health span by promoting resistance to stress and pathogen infection and that two such receptor mutants also show extended life span. Different GABA receptors engage distinct transcriptional factors to regulate life span and health span, and even the same receptor regulates life span and health span via different transcription factors. Our results uncover a novel, profound role of GABA signaling in aging in C. elegans, which is mediated by different GABA receptors coupled to distinct downstream effectors.

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