scholarly journals Accidental colchicine poisoning with fatal outcome after ingestion of meadow saffron (Colchicum autumnale L.) - Report of autopsy case

2020 ◽  
Vol 77 (10) ◽  
pp. 1104-1108
Author(s):  
Milos Danilovic ◽  
Jelena Isailovic ◽  
Ivan Aleksic ◽  
Jelena Dzambas ◽  
Nadica Marinkovic
Keyword(s):  
Myocardial Fibrosis ◽  
Brain Oedema ◽  
Fatal Outcome ◽  
Wild Plants ◽  
Coagulation Necrosis ◽  
Histopathological Analysis ◽  
Herbaceous Plant ◽  
Colchicum Autumnale ◽  
Colchicine Poisoning ◽  
Wild Garlic

Introduction. Meadow saffron (Colchicum autumnale L.) is a perennial herbaceous plant belonging to the Lily family (Liliacea). It is similar to the edible wild garlic (Allium ursinum L.). Toxic substance in meadow saffron is alkaloid colchicine. Colchicine poisoning is a very dangerous condition which can lead to a fatal outcome. Case report. A 50-yearsold male was addmited to the hospital complaining of weakness, abdominal pain, nausea, vomiting and diarrhea without blood. The day before, the patient ate two plants thinking they were wild garlic and seven hours after ingestion he felt first symptoms. During the course of the hospital stay, he had gastroenterocolitis, acute renal faliure, hepatic lesions and cardiorespiratory insufficiency with a fatal outcome. Post-mortem examination revealed: brain oedema, lung oedema and congestion, heart weighing 700 g with ventricular hypertrophy, myocardial fibrosis, liver congestion and steatosis, spleen congestion, pancreatic fibrosis. Organs sections were taken for histopathological analysis. Body fluids and parts of organs were toxicologically analyzed. Histopathological findings were: brain oedema, diffuse perivascular and interstitial myocardial fibrosis, myocardial haemorrhage, lungs congestion and oedema, microvesicular and macrovesicular liver steatosis, centrilobular liver necrosis, lymphocytic inflammatory infiltrate in liver portions, red pulp congestion of the spleen, kidney congestion and interstitial bleeding, coagulation necrosis of the proximal tubules of the kidney. Toxicological analysis showed colchicine in the blood ? 0.011 mg/L, urine ? 0.051 mg/L, liver with gallbladder ? 0.007 mg/kg, kidney ? 0.008 mg/kg. Conclusion. Ingestion of meadow saffron can lead to poisoning with a fatal outcome due to the presence of the alkaloid colchicine. Colchicine intoxication should be suspected in patients with gastrointestinal symptoms after consuming wild plants.

Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects

1999 ◽  
Vol 106 (3) ◽  
pp. 191-200 ◽  
Author(s):  
Michael Klintschar ◽  
Christine Beham-Schmidt ◽  
Herbert Radner ◽  
Gerald Henning ◽  
Peter Roll
Keyword(s):  
Accidental Ingestion ◽  
Medicolegal Aspects ◽  
Colchicum Autumnale ◽  
Colchicine Poisoning

scholarly journals A case of cardiomyopathy in the course of colchicine poisoning due to accidental ingestion of Colchicum autumnale

2022 ◽  
Vol 29 (1) ◽  
pp. 43-44
Author(s):  
Tatsuya Yokoyama ◽  
Ikuto Otsuki ◽  
Tomohiko Kimijima ◽  
Ryoichi Kawaguchi ◽  
Kazuto Takakuwa ◽  
...  
Keyword(s):  
Accidental Ingestion ◽  
Colchicum Autumnale ◽  
Colchicine Poisoning

scholarly journals Protective effects of resveratrol on kidney function tests and renal histopathology in carbon tetrachloride-induced renal toxicity in rats

2021 ◽  
Vol 10 (1) ◽  
pp. 156-161
Author(s):  
Volkan Gelen ◽  
Emin Şengül
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Kidney Function ◽  
Coagulation Necrosis ◽  
Albino Rats ◽  
Histological Structure ◽  
Histopathological Analysis ◽  
Kidney Function Tests ◽  
Hydropic Degeneration ◽  
Function Tests

In this study, it was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology. For this purpose, 32 male Wistar Albino rats were used. The subjects were randomly selected, 1st group control, 2nd group CCl4, 3rd group Resveratrol. The 4th group was divided into 4 groups as CCl4 + Resveratrol. At the end of the experiment, animals were sacrificed under anesthesia and kidney samples were taken in 10% formalin solution for histopathological analysis. In the histopathological examination, it was found that the rats in the control and Resveratrol groups had normal kidney histological structure. In CCI4 group, severe hydropic degeneration in tubules epithelium, mild coagulation necrosis in tubules epithelium and severe hyperemia in the vessels were observed. When kidney tissues of rats were examined in CCI4 + Resveratrol group, mild hydropic degeneration in tubules epithelium and mild hyperemia in vessels were observed. When the kidney tissues of the rats in the Resveratrol group were examined, it was observed that they had a normal histological appearance. As a result, it was determined that Resveratrol has a protective effect on kidney damage caused by CCI4.

