scholarly journals Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease

2020 ◽  
Vol 60 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Yanyan Han ◽  
Takuro Igawa ◽  
Kyohei Ogino ◽  
Asami Nishikori ◽  
Yuka Gion ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Cell Type ◽  
Hemosiderin Deposition ◽  
Plasma Cell Type

scholarly journals Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

2018 ◽  
Vol 17 (5) ◽  
pp. 0-10
Author(s):  
Claudio De Vito ◽  
Thomas Papathomas G. ◽  
Federica Pedica ◽  
Pauline Kane ◽  
Ali Amir ◽  
...  
Keyword(s):  
Case Report ◽  
Ct Scan ◽  
Histological Examination ◽  
Plasma Cell ◽  
Hepatocellular Adenoma ◽  
Castleman Disease ◽  
Cell Type ◽  
Aa Amyloidosis ◽  
Plasma Cell Type ◽  
Systemic Symptoms

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

scholarly journals Abdominal localization of unicentric form of Castleman disease: A case report

2017 ◽  
Vol 74 (4) ◽  
pp. 367-370
Author(s):  
Bosko Milev ◽  
Borka Milev ◽  
Zoran Kostic ◽  
Darko Mirkovic ◽  
Nenad Perisic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Mr Enterography ◽  
Unknown Etiology ◽  
Cell Type ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Golden Standard

Introduction. Castleman disease is a rare disease of the unknown etiology, occuring in two clinical forms: unicentric or multicentric. It is characterized by the hyperplasia of lymph glands. In literature the four pathohistological forms were described: hyaline vascular type, plasma cell type, mixed type and a recently recognized plasmablastic type. The most frequent changes are localized in the mediastinum, while the abdominal localization is with significatly rare occurrence, and that was the motive for presentation of this case. Case report. In a 41-year old male magnetic resonance (MR) enterography showed a change in the ileocecal area without the presence of subjective symptoms of digestive tract and without loss of body mass. Due to the suspicion of stromal tumor, surgical intervention was indicated. Pathohistological findings showed Castleman lymphadenopathia reactiva mesenterii (plasma cell type) which was in the unicentric form. There were present only anaemia and the increased value of sedimentation from the laboratory analyses. Conclusion. Abdominal localization of unicentric plasma cell form occurs rarely and the surgical method of treatment presents the golden standard as it was shown in the presented case.

Fine needle aspiration cytology of Castleman disease, plasma cell type. A report of three cases

2014 ◽  
Vol 47 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Carlos Humberto Gordillo Vélez ◽  
Israel Bernal Becerra ◽  
Carmen Bárcena García ◽  
Federico Álvarez Rodríguez ◽  
José Antonio Jiménez Heffernan
Keyword(s):  
Plasma Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Castleman Disease ◽  
Cell Type ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Plasma Cell Type ◽  
Needle Aspiration Cytology

scholarly journals An Adolescent Case of Castleman Disease of the Plasma Cell Type Treated with Radiotherapy

2014 ◽  
Vol 21 (2) ◽  
pp. 157-162
Author(s):  
Tae Hoon Heo ◽  
Hyun Wook Lim ◽  
Ji Hyun Sim ◽  
Jung Hwa Lee ◽  
Eun Hee Lee ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Castleman Disease ◽  
Cell Type ◽  
Plasma Cell Type

scholarly journals HHV-8–encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice

Blood ◽  
2012 ◽  
Vol 119 (22) ◽  
pp. 5173-5181 ◽  
Author(s):  
Jan Suthaus ◽  
Christiane Stuhlmann-Laeisz ◽  
Van S. Tompkins ◽  
Timothy R. Rosean ◽  
Wolfram Klapper ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Castleman Disease ◽  
The Body ◽  
Cell Type ◽  
Human Herpes Virus 8 ◽  
Multicentric Castleman Disease ◽  
Plasma Cell Type ◽  
Herpès Virus

Human herpes virus 8 (HHV-8) or Kaposi sarcoma-associated herpes virus is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and plasma cell-type multicentric Castleman disease (MCD). HHV-8 encodes a viral homolog of human IL-6, called viral IL-6 (vIL-6), which does not require the cellular IL-6 receptor for binding to the ubiquitously expressed gp130 receptor subunit and subsequent JAK-STAT signaling. Thus, in contrast to IL-6, vIL-6 can stimulate virtually all cells in the body. To elucidate the mechanism by which vIL-6 drives human diseases, we generated transgenic mice that constitutively express vIL-6 under control of the MHC class I promoter. The mice were found to exhibit vIL-6 serum levels comparable with those observed in HHV-8–infected patients, to contain elevated amounts of phosphorylated STAT3 in spleen and lymph nodes, where vIL-6 was produced, and to spontaneously develop key features of human plasma cell-type MCD, including splenomegaly, multifocal lymphadenopathy, hypergammaglobulin-emia, and plasmacytosis. Transfer of the vIL-6 transgene onto an IL-6–deficient genetic background abrogated MCD-like phenotypes, indicating that endogenous mouse IL-6 is a crucial cofactor in the natural history of the disease. Our results in mice suggest that human IL-6 plays an important role in the pathogenesis of HHV-8–associated MCD.

Multicentric Plasma Cell Type of Castleman Disease in a Child

2013 ◽  
Vol 35 (7) ◽  
pp. e306-e308 ◽  
Author(s):  
Tuba H. Karapinar ◽  
Özlem Tüfekçi ◽  
Salih Gözmen ◽  
Şebnem Yilmaz ◽  
Gülersu İrken ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Castleman Disease ◽  
Cell Type ◽  
Plasma Cell Type

scholarly journals Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

2019 ◽  
Vol 58 (17) ◽  
pp. 2555-2560 ◽  
Author(s):  
Shino Fujimoto ◽  
Tomoyuki Sakai ◽  
Hiroshi Kawabata ◽  
Nozomu Kurose ◽  
Sohsuke Yamada ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Systemic Inflammation ◽  
Castleman Disease ◽  
Cell Type ◽  
Histological Features ◽  
Plasma Cell Type

A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features

2017 ◽  
Vol 213 (11) ◽  
pp. 1378-1383 ◽  
Author(s):  
Takuro Igawa ◽  
Rika Omote ◽  
Hiaki Sato ◽  
Kohei Taniguchi ◽  
Katsuya Miyatani ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
Castleman Disease ◽  
Cell Type ◽  
Morphological Variant ◽  
Plasma Cell Type ◽  
Mantle Cell
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