scholarly journals Influence of hemoglobin level and dose of administered recombinant human beta erythropoietin on survival of hemodialysis patients

2011 ◽  
Vol 68 (9) ◽  
pp. 749-755
Author(s):  
Violeta Knezevic ◽  
Aleksandra Milosevic ◽  
Slavenka Vodopivec ◽  
Dusan Bozic ◽  
Ivana Budosan ◽  
...  
Keyword(s):  
Function Analysis ◽  
Underlying Disease ◽  
Hemodialysis Patients ◽  
Hemoglobin Level ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Dialysis Duration ◽  
Significant Difference ◽  
The Difference ◽  
Stage Renal Disease

Background/Aim. In patients with end-stage renal disease, treatment with erythropoietin lowers cardiovascular morbidity, improves quality of life and patient survival. The aim of this study was to determine the difference in survival of hemodialysis patients treated with recombinant human beta erythropoietin and patients without this treatment, and to determine the influence of hemoglobin level and erythropoietin dose on the survival of these patients. Method. The study included 291 patients undergoing maintenance hemodialysis, 122 were on erythropoietin therapy, 169 patients formed control group. The study was performed at the Clinic for Nephrology and Clinical Immunology, Clinical Center of Vojvodina, during a 69-month period. We analyzed basic demographic parameters, dialysis duration, underlying disease, comorbidities, death causes, bloodwork parameters and erythropoietin dosage. Descriptive statistics, Anova, Manova, discriminant function analysis, Cox regressional model and Kaplan Meier survival curves were used as statistical methods. Results. Average age and dialysis duration in the experimental group were 47.88 ? 13.32 years, and 45.76 ? 46.73 months, respectively and in the control group 58.73 ? 12.67 years and 62.80 ? 55.23 months, respectively. Average level of hemoglobin and hematocrit in the group in which erythropoietin had been administered was 11.40 ? 8.39 g/dL and 0.35 ? 0.04/L, while the control group these values were 8.52 ? 7.73 g/dL and 0.26 ? 0.04/L, respectively. Average monthly dosage of erythropoietin was 21 587 ? 10 183.36 IJ/month. Significant difference in survival was determined (p < 0,05) between the stated patient groups. A significant difference (p < 0,05) was found in survival of the patients in which erythropoietin was administered regarding hemoglobin level (< 100 g/L/100-110 g/L/110-120 g/L/ > 120 g/L), as well as in regard of erythropoietin dose applied (< 20 000 IJ/20 000-40 000 IJ/ > 40 000 IJ/month). Conclusion. Best survival was noted in patients with hemoglobin > 120 g/L and erythropoietin dose < 20 000 IJ/month.

scholarly journals Effects of Arterial Needle Placement in Arteriovenous Fistula on Dialysis Adequacy of End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis

2016 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Blood Flow ◽  
Arteriovenous Fistula ◽  
Intervention Group ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Needle Placement ◽  
Dialysis Adequacy ◽  
Significant Difference ◽  
Stage Renal Disease ◽  
End Stage

Objective: The arterial needle placement in arteriovenous fistula (AVF) can either be antegrade (in the direction of blood flow or pointing towards the heart) or retrograde (against the direction of blood flow) while venous needle placement should always be in the same direction as the blood flow. This study determined the effects of arterial needle placement in the arteriovenous fistula on dialysis adequacy of End-Stage Renal Disease (ESRD) patients undergoing maintenance hemodialysis in United Candelaria Doctors Hospital - Nephro Synergies Inc. (UCDHNSI) Hemodialysis Center. Methods: A randomized controlled trial design was used in the study. A total of 20 non-diabetic, non-cardiac patients on maintenance hemodialysis for more than 6 months were randomized either to the intervention group (patients’ AVF were cannulated in a retrograde manner) or the control group (patients’ AVF were cannulated in an antegrade manner). Urea reduction ratio (URR) and Kt/V as well as access recirculation percentage were used to determine dialysis adequacy. Pre-dialysis, in the first 30 minutes of dialysis initiation and post-dialysis blood samples were obtained in each patient in 6 succeeding hemodialysis considering dialyzer reuse up to fifth reuse. Means were compared by independent t-test. Results: The findings of the study revealed that the mean URR and Kt/V of the subjects cannulated in retrograde manner and antegrade manner were 69.35% and 1.45, and 74.65% and 1.70, respectively. The mean access recirculation percentage of the subjects was 4.65% in the intervention group and 3.02% in the control group. There was a significant difference on URR and Kt/V of the subjects using retrograde and antegrade arterial needle placement in 6 succeeding hemodialysis sessions. There was no significant difference on access recirculation percentage of the subjects using retrograde and antegrade arterial needle placement in 6 succeeding hemodialysis sessions. Conclusions: Antegrade arterial needle placement provides more adequate hemodialysis than retrograde arterial needle placement in terms of URR and Kt/V values among non-diabetic, non-cardiac patients undergoing maintenance hemodialysis in 6 succeeding hemodialysis sessions. The directions of the arterial needle either retrograde and antegrade did not have significant effects on access recirculation.