Colchicine Poisoning Resulting from Accidental Ingestion of Meadow Saffron (Colchicum Autumnale)

2002 ◽  
Vol 47 (6) ◽  
pp. 15581J ◽  
Author(s):  
S. Sannohe ◽  
Y. Makino ◽  
T. Kita ◽  
N. Kuroda ◽  
T. Shinozuka
Keyword(s):  
Accidental Ingestion ◽  
Colchicum Autumnale ◽  
Colchicine Poisoning

scholarly journals Fatal outcome in the patient with the suspected ectopic pregnancy and diagnosed epithelioid trophoblastic tumor

2019 ◽  
Vol 76 (10) ◽  
pp. 1082-1086
Author(s):  
Aleksandar Dobrosavljevic ◽  
Branka Nikolic ◽  
Rastko Maglic ◽  
Ivana Petrovic ◽  
Goran Stankovic
Keyword(s):  
Surgical Treatment ◽  
Ectopic Pregnancy ◽  
Fatal Outcome ◽  
Team Work ◽  
Histopathological Analysis ◽  
Inadequate Response ◽  
Adequate Treatment ◽  
Trophoblastic Tumor ◽  
Response To Chemotherapy ◽  
Epithelioid Trophoblastic Tumor

Introduction. Epithelioid trophoblastic tumor (E??) is an extremely rare form and unusual type of trophoblastic tumor. In 1998 ??? became an independent entity because it possesses specific histological and immunohistochemical features which make it different from placental site tumor and choriocarcinoma. ??? origins from intermediate trophoblast and it can overlap with the squamous cell carcinoma as per differential diagnosis. The relevant literature data suggest that surgical treatment is a treatment of choice for ETT considering that its response to chemotherapy is considerably poor. Case report. A 35-years-old patient G3 P2 came to an examination due to the low pelvic pain and absence of menstrual cycle. She reported that menstrual cycles were irregular during the past year. During the bimanual pelvic examination, a painful tumefaction being approximately 8 cm was palpated in the pouch of Douglas. The patient was operated on as being suspected for ectopic pregnancy when it was noticed that the aforementioned tumefaction was located retroperitoneally immediately against rectosigmoid part of the colon. After the histopathological analysis of the sample, in order to make the final diagnosis, the immunohistochemical test was performed and it found that this E??. Due to an inadequate response to administered chemotherapy, both resection of rectosigmoid colon with appurtenant tumor and left hepatectomy with salpingectomy on both sides were performed considering a possibility of gestational trophoblastic neoplasia (GTN) after ectopic pregnancy. Because of dehiscence of colorectal anastomosis, relaparotomy with colostomy bag fitting was performed. The patient died on the day 40 after surgical treatment due to hepatic insufficiency. Conclusion. In order to make as much adequate treatment method of ETT as possible, it is necessary to organize a team work with multidisciplinary approach. Surgical resection of the tumor is a primary method for treating ETT.

Isolating Colchicine in 19th Century: An Old Drug Revisited

2018 ◽  
Vol 24 (6) ◽  
pp. 654-658 ◽  
Author(s):  
Marianna Karamanou ◽  
Gregory Tsoucalas ◽  
Konstantinos Pantos ◽  
George Androutsos
Keyword(s):  
Atrial Fibrillation ◽  
Familial Mediterranean Fever ◽  
19Th Century ◽  
Therapeutic Efficacy ◽  
Behcet’S Disease ◽  
Herbaceous Plant ◽  
Colchicum Autumnale ◽  
Trade Name ◽  
Mediterranean Fever ◽  
First Time

Colchicine is a tricyclic alkaloid extracted from the herbaceous plant Colchicum autumnale. Known since antiquity for its therapeutic efficacy in the treatment of gout, colchicine was reintroduced in 19th century pharmacopeia, thanks to the work of the French chemists and pharmacists Pierre-Joseph Pelletier (1788-1842) and Joseph Bienaimé Caventou (1795-1877) who in 1819, isolated a peculiar substance in the roots of Colchicum autumnale. In 1833, the substance was further analyzed by the German pharmacist and chemist Philipp Lorenz Geiger (1785-1836), who coined the name colchicine. In 1884, the French pharmacist Alfred Houde (1854-1919) produced for the first time pure crystallized colchicine in granules of 1milligram which is still sold under this trade name in several countries. In the last two centuries, colchicine's indications were furthermore expanded. From anti-gout drug during antiquity and a diuretic in 19th century, colchicine is currently administered in several affections such as Adamantiades-Behcet's disease, familial Mediterranean fever, pericarditis and atrial fibrillation.

