scholarly journals Time trend and clinical pattern of extrapulmonary tuberculosis in Serbia, 1993-2007

2012 ◽  
Vol 69 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Dragica Pesut ◽  
Milica Bulajic ◽  
Aleksandar Lesic
Keyword(s):  
Incidence Rate ◽  
Census Data ◽  
Economic Transition ◽  
Transition Period ◽  
Extrapulmonary Tuberculosis ◽  
High Coverage ◽  
Female Ratio ◽  
Bcg Vaccination ◽  
Tb Treatment ◽  
Directly Observed Treatment

Background/Aim. Increased incidence of extrapulmonary tuberculosis (XPTB) is reported worldwide. Serbia is a country in socio-economic transition period with lowmiddle HIV prevalence and intermediate-to-low tuberculosis (TB) incidence rate, 100% directly observed treatment (DOT) coverage, and mandatory BCG vaccination at birth. The aim of the study was to examine the incidence trend and clinical features of XPTB in Serbia during a 15-year period. Methods. This retrospective observational study included XPTB cases diagnosed in the period between 1st January 1993 and 31st Decembre 2007, according to the reports of the National Referral Institute of Lung Diseases and Tuberculosis in Belgrade and Central Tuberculosis Register. Population estimates with extrapolations were based on 1991 and 2002 census data. Results. While the overall TB incidence rate showed a slight, not significant decreasing trend (p = 0.535), a significant increase was found for XPTB (y = 1.7996 + 0.089x; R2 = 0.4141; p = 0.01). A total of 2,858 XPTB cases (newly diagnosed and 10% relapses) gave an average age specific incidence rate of 2.51/100,000 population (95% confidence interval, SD = 0.6182) with 8.9% annual increase. The male-to-female ratio was 0.54. Lymph nodes were most frequently affected site (48.5%) followed by genitourinary (20.5%), pleural (12%), and osseo-arthicular (10.3%) TB. Treatment outcome was successful in 88.29% of patients (cured and completed), 3.64% died, 5.18% interrupted, 0.57% displaced, and 2.3% unknown. Conclusion. Increasing trend of XPTB incidence rate may be a result of increased morbidity due to still present risk factors, possible higher detection rate in Serbia and better notification. A high coverage of newborns with BCG vaccination at birth might contribute to a decreased number and rare XPTB cases in children.

Sociodemographic, Clinical Profile and Outcome of Tuberculosis in Baramulla District of North Kashmir of India

JMS SKIMS ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 11-16
Author(s):  
Abdul Ahad Wani ◽  
Javeed Iqbal Bhat ◽  
Muzafar Naik ◽  
Nisar Ahmed Dar ◽  
Syed Masood Ahmed
Keyword(s):  
Elementary Education ◽  
Pulmonary Tuberculosis ◽  
Rural Areas ◽  
Extrapulmonary Tuberculosis ◽  
Steady Increase ◽  
Female Ratio ◽  
Directly Observed Treatment ◽  
Night Sweats ◽  
Immunodeficiency Syndrome ◽  
A Prospective Study

Background: India accounts for one-fourth of the global tuberculosis (TB) burden. Since the countrywide implementation of RNTCP, tuberculosis care has received renewed focus. Directly observed treatment short-term (DOTS) is a cornerstone of RNTCP program. Objective: To evaluate demographic profile, clinical presentation and outcome of TB in district Baramulla of North Kashmir. Methods:  A prospective study over a period of seven years in patients diagnosed with TB in district Baramulla of North Kashmir. Results: This study was conducted prospectively over seven years from March 2011 to February 2017. A total of 802 patients were enrolled in the study. Among them, there were a total of 638 adult patients and 164 paediatric patients with a male: female ratio of 1:0.99. Majority of patients belonged to rural areas of north Kashmir and had received no or elementary education. Pulmonary tuberculosis was diagnosed in 530 (66 %) patients and 272 (34%) patients were diagnosed as extrapulmonary tuberculosis. Sputum for AFB was important mode of diagnosis in our series and was positive in 525 (65%) our patients. Majority of patients presented with fever, weight loss, and night sweats. None of the patients had Acquired Immunodeficiency syndrome (AIDS). There was a consistent improvement in AFB isolation among TB patients over the study period. Majority of our patients were cured completely of disease Conclusion: Sputum positive pulmonary tuberculosis remains the most common presentation of tuberculosis in North Kashmir. There is a steady increase in the proportion of bacteriologically confirmed TB cases over the study period. Furthermore, DOTS treatment is successful in all forms of tuberculosis. JMS 2018;21(1):11-16

scholarly journals Epidemiological Profile and Determinants of Tuberculosis in Urban Nepalese Population