Comparing the effects of cold compress and Xyla-p cream on hemodynamic changes in hemodialysis patients during venipuncture

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Ziba Ghoreyshi ◽  
Monireh Amerian ◽  
Farzaneh Amanpour ◽  
Reza Mohammadpourhodki ◽  
Hossein Ebrahimi
Keyword(s):  
Blood Pressure ◽  
Physiological State ◽  
Vital Signs ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Intermittent Hemodialysis ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
The Difference

AbstractBackgroundThe vital signs reflect the physiological state of patients in various clinical conditions. The purpose of this study was to compare the effects of cold compress and Xyla-P cream on hemodynamical changes during venipuncture in hemodialysis patients.Methods and MaterialIn this clinical trial study, 50 patients under hemodialysis were selected by simple random sampling. The patients were then randomly assigned to either Xyla-P cream, cold compress or placebo groups. The vital signs (blood pressure and pulse) were measured upon two intermittent hemodialysis sessions before and after venipuncture. Data were analyzed using repeated measures analysis of variance.ResultsThe mean alternation in systolic blood pressure was significantly different comparing the placebo and cold compress groups before and after intervention (p<0.001). However, the difference was not significant between the Xyla-P cream group and either placebo (p=0.402) or ice compress (p=0.698) groups. The difference of the mean diastolic blood pressure was significant comparing the placebo group with either the Xyla-P cream group (p=0.003) or cold compress group (p<0.001) before and after intervention. In addition, there was a significant difference in the mean number of heartbeats comparing the control group with either the Xyla-P cream group (p<0.001) or cold compress group (p<0.001) before and after the intervention.ConclusionsConsidering the beneficial effects of ice compress and the Xyla-P cream on reduction of cardiovascular parameters, it is recommended to use these methods in hemodialysis patients during venipuncture.

scholarly journals Risk of Hepatitis B and Hepatitis C Among Whole Blood Transfused Chronic Hemodialysed Chronic Kidney Disease (CKD) Patients

2019 ◽  
Vol 30 (2) ◽  
pp. 78-82
Author(s):  
Md Abdul Quader ◽  
Khan Anisul Islam ◽  
Tashmim Farhana Dipta ◽  
Md Ashadul Islam
Keyword(s):  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Transmitted Infection ◽  
Transfusion Transmitted Infection ◽  
Healthy Donors ◽  
Significant Difference

Background: Patients with chronic renal failure on maintenance hemodialysis (MHD) have high risks of viral infections and the prevalence of transfusion transmissible viral infection is common among them. The aim of our study was to detect hepatitis B and hepatitis C virus in hemodialysis patients and healthy donors and to explore if there was a relationship between duration of hemodialysis and hepatitis B and hepatitis C in our patients. Methodology: A cross sectional study was conducted in a private hemodialysis clinic in Dhaka city with end stage renal disease on maintenance hemodialysis and an age matched healthy donors as comparable group from July 2015 to June 2016. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), HBsAg and anti HCV were determined along with duration and units of blood transfusion needed by them. Results: Our study showed the mean age of 126 MHD patients were 42.2±11.7 years along with 132 healthy donors as control group had mean age 39.2±9.7 years. Among the hemodialysis patients 34 (26.98%) showed transfusion transmitted infection positivity and in control group 11 (8.33%) showed transfusion transmitted infection positivity with the difference between two study group showed statistical significance (p<o.oo1). History of blood transfusion showed the significant predictor of occurrence of TTV infection in hemodialysis patients (p<0.01). Duration of hemodialysis and seropositivity of TTI was not significant (p>0.05). The number of units of blood transfusion and the TTI positivity also showed no significant difference (p>0.05) with HBsAg (17.46%) and anti HCV (9.52%). Conclusions: The prevalence of TTI in hemodialysis patients is significantly higher than that in healthy individuals. So, the regular screening of HBV and HCV among patients and healthy donors are strictly provided to monitor the communicable disease. Bangladesh J Medicine July 2019; 30(2) : 78-82

scholarly journals Levocarnitine Injections Decrease the Need for Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia

