scholarly journals The changes of oxidative stress and endothelial function biomarkers after 6 weeks of aerobic physical training in patients with stable ischemic coronary disease

2017 ◽  
Vol 74 (11) ◽  
pp. 1060-1065
Author(s):  
Boris Djindjic ◽  
Zoran Radovanovic ◽  
Tomislav Kostic ◽  
Djindjic Natasa ◽  
Marko Lazovic
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Heart Rate ◽  
Endothelial Function ◽  
Cardiac Rehabilitation ◽  
G Proteins ◽  
Physical Training ◽  
Interquartile Range ◽  
Cardiovascular Rehabilitation ◽  
Ischemic Coronary Disease

Introduction: Exercise-based cardiac rehabilitation improves endothelialBackground/Aim. Exercise-based cardiac rehabilitation improves endothelial function, reduces cardiac mortality and anginal symptoms in patients with established cardiovascular disease. We evaluated the changes of oxidative stress and endothelial function biomarkers after 6 weeks of aerobic physical training in patients with stable ischemic coronary disease (IHD) participating in a cardiovascular rehabilitation exercise program. Methods. Thirty-five patients with stable IHD engaged in cardiovascular rehabilitation program with the regular aerobic physical activity during 6 weeks were consecutively included together with 37 control, age and sex-matched, IHD patients with a sedentary lifestyle. Clinical data about anthropometric and cardiovascular parameters and laboratory data: serum cell adhesion molecules intracellular (sICAM-1) and vascular (sVCAM-1), reactive carbonyl derivatives (RCD), lipid peroxidation products malondialdehyde (MDA) and nitric oxide (NO) concentration were determined at the beginning and after 6 weeks of aerobic training (45 minutes of continuous exercise up to 80% of maximal heart rate, 3 times a week). Results. The baseline characteristics of examined groups were similar according to age, gender, and cardiovascular risk profiles. The regular aerobic physical activity induced significant reduction of body mass index, blood pressure, heart rate, triglycerides, RCD (1.27 ? 0.48 ?mol/g proteins vs. 1.04 ? 0.22 ?mol/g proteins), sVCAM-1 [100.4, interquartile range (IQR)(78.4?118.3) ng/mL vs. 80.0 IQR(68.5?97.2 ng/mL)] and increasing of NO (64.72 ? 16.06 nmol/mg proteins vs. 74.38 ? 18.57 nmol/mg proteins) and HDL cholesterol (p < 0.05), which was not seen in sedentary control RCD (1.16 ? 0.25 interquartile range vs. 1.12 ? 0.14 interquartile range), sVCAM-1 [92.2 IQR (73.6?106.8 ng/mL) vs. 91.3 IQR (73.0?105.3 ng/mL) and NO (68.5 ? 17.9 nmol/mg vs. 65.7 ? 19.6). The values of sICAM-1 were lower in exercise training group baseline without significant changes during observation [80.74 IQR (54.92?97.3) vs. 80.36 IQR (68.1?95.3)] compared to the control

scholarly journals The effects of physical training on cardiovascular parameters, lipid disorders and endothelial function

2012 ◽  
Vol 69 (11) ◽  
pp. 956-960 ◽  
Author(s):  
Goran Rankovic ◽  
Natasa Djindjic ◽  
Gorana Rankovic-Nedin ◽  
Sasa Markovic ◽  
Dragan Nejic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Exercise Training ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Physical Training ◽  
Training Period ◽  
Cardiovascular Parameters ◽  
Group I ◽  
Cardiovascular Rehabilitation