2019 ◽  
Vol 2 (2) ◽  
pp. 250-254
Author(s):  
Subash Bhatta ◽  
Nayana Pant
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Female Ratio ◽  
Short Course ◽  
Increased Risk ◽  
The Family ◽  
Directly Observed Treatment ◽  
History Of ◽  
The Mean ◽  
Epidemiological Profile ◽  
Male To Female

Introduction: Tuberculosis has evolved through ages to remain a major cause of morbidity and mortality worldwide. Despite having a very successful Directly Observed Treatment, Short-course program, tuberculosis is still one of the most widespread infections in Nepal. This study was done to observe the epidemiological profile of tuberculosis patients in an urban Nepalese population.Materials and Methods: 585 newly diagnosed cases of pulmonary and extrapulmonary tuberculosis in two tertiary level hospitals in the country were enrolled in the study during a period of 18months. A standard questionnaire was formatted and the required information was acquired with the help of interview and investigation reports.Results: The mean age of presentation was 35.76 with a male to female ratio of 1.48:1.57% of the cases had less than primary education with 26 % being illiterates. The most commonly involved occupational group was farmers (22%) followed by students (20%) and laborers (14%). 22% of cases had a history of contact with tuberculosis in the family. 41 % were smokers and 18 % abused alcohol. Pulmonary tuberculosis comprised 68% of the total cases. The most common extrapulmonary presentation was lymph node TB (28%) followed by pleural effusion (21.5%) and tubercular meningitis (16%).Conclusions: Young people with lower literacy levels and with a family history of tuberculosis are at increased risk of acquiring tuberculosis and community approaches for tuberculosis control should target this group to reduce the burden of the disease

Comparative assessment of the dynamics of the incidence of pulmonary and etraulmonary tuberculosis in St. Petersburg for half a century of observation

MedAlliance ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 6-14
Keyword(s):  
Control System ◽  
Incidence Rate ◽  
Extrapulmonary Tuberculosis ◽  
High Rate ◽  
Tb Control ◽  
Complete Restoration ◽  
Third Stage ◽  
High Level ◽  
Clinical Awareness ◽  
Positive Effect

This article describes the results of comparative analysis of the dynamics of incidence of pulmonary tuberculo-sis (TBP), extrapulmonary extrarespiratory tuberculo-sis (TBER) and respiratory extrapulmonary tuberculosis (TBREP) in St. Petersburg (Leningrad) from 1970 to 2019. Throughout the 50 years of observation, epidemiological situation for TBP, especially for TBER, hasmuch improved, with incidence of the latter going down 30 times. Five stages (decades) were identified, within which the factors demonstrate practically the same impact, the growth rate of indicators was calculated for each stage (the value of indicators at the beginning of each stage taken as 100%).The first stage was a simultaneous reduction in the inci-dence rate in all categories of TB localization against the background of socio-economic factors positive effect and organization of effective and comprehensive an-ti-TB measures. In the second stage (1980ies, a period of growing socio-economic problems), the positive dynam-ics of TB incidence stopped and switched to stabilization at a low level. Indicators became more volatile, while TB dynamics by localization more and more desynchro-nized. Тhe third stage (1990iеs, a period of social and economic crisis) was char-acterised by a sharp increase of TB incidence, especially TBREP, with a switch to stabi-lization at a high level. The fourth stage (2000 through 2009, the beginning of TB control system restoration) demonstrated the indicators’ dynamics desynchroniza-tion: the incidence of TBP and TBREP has stabilized, and TBER continued to decline. The fifth stage (2009 through 2019, complete restoration of TB control system) showed a steady trend of incidence rate reduction and return of uniformity in incidence rate of various localizations.There is no increase in the proportion of extrapulmonary TB expected for the incidence decline. TBER incidence had been declining in most stages, with the exception of the 90ies, which could be explained by substandard work in identifying patients, and the rarity of TBER etiological verification. It is necessary to raise the clinical awareness of narrow specialists and general practitioners in the di-agnostic problems associated with TBER.The coincidence of the rate of TB incidence decrease in main localizations in the 1970ies and 2010s proves that a comprehensive state strategy to combat tuberculosis can provide a high rate of TB incidence decrease in various social layers with positive social and economic conditions of life of the population.

scholarly journals The Effectiveness of Internal Control and Corporate Social Responsibility: Evidence from Chinese Capital Market

2018 ◽  
Vol 10 (11) ◽  
pp. 4006 ◽  
Author(s):  
Xiao Li ◽  
Chunmei Zheng ◽  
Gang Liu ◽  
Muhammad Sial
Keyword(s):  
Corporate Governance ◽  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Internal Control ◽  
Economic Transition ◽  
Transition Period ◽  
Practical Importance ◽  
Principal Agent ◽  
Positive Role ◽  
Corporate Social