2017 ◽  
Vol 7 (3) ◽  
pp. 188-197 ◽  
Author(s):  
Takashi Maruyama ◽  
Terumi Higuchi ◽  
Toshio Yamazaki ◽  
Erina Okawa ◽  
Hideyuki Ando ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Renal Anemia ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Human Erythropoietin ◽  
Significant Difference ◽  
Group 2 ◽  
To Receive ◽  
Esa Therapy

Aims: The aim of this study was to evaluate the efficacy of levocarnitine injection for renal anemia in hemodialysis patients. Methods: In this randomized controlled clinical trial, we randomly assigned patients on maintenance hemodialysis at our hospital to receive levocarnitine injections (n = 30) or no injection (n = 30) and monitored the patients during 12 months of treatment. In the treatment group, patients received an injection of levocarnitine 1,000 mg 3 times weekly after hemodialysis sessions. All patients received recombinant human erythropoietin as an erythropoiesis-stimulating agent (ESA). Response to ESA therapy was determined by calculating the erythropoietin responsiveness index (ERI; ESA dose·kg-1·g-1· dL-1·week-1). Results: (1) The target levels of hemoglobin and hematocrit were maintained during the study period in both the levocarnitine group and the control group. (2) The dose of ESAs required to maintain these levels decreased gradually in the levocarnitine group and was significantly lower at 6 and 12 months than at study initiation. Furthermore, the dose of ESAs was significantly lower than that in the control group at 12 months. (3) The ERI showed a significant decrease at 6 and 12 months in the levocarnitine group, with a significant difference between the 2 groups at 12 months. Conclusion: Our results suggest that levocarnitine administration can reduce the dose of ESAs required in patients with renal anemia on hemodialysis and improve the response to ESA therapy.

scholarly journals Effect of lavender aromatherapy on well-being among hemodialysis patients: A randomized clinical trial

2018 ◽  
Author(s):  
Masoumeh Bagheri Nesami ◽  
Seyed Afshin Shorofi ◽  
Attieh Nikkhah ◽  
Hossein Roohi Moghaddam ◽  
Ali Mahdavi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Well Being ◽  
Underlying Disease ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group

  In spite of the improvement of dialysis techniques, hemodialysis patients still experience debilitation. Impaired functioning, well-being, and quality of life are among the factors that are of a great concern in these patients. The current study aimed to examine the effects of lavender essential oil on well-being among hemodialysis patients. This randomized clinical trial was conducted on 30 hemodialysis patients. For each patient in the experimental group, five cotton balls were prepared using two drops of lavender essence diluted with sweet almond oil. Lavender was used at five concentrations of 10%, 20%, 30%, 40%, and 50%, administered through pinning the soaked cotton ball on the patients' collar on the first, second, third, fourth, and fifth weeks of the intervention, respectively. The patients were asked to breathe normally for 20 min. On the other hand, the control group received only routine nursing care. The perceived sense of well-being was measured in both groups at the end of each week using a visual analog scale. The mean ages of patients were obtained as 58.9 ± 14.31 and 53.03 ± 15.84 years for the experimental and control groups, respectively. Hypertension was reported to be the most common underlying disease in both groups. The results showed a significant difference in the mean level of well-being in the experimental group in the fourth and fifth weeks of the intervention, compared to that before the intervention. Inhalation aromatherapy with 40% and 50% lavender essence had a positive effect on the perceived sense of well-being in hemodialysis patients. However, lower concentrations of 10%, 20%, and 30% did not exert a comparable effect.

scholarly journals Intervention Effect of Sequential Blood Purification on Early Morning Hypertension in Hemodialysis Patients

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Jibo Li ◽  
Peiqin Jiang ◽  
Gang Wang
Keyword(s):  
Blood Pressure ◽  
Early Morning ◽  
Hemodialysis Patients ◽  
Blood Purification ◽  
Control Group ◽  
Observation Group ◽  
Significant Difference ◽  
Morning Blood Pressure ◽  
The Difference ◽  
Morning Hypertension

Objective: To investigate the effect of sequential blood purification on early morning hypertension in hemodialysis patients. Methods: A total of 76 hemodialysis patients who were admitted in the University of Chinese Academy of Sciences Shenzhen Hospital from June 2017 to August 2019 were selected and recruited in the present study. These patients were randomly divided into two groups, namely the control group and observation group. Each group consisted of 38 patients. The patients in the control group were treated with hemodialysis, while the patients in the observation group were treated with sequential blood purification. Early morning blood pressure was compared between the control group and observation group after 12 weeks of treatment. Results: There was no significant difference in blood pressure between the two groups of patients before treatment (P > 0.05), whereas the blood pressure in the observation group was lower than that in the control group after the treatment, and the difference was statistically significant (P < 0.05). Conclusion: The use of sequential blood purification treatment for hemodialysis patients can significantly reduce the blood pressure in the morning and is worthy of clinical use.