Bacground/Aim. Regular physical activity is widely accepted as factor that reduces all-cause mortality and improves a number of health outcomes. The aim of this study was to investigate the effects of aerobic exercise training on cardiovascular parameters, lipid profile and endothelial function in patients with stable coronary artery disease (CAD). Methods. The study included seventy patients with stable CAD. All the patients were divided into two groups: the group I - 33 patients with CAD and with regular aerobic physical training during cardiovascular rehabilitation program phase II for 3 weeks in our rehabilitation center and 3 weeks after that in their home setting, and the group II (control) - 37 patients with CAD and sedentary lifestyle. Exercise training consisted of continual aerobic exercise for 45 minutes on a treadmill, room bicycle or walking, three times a week. We determined lipid and cardiovascular parameters and nitric oxide (NO) concentration at the beginning and after a six-week of training. Results. There were no significant differences in body weight, waist circumference and waist/hip ratio at the start and at the end of physical training program. Physical training significantly reduced body mass index after six weeks compared to the initial and control values. Physical training significantly reduced systolic and diastolic blood pressure and heart rate after a six-week training period (p < 0.05). Heart rate was significantly lower after a training period as compared to the control (p < 0.05). A significant reduction of triglyceride and increased high density lipoprotein cholesterol (HDL-C) concentration after cardiovascular rehabilitation were registered (p < 0.05). The concentration of triglycerides was significantly lower while NO and HDL-C were higher after six weeks in the exercise training group (p < 0.05). Conclusion. Dynamic training can improve blood pressure in patients with moderate to severe hypertension and reduce the need for medication. Exercise programs induced favorable adaptations on lipoproteins profile, cardiovascular parameters and endothelial function which are clinically desirable in primary and secondary prevention of CAD.

Depression and Heart Rate Variability in Cardiac Rehabilitation Patients: Exploring the Roles of Physical Activity and Fitness

2010 ◽  
Vol 111 (2) ◽  
pp. 608-624 ◽  
Author(s):  
Joel W. Hughes ◽  
Elizabeth Casey ◽  
Vicki H. Doe ◽  
Ellen L. Glickman ◽  
Phyllis K. Stein ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Rehabilitation

Dynamics of the heart rate response to sinusoidal work in humans: influence of physical activity and age

2001 ◽  
Vol 102 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Yoshiyuki FUKUOKA ◽  
Yoko NAKAGAWA ◽  
Katsutoshi OGOH ◽  
Tomoyuki SHIOJIRI ◽  
Yoshiyuki FUKUBA
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Physical Training ◽  
Linear Regression Analysis ◽  
Nervous Activity ◽  
Peak Oxygen Uptake ◽  
Sympathetic Nervous Activity ◽  
Training Status ◽  
Mean Response Time ◽  
Age Range

The purpose of the present study was to define the influence of age and exercise training on the heart rate (HR) dynamic response (i.e. kinetics) to sinusoidal work. A total of 63 healthy subjects (31 men and 32 women; age range 19-69 years) underwent a three-step incremental work test, during which peak oxygen uptake (o2peak) was estimated by the YMCA method. Sinusoidal work varying between 20% and 60% of HRreserve was employed for periods of 1, 3, 6, 9 and 12min. HR was monitored in a beat-by-beat manner with a cardiotachometer. The kinetics of the HR response were analysed by frequency analysis and estimated by a first-order transfer function with time constant (τ) and time delay (TD). Physical training status was estimated as stepping frequency, as measured with a pedometer during the daytime, and averaged over seven consecutive days. The mean response time of HR kinetics (HRMRT: τ pulse TD) tended to increase gradually with age (0.36sċyear-1), and linear regression analysis revealed that the correlation between HRMRT and age was significant (r = 0.31, P < 0.05), although not as highly significant as that between HRMRT and physical activity (r =-0.48, P < 0.0001). HRMRT was not related to the S.D. of HR variation (an indicator of parasympathetic mediation) at rest. In addition, o2peak showed a significantly greater correlation with age (r =-0.60, P < 0.0001) than with physical activity (r =-0.14, not significant). In conclusion, these findings suggest that HR dynamics, which may depend on sympathetic nervous activity, are more sensitive to physical activity than to age, but that o2peak, as estimated by the age-associated decline in maximum HR, is unrelated to physical training status.

scholarly journals Heart Rate Reduction by Ivabradine Reduces Oxidative Stress, Improves Endothelial Function, and Prevents Atherosclerosis in Apolipoprotein E–Deficient Mice

Circulation ◽  
2008 ◽  
Vol 117 (18) ◽  
pp. 2377-2387 ◽  
Author(s):  
Florian Custodis ◽  
Magnus Baumhäkel ◽  
Nils Schlimmer ◽  
Franka List ◽  
Christoph Gensch ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Endothelial Function ◽  
Apolipoprotein E ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Deficient Mice

scholarly journals Atrial Fibrillation: the Association with Physical Activity and the Effects of Cardiac Rehabilitation