From the perspective of the effectiveness of internal control, according to the Stakeholder Theory, Principal-Agent Theory and Reputation Theory, this paper analyzes comparatively the influences of internal control on the assumption of corporate social responsibility (SCPS) from the accrual basis, and the fulfillment of corporate social responsibility (CSRF) from the cash flow system respectively. Using a sample of 1767 firms listed in China between 2011 and 2016, we find that effective internal control has significantly promoted enterprises to assume social responsibilities. Meanwhile, effective internal control substantially improves the fulfillment of corporate social responsibility. This study overcomes the current situation that the two concepts of assumption and fulfillment of corporate social responsibility have not been distinguished in previous literature. We suggest that, in the economic transition period, the positive role of internal control in corporate governance should be promoted to protect the legitimate rights and interests of stakeholders; the adverse impact of the principal-agent relationship between shareholders and management on corporate governance should be avoided, building high-quality internal control; enterprises achieve steady and sustainable development process by the positive reputation value and robust external monitoring mechanism. This research is of practical importance to strengthen the subsequent construction of the internal control system and the long-term practice of corporate social responsibility.

The Incidence Rate of Lymphadenitis after Bacille Calmette-Guérin (BCG) Vaccination

2016 ◽  
Vol 23 (1) ◽  
pp. 54 ◽  
Author(s):  
Jaehong Kim ◽  
Kyujin Lee ◽  
Jong-Hyun Kim ◽  
Seong Joon Kim ◽  
Soo Young Lee ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Bacille Calmette Guerin ◽  
Bcg Vaccination

scholarly journals Plant Phenology and Its Anthropogenic and Natural Influencing Factors in Densely Populated Areas During the Economic Transition Period of China

2022 ◽  
Vol 9 ◽  
Author(s):  
Peijun Ju ◽  
Wenchao Yan ◽  
Jianliang Liu ◽  
Xinwei Liu ◽  
Liangfeng Liu ◽  
...  
Keyword(s):  
Climate Change ◽  
Economic Transition ◽  
Transition Period ◽  
Growing Season ◽  
Plant Phenology ◽  
Future Research ◽  
Urban Management ◽  
Climate Factors ◽  
Natural Ecosystems ◽  
The Impact

As a sensitive, observable, and comprehensive indicator of climate change, plant phenology has become a vital topic of global change. Studies about plant phenology and its responses to climate change in natural ecosystems have drawn attention to the effects of human activities on phenology in/around urban regions. The key factors and mechanisms of phenological and human factors in the process of urbanization are still unclear. In this study, we analyzed variations in xylophyta phenology in densely populated cities during the fast urbanization period of China (from 1963 to 1988). We assessed the length of the growing season affected by the temperature and precipitation. Temperature increased the length of the growing season in most regions, while precipitation had the opposite effect. Moreover, the plant-growing season is more sensitive to preseason climate factors than to annual average climate factors. The increased population reduced the length of the growing season, while the growing GDP increased the length of the growing season in most regions (8 out of 13). By analyzing the impact of the industry ratio, we found that the correlation between the urban management of emerging cities (e.g., Chongqing, Zhejiang, and Guizhou) and the growing season is more significant, and the impact is substantial. In contrast, urban management in most areas with vigorously developed heavy industry (e.g., Heilongjiang, Liaoning, and Beijing) has a weak and insignificant effect on plant phenology. These results indicate that different urban development patterns can influence urban plant phenology. Our results provide some support and new thoughts for future research on urban plant phenology.

Smartphones can improve adherence rates for TB treatment

BMJ ◽  
2019 ◽  
pp. l4920 ◽  
Author(s):  
Rob Cook ◽  
Tara Lamont ◽  
Rosie Martin
Keyword(s):  
Applied Research ◽  
Research Programme ◽  
Link Type ◽  
Tb Treatment ◽  
Directly Observed Treatment ◽  
Superiority Trial ◽  
Randomised Controlled ◽  
Treatment Observation

The studyStory A, Aldridge R, Smith C, et al. Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial. Lancet 2019;393:1216-24.The study was funded by the NIHR Programme Grants for Applied Research programme (project number RP-PG-0407-10340).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000777/smartphones-for-tb-treatment-observation

scholarly journals Comparison of Led Fluorescent Microscopy and the Gene Xpert MTB/RIF Assay in Diagnosis of Pulmonary and Extrapulmonary Tuberculosis

2019 ◽  
Vol 6 ◽  
pp. 127-132
Author(s):  
Sanam Thapa Magar ◽  
Gokarna Ghimire ◽  
Pradeep Kumar Shah
Keyword(s):  
Pulmonary Tuberculosis ◽  
Extrapulmonary Tuberculosis ◽  
Fluorescent Microscopy ◽  
Cross Sectional Study ◽  
Smear Microscopy ◽  
Cross Sectional ◽  
Female Ratio ◽  
Standard Guideline ◽  
National Tuberculosis ◽  
Male To Female