scholarly journals Slower Progression of Arteriosclerosis in Maintenance Hemodialysis Patients with Menaquinone Supplementation: A Perspective Randomized, Placebo-Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 78-78
Author(s):  
Jing Tan ◽  
Dan Xu ◽  
Anxiu Yang ◽  
Ruijun Ren
Keyword(s):  
Controlled Trial ◽  
Hemodialysis Patients ◽  
Vitamin K2 ◽  
Matrix Gla Protein ◽  
Maintenance Hemodialysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Clinical Trial Registry ◽  
Significant Difference ◽  
Maintenance Hemodialysis Patients

Abstract Objectives To investigate the effects of menaquinone on the progression of arteriosclerosis in maintenance hemodialysis patients, and to provide evidence for the clinical prevention strategy of cardiovascular diseases in maintenance hemodialysis patients. Methods In this perspective, randomized, placebo-controlled trial, 107 MHD patients were randomized into Vitamin K2 group (VK2, n = 60) that received vitamin K2(menaquinone) at a dose of 270 μg/d and control group (n = 47). The following measurements were taken at baseline and after 9 months: carotid pulse wave velocity (cPWV) was measured with ultrasound, dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP) was tested with enzyme-linked immunosorbent assay. Results After 9 months follow-up, 40 patients from the VK2 group and 38 patients from the control group were included in the analysis. The cPWV values of MHD patients was positively correlated with age (r = 0.293, P = 0.01) and hypertension complication (r = 0.495, P = 0.00). The baseline cPWV values of VK2 group and the control group did not show a significant difference (7.53 ± 1.47 vs. 7.28 ± 1.18 m/s, P = 0.24). After 9 months of intervention, cPWV values in VK2 group were lower than baseline, but not significant (7.60 ± 1.50 vs. 7.53 ± 1.47 m/s, P = 0.90). The cPWV values of the control group at 6 months were increased when compared with the baseline (7.21 ± 1.18 vs. 7.86 ± 1.14 m/s, P = 0.04) . The increment rate of cPWV(△cPWV) from VK2 group was significantly lower than the control group (1.32 ± 12.53% vs 10.40 ± 16.85%, P = 0.00) 3. Baseline dp-ucMGP level of VK2 group and the control group showed no significant difference (1802.30 ± 552.88 vs. 1698.15 ± 488.06 nmol/L, P = 0.67) . After 9 months, the dp-ucMGP level in VK2 group was significantly decreased (1802.30 ± 552.88 vs 1448.42 ± 456.08 nmol/L, P = 0.01) , and significantly lower than control group (1448.42 ± 456.08 vs 1705.42 ± 424.48 nmol/L, P = 0.03). Conclusions Menaquinone supplementation induced a marked reduction of inactive MGP, and may retard the progression of arteriosclerosis in maintenance hemodialysis patients. This trial was registered at the Chinese Clinical Trial Registry as ChiCTR1900028459. Funding Sources None.

scholarly journals Betroot (Beta vulgaris) administration to anemic pregnant women for increasing hemoglobin level

2020 ◽  
Vol 28 (3) ◽  
pp. 109
Author(s):  
Rr Catur Leny Wulandari ◽  
Is Susiloningtyas
Keyword(s):  
Pregnant Women ◽  
Total Sample ◽  
Hemoglobin Level ◽  
Wilcoxon Test ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
The Difference ◽  
And Control

Objective: To identify the effectiveness of beet juice administration on hemoglobin level of anemic pregnant women.Materials and Methods: This was an experimental quantitative study using pretest-posttest design with a total sample of 30 patients who were divided into 2 groups of treatment groups (beetroot + Fe) and control group (Fe). The treatment was carried out for 14 days. Before and after the treatment, the samples were subjected to hemoglobin examination. Data in this study were the difference between pre-test and post-test values, the results of normality test with Shapiro Wilk, and, to identify the difference between pre-test and post-test, the results of Wilcoxon Test for abnormal data and Paired T-Test for normal data.Results: Mann Whitney Test results between treatment and control groups revealed p (0.023) < alpha (0.05). There was a significant difference in hemoglobin levels between TM III pregnant women with anemia receiving beets and those receiving Fe tablets only.Conclusion: Minimum Hb increase before and after the administration of Fe and beetroot juice to pregnant women was 17.7 gr% and the maximum Hb level was 0.8 gr%.