2020 ◽  
Vol 16 (5) ◽  
pp. 804-814
Author(s):  
M. G. Bubnova ◽  
D. M. Aronov
Keyword(s):  
Physical Activity ◽  
Atrial Fibrillation ◽  
Cardiac Rehabilitation ◽  
Physical Training ◽  
Standard Therapy ◽  
Physical Rehabilitation ◽  
Control Group ◽  
Rehabilitation Programs ◽  
Number Of Patients ◽  
The Impact

The purpose of this review was to present modern studies that examine the relationship of physical activity and risk of atrial fibrillation (AF) development and the impact of cardiac rehabilitation programs in patients with all forms of AF. Data of 52 Russian and foreign scientific sources published in 1998- 2020 were presented. In our study, 48 patients with paroxysmal AF after radiofrequency ablation (RFA) were randomly assigned to a physical rehabilitation/standard therapy or control (standard therapy) group. Aerobic physical training was conducted for 6 months 3 times a week. AF is one of the most common cardiac arrhythmias. Despite modern advances, results of treatment of this disease are far from optimal. Many problems of patients with AF can be addressed through enrolment in multidisciplinary cardiac rehabilitation programs. But this question remains open. This is mainly due to the complexity of selection of physical rehabilitation program for patients with AF. It is known that physical activity can trigger an episode of AF. In the following review article, the approaches to functional capacity assessment of patient with AF are described, recommendations for prescribing safe exercise training to achieve a therapeutic effect are presented. Various aspects of the effects of physical rehabilitation are discussed, including its impact on cardiovascular risk factors, influence on atrial remodeling processes and associated biomarkers, prevention of AF progression and occurrence of cardiovascular complications. Results of our own research indicate effectiveness of physical training in patients with AF after RFA: increase in exercise duration by 18.6% (p<0.001) and load by 24.8% (p<0.01) during exercise test, increase in level of everyday physical activity by 23.8% (p=0.001); left atrium dimensions remain stable comparing with control group. That was combined with a decrease of post ablation atrial arrhythmias: after 6 months, they were registered in 4.5% of trained patients vs 17.4% of control group patients (p<0.01). Steady growth in the number of patients with AF and catheter ablation procedures around the world dictates the need for organization of multi-purpose medical rehabilitation.

scholarly journals Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Akinjide Moses Akinnuga ◽  
Angezwa Siboto ◽  
Bongiwe Khumalo ◽  
Ntethelelo Hopewell Sibiya ◽  
Phikelelani Ngubane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lipid Peroxidation ◽  
Heart Rate ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Lipid Profile ◽  
Cardiovascular Function ◽  
Male Rats ◽  
Cardiovascular Dysfunction

Prediabetes is an intermediate hyperglycaemic state which has been associated with cardiovascular dysfunction. However, cardiovascular dysfunction is not only caused by intermediate hyperglycaemia but also endothelial dysfunction, inflammation, and oxidative stress associated with prediabetes. Bredemolic acid (BA), an isomer of maslinic acid, has been reported to ameliorate the intermediate hyperglycaemia found in prediabetes; however, the effects of this triterpene on cardiovascular function have not yet been determined. Therefore, this study investigated the effects of BA on cardiovascular function in diet-induced prediabetic rats. Thirty-six male rats that weighed 150–180 g were divided into two groups, the non-prediabetic (n = 6) and the prediabetic groups (n = 30), which were fed normal diet (ND) and HFHC diet, respectively. The prediabetic rats were further subdivided into five groups (n = 6) and treated with either BA (80 mg/kg) or metformin (MET, 500 mg/kg) every third day for 12 weeks. After 12 weeks, blood samples and the heart were collected for biochemical analysis. The untreated prediabetic rats showed a significant increase in body mass index (BMI), waist circumference (WC), blood pressure, heart rate, lipid profile, lipid peroxidation, and inflammatory markers with significant decrease in endothelial function and antioxidant biomarkers by comparison with the non-prediabetic animals. The administration of BA significantly improved cardiovascular functions such as blood pressure, heart rate, and endothelial function. There was also a significant decrease in BMI, WC, lipid profile, lipid peroxidation, and inflammation with a concomitant increase in antioxidant capacity. BA administration improved cardiovascular function by attenuation of oxidative stress, inflammatory, and endothelial dysfunction markers.

