scholarly journals Surgical treatment of unicentric plasma cell histological type Castleman's disease

2011 ◽  
Vol 68 (9) ◽  
pp. 795-799 ◽  
Author(s):  
Nebojsa Maric ◽  
Vojkan Stanic ◽  
Vlado Cvijanovic ◽  
Aleksandar Ristanovic ◽  
Snezana Kovacevic ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Lymph Nodes ◽  
Plasma Cell ◽  
Histological Type ◽  
Cell Type ◽  
Mixed Cell ◽  
Vena Cava Superior ◽  
Plasma Cell Type ◽  
Therapy Effect

Introduction. Castleman?s disease or angiofollicular lymph hyperplasia is a rare disease with two identified clinical forms. Unicentric or localized form is characterized by isolated growth of lymph nodes, most often in mediastinum, and multicentric form is expressed as systemic disease with spread lymphadenopathy, organomegaly and presence of general symptoms of the disease. Histological types are hyalovascular, plasma-cell and transitive (mixed) cell. Case report. This case report shows a woman, 59 years old, with unicentric form of plasma-cell type of Castleman?s disease. Unicentric form is usually shown as hyalovascular histological type, extremely rare as plasma-cell type, and transitive (mixed) cell type was never described in literature as localized clinical form. The disease was manifested with chest pain, loss of body weight, exhaustion and weakness of legs. Further diagnostic procedures found the presence of enlarged lymph nodes paratracheally right, in a close contact with vena cava superior. The disease was confirmed by histopathological analysis of bioptated mediastinal lymph node after mediastinoscopy. Surgical treatment included extirpation of enlarged lymph nodes. After the regular postoperative condition, a full therapy effect was confirmed. Conclusion. Unicentric form of Castleman?s disease is expressed with enlarged lymph nodes on predilected places, usually in mediastinum. Surgical treatment is best method for the management of the disease and brings a full recovery of patient.

scholarly journals Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

2018 ◽  
Vol 17 (5) ◽  
pp. 0-10
Author(s):  
Claudio De Vito ◽  
Thomas Papathomas G. ◽  
Federica Pedica ◽  
Pauline Kane ◽  
Ali Amir ◽  
...  
Keyword(s):  
Case Report ◽  
Ct Scan ◽  
Histological Examination ◽  
Plasma Cell ◽  
Hepatocellular Adenoma ◽  
Castleman Disease ◽  
Cell Type ◽  
Aa Amyloidosis ◽  
Plasma Cell Type ◽  
Systemic Symptoms

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

scholarly journals Abdominal localization of unicentric form of Castleman disease: A case report

2017 ◽  
Vol 74 (4) ◽  
pp. 367-370
Author(s):  
Bosko Milev ◽  
Borka Milev ◽  
Zoran Kostic ◽  
Darko Mirkovic ◽  
Nenad Perisic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Mr Enterography ◽  
Unknown Etiology ◽  
Cell Type ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Golden Standard

Introduction. Castleman disease is a rare disease of the unknown etiology, occuring in two clinical forms: unicentric or multicentric. It is characterized by the hyperplasia of lymph glands. In literature the four pathohistological forms were described: hyaline vascular type, plasma cell type, mixed type and a recently recognized plasmablastic type. The most frequent changes are localized in the mediastinum, while the abdominal localization is with significatly rare occurrence, and that was the motive for presentation of this case. Case report. In a 41-year old male magnetic resonance (MR) enterography showed a change in the ileocecal area without the presence of subjective symptoms of digestive tract and without loss of body mass. Due to the suspicion of stromal tumor, surgical intervention was indicated. Pathohistological findings showed Castleman lymphadenopathia reactiva mesenterii (plasma cell type) which was in the unicentric form. There were present only anaemia and the increased value of sedimentation from the laboratory analyses. Conclusion. Abdominal localization of unicentric plasma cell form occurs rarely and the surgical method of treatment presents the golden standard as it was shown in the presented case.

A Case of Resected Plasma Cell Type Castleman’s Disease with Intramediastinal Lymph Nodes Spread

2014 ◽  
Vol 20 (Supplement) ◽  
pp. 682-685 ◽  
Author(s):  
Masaya Aoki ◽  
Tsunayuki Otsuka ◽  
Masakazu Yanagi ◽  
Naoya Yokomakura ◽  
Toshiyuki Nagata ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Plasma Cell ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Cell Type ◽  
Plasma Cell Type

scholarly journals Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease

2020 ◽  
Vol 60 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Yanyan Han ◽  
Takuro Igawa ◽  
Kyohei Ogino ◽  
Asami Nishikori ◽  
Yuka Gion ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Cell Type ◽  
Hemosiderin Deposition ◽  
Plasma Cell Type

scholarly journals Transitional type of Castleman's disease manifested as the POEMS syndrome

2004 ◽  
Vol 61 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Ilija Tomic ◽  
Goran Plavec ◽  
Olga Tasic ◽  
Aleksandar Ristanovic ◽  
Vlado Cvijanovic
Keyword(s):  
Lymph Nodes ◽  
Mediastinal Lymph Node ◽  
Poems Syndrome ◽  
Mediastinal Lymphadenopathy ◽  
Cell Type ◽  
Mixed Cell ◽  
Vascular Type ◽  
Disease Case ◽  
Transitional Type ◽  
Angiofollicular Hyperplasia

Background. Castleman?s disease is an atypical lymphoproliferative disorder characterized by angiofollicular hyperplasia of lymph nodes. Histologically it can be classified into a hyaline-vascular type, plasma-cell type, and transitional (mixed-cell) type, while clinically localized type has been classified as unicentric, or generalized (multicentric) form of the disease. Case report. This paper presents a 21 years old male patient with multicentric Castleman?s disease, a transitional (mixed-cell) type. The disease was manifested by fever, generalized enlargement of peripherial lymph nodes, breast glands enlargement, hyperemia of the face, and weakness of the lower extremities. We found mediastinal lymphadenopathy, pleural and pericardial effusions, sensorimotor peripherial neuropathy and polyclonal hypergammaglobulinemia. The simultaneous presence of these manifestations of the disease (sensomotor peripheral neuropathy, lymphadenopathy, effusions endocrinopathy, polyclonal gammaglobulinemia and skin changes) is indentified as POEMS syndrome. The diagnosis of Castleman?s disease was based on the results of histopathologic analysis of mediastinal lymph node biopsies after thoracotomy. The patient was treated with corticosteroids (prednisone 80 mg daily for 2 weeks followed by 60 mg daily). A partial response was achieved after 4 months of treatment. Conclusion. A transitional type of multicentric Castleman?s disease may be present itself as POEMS syndrome. The effect of corticosteroid therapy in this form of the disease is unpredictable.

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