Serum Thiamine Values in End-Stage Renal Disease Patients under Maintenance Hemodialysis

2015 ◽  
Vol 85 (5-6) ◽  
pp. 348-355 ◽  
Author(s):  
Masamitsu Ubukata ◽  
Nobuyuki Amemiya ◽  
Kosaku Nitta ◽  
Takashi Takei
Keyword(s):  
Thiamine Deficiency ◽  
Risk Index ◽  
Nutritional Risk ◽  
Maintenance Hemodialysis ◽  
Dialysis Patients ◽  
Significant Difference ◽  
Nutritional Risk Index ◽  
Serum Aspartate Aminotransferase ◽  
Stage Renal Disease ◽  
End Stage

Abstract. Objective: Hemodialysis patients are prone to malnutrition because of diet or many uremic complications. The objective of this study is to determine whether thiamine deficiency is associated with regular dialysis patients. Methods: To determine whether thiamine deficiency is associated with regular dialysis patients, we measured thiamine in 100 patients undergoing consecutive dialysis. Results: Average thiamine levels were not low in both pre-hemodialysis (50.1 ± 75.9 ng/mL; normal range 24 - 66 ng/mL) and post-hemodialysis (56.4 ± 61.7 ng/mL). In 18 patients, post-hemodialysis levels of thiamine were lower than pre-hemodialysis levels. We divided the patients into two groups, the decrease (Δthiamine/pre thiamine < 0; - 0.13 ± 0.11) group (n = 18) and the increase (Δthiamine/pre thiamine> 0; 0.32 ± 0.21)) group (n = 82). However, there was no significance between the two groups in Kt/V or type of dialyzer. Patients were dichotomized according to median serum thiamine level in pre-hemodialysis into a high-thiamine group (≥ 35.5 ng/mL) and a low-thiamine group (< 35.4 ng/mL), and clinical characteristics were compared between the two groups. The low-thiamine value group (< 35.4 ng/ml; 26.8 ± 5.3 ng/ml) exhibited lower levels of serum aspartate aminotransferase and alanine aminotransferase than the high-thiamine value group (≥ 35.4 ng/ml; 73.5 ± 102.5 ng/ml) although there was no significance in nutritional marker, Alb, geriatric nutritional risk index , protein catabolic rate and creatinine generation rate. Conclusion: In our regular dialysis patients, excluding a few patients, we did not recognize thiamine deficiency and no significant difference in thiamine value between pre and post hemodialysis.

scholarly journals QOLP-17. GROUP MEDICAL PLAY EFFECTIVELY IMPROVES HOSPITALIZATIONADAPTABILITY OF PEDIATRIC PATIENTS WITH NEUROTUMOR

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii178-ii178
Author(s):  
Xing Zhang ◽  
Fuqiang Zhang ◽  
Mingyao Lai ◽  
Juan Li ◽  
Yangqiong Zhang ◽  
...  
Keyword(s):  
Social Status ◽  
Pediatric Patients ◽  
Picture Book ◽  
Family Satisfaction ◽  
Control Group ◽  
Play Intervention ◽  
Significant Difference ◽  
The Difference ◽  
Therapeutic Play ◽  
Experimental Group

Abstract OBJECTIVE To explore the effect of group medical games on the hospitalization adaptability of pediatric patients with neuro tumor. METHODS pediatric patients with neuro tumor (age:6 to 13 years) who were treated in hospital from June to December 2019 and were hospitalized for 1 month to 2 months. 29 pediatric patients(mean age:9y) were selected as the control group and treated as usual; 26 pediatric patients(meanage:8y) were selected as the experimental group for group therapeutic play intervention. Interventions last Monday, Wednesday and Friday of each week, with an average duration of one hour. Group medical play include: medical picture book education, medical preview game, emotional games, social table games. Two groups completed self-made questionnaires at the time of admission and two weeks after admission, including: diet, sleep, compliance, and social status, hospital adaptation and other related issues, two groups completed a satisfaction questionnaire after two weeks of admission, recorded analysis and compared the difference of questionnaire data and satisfaction of the two groups of pediatric patients. RESULTS There was no statistical difference in age and sex between the two groups, and there was no significant difference in baseline RESULTS: The re-test results showed that the experimental group was significantly better than the control group in terms of social status, hospital adaptation, compliance and family satisfaction(p＜0.05). CONCLUSION Group medical games can effectively improve the adaptability, compliance and family satisfaction of pediatric with neuro tumor.

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