scholarly journals Vascular Function in Patients After Myocardial Infarction: The Importance of Physical Activity

2021 ◽  
Vol 12 ◽  
Author(s):  
Jure Tršan ◽  
Daniel Košuta ◽  
Uroš Rajkovič ◽  
Zlatko Fras ◽  
Borut Jug ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Cardiac Rehabilitation ◽  
Physical Activity Level ◽  
Vascular Function ◽  
Activity Level ◽  
Activity Engagement

Background: Patients after myocardial infarction have impaired vascular function. However, effects of lifestyle, e.g., physical activity level, on endothelial function and arterial stiffness remain scarce. The aim of our study was to investigate effects of physical activity level and risk factors on endothelial function and arterial stiffness.Methods: In this cross-sectional study, we ultrasonographically assessed parameters of vascular function, namely flow mediated dilation (FMD) of the brachial artery and carotid artery stiffness in patients after myocardial infarction referred to the cardiac rehabilitation. The International Physical Activity Questionnaire (IPAQ) was obtained from all participants. Based on the IPAQ, patients were classified into three groups: vigorous, moderate, and low physical activity engagement. ANOVA was used for comparison among three groups using Bonferroni correction to determine differences between two sub-groups.Results: One hundred and eight patients after myocardial infarction (mean age 53 ± 10 years) were included. There were significant differences in terms of FMD (8.2 vs. 4.2 vs. 1.9%, p &lt; 0.001) and pulse wave velocity (PWV), a measure of arterial stiffness (6.1 vs. 6.4 vs. 6.9 m/s, p = 0.004) among groups of vigorous, moderate, and low physical activity engagement, respectively. However, in younger patients only FMD remained associated with physical activity level, while arterial stiffness was not. Low physical activity engagement was a significant predictor of both FMD and PWV in univariate and multivariate models, adjusted for age, sex, and other risk factors.Conclusion: Low physical activity level is associated with impaired endothelial function and increased arterial stiffness in patients after myocardial infarction. Future studies are warranted to address this issue in a context of cardiac rehabilitation protocols optimization in order to improve vascular function in these patients.

scholarly journals Effects of physical exercise on inflammatory parameters and risk for repeated acute coronary syndrome in patients with ischemic heart disease

2009 ◽  
Vol 66 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Goran Rankovic ◽  
Branislava Milicic ◽  
Todorka Savic ◽  
Boris Djindjic ◽  
Zorica Mancev ◽  
...  
Keyword(s):  
Physical Activity ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Physical Exercise ◽  
Physical Training ◽  
Home Setting ◽  
Coronary Syndrome ◽  
Markers Of Inflammation ◽  
Cardiovascular Rehabilitation ◽  
Increased Risk

Background/Aim. Inflammation is an important factor in the pathogenesis of atherosclerosis, and several markers of inflammation have been associated with an increased risk of cardiovascular events. Physical activity may lower the risk for coronary heart disease (CHD) by mitigating inflammation. The aim of this study was to investigate the effects of aerobic physical exercise on systemic inflammatory response in patients with stable coronary disease participating in a cardiovascular rehabilitation exercise program. Methods. Male (n = 29) and female (n = 23) patients with stable coronary heart disease were enrolled in this study. All the patients were divided into two groups: the group with regular aerobic physical training during cardiovascular rehabilitation program phase II for 3 weeks in our rehabilitation center and 3 weeks after that in their home setting, and sedentary lifestyle group. There were no significant differences in gender distribution among the analyzed groups. Student's t-test showed no significant differences in average age, waist circumference (OS) and waist/hip ratio (WHR). Results. The degree of obesity was measured by BMI and there was a significant improvement in BMI in the patients who undertook 6-week physical training compared to the controls (p < 0.05). Physical training during 6-week appeared not to have any effects on leukocite count and ICAM-1 levels compared to controls. Exercise induced reduction in plasma CRP levels by 23.72% (p < 0.001) and reduction in plasma VCAM-1 levels by 10.23%, (p < 0.05). Conclusion. Moderate aerobic exercise resulted in a significant reduction of inflammatory state by decreasing CRP and VCAM-1 levels with significant obesity reduction but without visceral obesity reduction. The obtained results indicate that regular physical activity is clinically desirable in primary and secondary prevention of coronary heart diseases.

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