Objectives: The objective of this study was to evaluate Gene Xpert MTB/RIF Assay and anid fast staining (AFB) for rapid detection of Mycobacterium tuberculosis in specimen of patients suspected of pulmonary tuberculosis (PTB) and extra pulmonary tuberculosis (EPTB). Methods: A comparative cross-sectional study of 400 samples (PTB-365 and EPTB-35) of patients visiting National Tuberculosis Centre (NTC) was conducted from July 2018 to December 2018. Gene Xpert MTB/ RIF Assay, smear microscopy were performed under standard guideline inside biosafety cabinet class II. The result obtained from both the tests were analyzed using SPSS 20.0 software and Excel 2019. Results: Of the total samples, 18% (72/400) and 39% (156/400) were positive by AFB smear microscopy and Xpert MTB/RIF assay respectively. Prevalence of MTB positive was highest in the age group 35-44 years, 33 cases (17.74%) were detected in total, with a male to female ratio of 2.3:1. Pleural fluid, pus, and CSF fluid also yielded positive results with the Gene Xpert MTB/RIF assay accounting 1.28%, 0.64% and 1.28% of MTB positive case respectively. Rifampicin resistance was observed in 1.28% of the cases. Conclusion: The key findings of this study suggest that Gene Xpert test should be implemented as primary diagnostic test for PTB and EPTB.

scholarly journals Task-shifting directly observed treatment and multidrug-resistant tuberculosis injection administration to lay health workers: stakeholder perceptions in rural Eswatini

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ernest Peresu ◽  
J. Christo Heunis ◽  
N. Gladys Kigozi ◽  
Diana De Graeve
Keyword(s):  
Healthcare Workers ◽  
Health Workers ◽  
Multidrug Resistant ◽  
Task Shifting ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Key Stakeholders ◽  
Mdr Tb ◽  
Directly Observed Treatment

Abstract Background Eswatini is facing a critical shortage of human resources for health (HRH) and limited access to multidrug-resistant tuberculosis (MDR-TB) treatment in rural areas. This study assessed multiple stakeholders’ perceptions of task-shifting directly observed treatment (DOT) supervision and administration of intramuscular MDR-TB injections to lay health workers (LHWs). Methods A mixed methods study comprising a cross-sectional survey using a semi-structured questionnaire with community treatment supporters (CTSs) and a focus group discussion with key stakeholders including representatives from the Eswatini Ministry of Health (MOH), donor organisations, professional regulatory institutions, nursing academia, civil society and healthcare providers was conducted in May 2017. Descriptive statistics, thematic content analysis and data triangulation aided in the interpretation of results. Results A large majority of CTSs (n = 78; 95.1%) were female and 33 (40.2%) were older than 50 years. Most (n = 7; 70.0%) key stakeholders had over 10 years of work experience in policy-making, advocacy in the fields of HRH or day-to-day practice in MDR-TB management. Task-shifting of MDR-TB injection administration was implemented without national policy guidance and regulation. Stakeholders viewed the strategy to be driven by the prevailing shortage of professional frontline HRH and limited access to MDR-TB treatment. Task-shifting was perceived to improve medication adherence, and reduce stigma and transport-related MDR-TB treatment access barriers. Frontline healthcare workers and implementing donor partners fully supported task-shifting. Policy-makers and other stakeholders accepted task-shifting conditionally due to fears of poor standards of care related to perceived incompetence of CTSs. Appropriate compensation, adequate training and supervision, and non-financial incentives were suggested to retain CTSs. A holistic task-shifting policy and collaboration between the MOH, academia and nursing council in regulating the practice were recommended. Conclusions Stakeholders generally accepted the delegation of DOT supervision and administration of intramuscular MDR-TB injections to LHWs as a strategy to increase access to treatment, albeit with some apprehension. Findings from this study stress that task-shifting is not a panacea for HRH shortages, but a short-term solution that must form part of an overall simultaneous strategy to train, attract and retain adequate numbers of professional healthcare workers in Eswatini. To address some of the apprehension and ambivalence about expanding access to MDR-TB services through task-shifting, attention should be paid to important aspects such as competence-based training, certification and accreditation, adequate supportive on-the-job supervision, recognition, compensation, and expediting policy and regulatory support for LHWs.

scholarly journals BCG vaccination following latent TB treatment: Possible implications for different settings

2019 ◽  
Vol 80 ◽  
pp. S17-S19 ◽  
Author(s):  
L. Goscé ◽  
J. Bitencourt ◽  
R.K. Gupta ◽  
S. Arruda ◽  
L.C. Rodrigues ◽  
...  
Keyword(s):  
Bcg Vaccination ◽  
Tb Treatment ◽  
Latent Tb
Sign in / Sign up

Export Citation Format

Share Document