scholarly journals Colchicine poisoning due to accidental ingestion of Colchicum autumnale: a case report

2018 ◽  
Vol 25 (1) ◽  
pp. 47-48
Author(s):  
Masakazu Kobayashi ◽  
Yuta Yokokawa ◽  
Koji Hara ◽  
Noriko Miyagawa ◽  
Motoo Fujita ◽  
...  
Keyword(s):  
Case Report ◽  
Accidental Ingestion ◽  
Colchicum Autumnale ◽  
Colchicine Poisoning

scholarly journals Er:YAG laser-assisted filtration surgery: initial results in rabbits

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Noa Kapelushnik ◽  
Ari Leshno ◽  
Reut Singer ◽  
Ruth Huna-Baron ◽  
Yaniv Barkana ◽  
...  
Keyword(s):  
Er:Yag Laser ◽  
Laser System ◽  
Pulse Length ◽  
Glaucoma Surgery ◽  
Coagulation Necrosis ◽  
Histopathological Analysis ◽  
Subconjunctival Injection ◽  
A Minor ◽  
Ab Interno

Abstract Background Glaucoma is a leading cause of global blindness, especially preventable blindness. The increased prevalence of glaucoma has led to a growing demand for newer, safer, more rapid, and simpler treatments for the reduction of intraocular pressure (IOP). In this study, we evaluated the safety and feasibility of performing filtration glaucoma surgery with an Ab-Interno Er:YAG laser in rabbits. Methods Nine New Zealand White rabbits age 16 weeks were studied. After subconjunctival injection of mitomycin C (MMC), a novel Ab-Interno Er:YAG laser probe was inserted into the anterior chamber (AC) through a clear corneal 1 mm paracentesis and directed at the trabecular meshwork adjacent to the MMC injection area. A pulsed laser beam was applied to create a patent sclerostomy connecting the AC to the subconjuctival space, resulting in a filtering bleb. The laser system used was the Er:YAG laser system - LAS25-FCU, (Pantec Biosolutions AG, Liechtenstein). Parameters used: Wave lengh: 2940 nm, Pulse length: 100–400 μsec,frequency: 250 Hz. Average laser power in accordance to the fiber tip diameter: 0.85 W(range 0.8–0.92 W). Complete ocular exams, including IOP measurements, were performed on 1, 7, 14, and 23 days postoperatively. Three rabbits were sacrificed on days 1, 14, and 23, and histological examinations were performed on all nine eyes. Results All procedures resulted in a functional medium-large superior bleb without significant complications. The bleb was sustained in all rabbits by day 14 and in one of the three rabbits that reached the last follow-up at 23 days. No cases of postoperative hypotony were observed. There was a transient significant reduction in mean IOP on postoperative days 5 and 7 (P = 0.028). Histopathological analysis revealed a patent full-thickness scleral tunnel with only a minor degree of surrounding coagulation necrosis. Conclusions The Ab-Interno laser sclerostomy procedure is potentially safe and effective based on initial experience in an in-vivo rabbit animal model.

Metabolic signalling and the partitioning of resources in plant storage organs

1999 ◽  
Vol 133 (3) ◽  
pp. 243-249 ◽  
Author(s):  
NIGEL G. HALFORD
Keyword(s):  
Dry Weight ◽  
Wild Relatives ◽  
Crop Plants ◽  
Wild Plants ◽  
Young Plant ◽  
Carbon And Nitrogen ◽  
Cultivated Potato ◽  
Metabolic Signalling ◽  
Storage Organs ◽  
Plant Storage

The most important harvested organs of crop plants, such as seeds, tubers and fruits, are often described as assimilate sinks. They play little or no part in the fixation of carbon through the production of sugars through photosynthesis, or in the uptake of nitrogen and sulphur, but import these assimilated resources to support metabolism and to store them in the form of starch, oils and proteins. Wild plants store resources in seeds and tubers to later support an emergent young plant. Cultivated crops are effectively storing resources to provide us with food and many have been bred to accumulate much more than would be required otherwise. For example, approximately 80% of a cultivated potato plant's dry weight is contained in its tubers, ten times the proportion in the tubers of its wild relatives (Inoue & Tanaka 1978). Cultivation and breeding has brought about a shift in the partitioning of carbon and nitrogen assimilate between the organs of the plant.

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