scholarly journals Primary ovarian malignant melanoma

2010 ◽  
Vol 67 (3) ◽  
pp. 252-255
Author(s):  
Milos Kostov ◽  
Biserka Vukomanovic-Djurdjevic ◽  
Dane Nenadic ◽  
Milos Pavlovic
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Primary Melanoma ◽  
Histopathological Diagnosis ◽  
Solid Mass ◽  
Diagnostic Problem ◽  
S 100 ◽  
Black Color ◽  
Immunohistochemical Analyses ◽  
Hmb 45

Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

scholarly journals Metastatic malignant ovarian melanoma: A case report

2013 ◽  
Vol 70 (2) ◽  
pp. 229-232 ◽  
Author(s):  
Milica Berisavac ◽  
Biljana Kastratovic-Kotlica ◽  
Igor Pilic ◽  
Jasmina Atanackovic
Keyword(s):  
Case Report ◽  
Progesterone Receptors ◽  
Histopathological Diagnosis ◽  
Solid Structure ◽  
Previous Diagnosis ◽  
S 100 ◽  
Macroscopic Examination ◽  
Infracolic Omentectomy ◽  
Immunohistochemical Analyses

Background. Malignant melanomas of the female reproductive system are rare. These are biologically highly aggressive tumors with poor prognosis. Preoperative establishment of the diagnosis is practically impossible. Therapeutic approach and treatment of patients with metastatic ovarian melanoma are highly dependent on precise histological analysis. Case report. A woman aged 48 was admitted to the clinic for occasional pains in the lower abdomen and suspected myomatous changes of the uterus. The patient underwent surgery for melanoma on her right arm five years ago. Classic hysterectomy with bilateral adnexectomy with infracolic omentectomy and selective iliac lymphadenectomy were performed. Macroscopic examination revealed an oval tumefaction on the left ovary sized 12.5 x 10 x 3.5 cm of solid structure. Tumor tissue was yellowish-brown colored, of solid structure and mostly localized subcortically with central edema. Microscopic examination showed positive reaction for HMB-45, anti-Melan-A and S-100 protein, but negative immunoreactivity for estrogen and progesterone receptors. Malignant disease caused death after a 4-year follow-up period following gynecological operation. Conclusion. The previous diagnosis of skin melanoma is also indicative of metastatic ovarian tumor, while immunohistochemical analyses confirmed the histopathological diagnosis.

scholarly journals Malignant melanoma of the bladder: A case report

2014 ◽  
Vol 8 (1-2) ◽  
pp. 54 ◽  
Author(s):  
Hamide Sayar ◽  
Seyda Erdogan ◽  
Fulya Adamhasan ◽  
Esma Gurbuz ◽  
Mehmet Fatih İnci
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Immunohistochemical Staining ◽  
Correct Diagnosis ◽  
Primary Lesion ◽  
Histological Features ◽  
Malignant Melanomas ◽  
Metastatic Lesions ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of the bladder is very rare. Rather than being a primary lesion, malignant melanomas of the bladder are more commonly metastatic lesions. The histopathological appearance largely does not differ from that of melanoma at other body sites. It is often difficult to discriminate whether a bladder melanoma is primary or metastatic. Therefore, a careful review of histological features and performing necessary immunohistochemical staining procedures for S-100 protein and HMB-45 are very important in achieving a correct diagnosis. We report a case of hypomelanotic malignant melanoma of the bladder. Despite the variety of therapies available for primary melanomas of the bladder, the prognosis is still poor.

scholarly journals A Case of Primary Subglottic Malignant Melanoma with a Successful Surgical Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Shahzad Ahmad ◽  
Mahmoud Abdelghany ◽  
Curtis Goldblatt ◽  
Owen Stark ◽  
Nicholas Masciotra
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Excisional Biopsy ◽  
Human Melanoma ◽  
Primary Malignant Melanoma ◽  
Shortness Of Breath ◽  
S 100 ◽  
Hmb 45

Primary subglottic malignant melanoma is a very rare and underdiagnosed neoplasm. We are reporting a case of primary malignant melanoma of subglottic mucosa in a 78-year-old woman who presented to our hospital with shortness of breath and hoarseness of voice. Laryngoscopy and excisional biopsy along with immunoreactivity to S-100 and human melanoma black-45 (HMB-45) confirmed the diagnosis. The patient was treated with laryngectomy followed by radiotherapy. Five years following surgical treatment, she continues to be asymptomatic. To our knowledge, there is only one reported case of primary malignant melanoma of subglottic mucosa in the medical literatures.

scholarly journals Primary Melanoma of the Lung: A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 576
Author(s):  
Panagiotis Paliogiannis ◽  
Antonella M. Fara ◽  
Gianfranco Pintus ◽  
Wael M. Abdel-Rahman ◽  
Maria Colombino ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Single Case ◽  
Left Lung ◽  
Case Series ◽  
Primary Melanoma ◽  
Primary Malignant Melanoma ◽  
S 100 ◽  
Main Determinants ◽  
Mitotic Figures ◽  
Rare Malignancy

Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has been performed using keywords, and the references of the selected articles were checked to identify additional missing studies. Results: Globally 52 papers reporting on 76 cases were identified. Among them there were 47 reports of a single case, three papers reporting on two cases each, and two larger case series published in 1997 and 2005 including eight and 15 cases, respectively. Conclusions: PMML was generally diagnosed in middle-aged males, without any apparent correlation with cigarette smoking. It was more frequently found in the lower lobes and the left lung. The tumors were generally pigmented, composed by epithelial and/or spindle cells with large nuclei and prominent nucleoli, nuclear atypia, and numerous mitotic figures; they commonly showed immunostaining for S-100, HMB 45 and Melan-A. Early detection and surgical resection were the main determinants of survival from this rare malignancy.

scholarly journals Primary malignant melanoma of the nipple: a case report

2021 ◽  
Vol 10 (12) ◽  
pp. 4553
Author(s):  
Moukit Mounir ◽  
Aziz Bazine ◽  
Mohammed Rahmoune ◽  
Ismail Allilou ◽  
Bouchra Elmoubakkir ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Malignant Melanoma ◽  
Axillary Lymph Node ◽  
Primary Melanoma ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Superficial Spreading ◽  
Non Invasive ◽  
Left Nipple

Primary melanoma origi­nating on the female nipple remains an extremely rare variant of malignant melanoma and only a few cases haves been reported in the literature. We describe a case of a patient admitted for a black pigment deposition on the left nipple. Surgical resection of the left nipple and areola with clear margins and an axillary lymph node dissection was performed confirming the diagnosis of non-invasive superficial spreading melanoma.

scholarly journals TRICHILEMMAL CYSTIS IN METASTATIC MELANOMA: A CASE REPORT

2017 ◽  
Vol 39 (1) ◽  
pp. 86-87
Author(s):  
I Savarese ◽  
M Grazzini ◽  
A Gori ◽  
A D’Errico ◽  
L Doni ◽  
...  
Keyword(s):  
Case Report ◽  
Systemic Sclerosis ◽  
Malignant Melanoma ◽  
Brain Metastasis ◽  
Metastatic Melanoma ◽  
Primary Melanoma ◽  
Paraneoplastic Syndromes ◽  
Frontal Region ◽  
Unknown Primary ◽  
Paraneoplastic Pemphigus

The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus. We describe a case of four multiple trichilemmal cystis arising on frontal region in the same patient with brain metastasis and unknown primary melanoma and discuss their relationship.

scholarly journals Evaluation of Immunohistochemical Reactivity with Avidin-Biotin Complex (ABC) Method

2018 ◽  
Vol 3 (3) ◽  
pp. 909-918
Author(s):  
C. Sandoval ◽  
B. Vásquez
Keyword(s):  
Malignant Melanoma ◽  
Primary Antibody ◽  
Histopathological Diagnosis ◽  
Distilled Water ◽  
Correct Interpretation ◽  
S 100 ◽  
Antibody Reaction ◽  
Abc Method ◽  
Antigen Antibody ◽  
Avidin Biotin Complex

Immunohistochemistry is any technique that can detect cellular and extracellular components in situ by means of specific antibodies, using enzymatic detection systems. Among immunohistochemical methods, the technique of avidin - biotin complex (ABC) is widely used because of its high sensitivity. The aim of this study was to evaluate the immunohistochemical reactivity of the 4C4.9 antibody for detection of S-100 protein using the ABC method. For the evaluation of immunohistochemical reactivity 2 biopsies of human skin were used with histopathological diagnosis of ulcerated malignant melanoma and melanocytic intradermal nevi from the Research Laboratory on Animal Biotechnology of the Universidad de La Frontera, Chile. The Kit VECTASTAIN® was used as detection method, the dilution the 4C4.9 antibody was 1/250 and incubation temperature was at 4 ° C or 37 °C for 18 hours. To validate the technique, a positive control and a negative for 4C4.9 was performed. The results of immunohistochemical staining by the method of ABC complex showed positive staining for protein S-100 both in ulcerated malignant melanoma and melanocytic intradermal nevi, incubated for 18 hours at 4 ° C or 37 ° C. However, immunostaining was more intense when the primary antibody was incubated at 37° C. For a correct interpretation of the results, it is necessary to take into consideration that the antigen-antibody reaction is influenced by various factors such as the concentration of antibody, time and temperature of incubation. In conclusion, our results suggest incubating the samples with the first antibody (4C4.9) at 1/250 dilution in distilled water, incubating for 18 h at 37 oC. However, immunostaining was more intense when the primary antibody was incubated at 37° C. For a correct interpretation of the results, it is necessary to take into consideration that antigen- antibody reaction is influenced by various factors such as the concentration of antibody, time and temperature of incubation. In conclusion, our results suggest incubating the samples with the first antibody (4C4.9) at 1/250 dilution in distilled water, incubating for 18 h at 37 oC. The use of the antibody 4C4.9 is recommended to support the diagnosis and differential diagnosis.

Primary Mucosal Malignant Melanoma of the Larynx: Case Report and Review of the Literature

1995 ◽  
Vol 81 (6) ◽  
pp. 460-463 ◽  
Author(s):  
Franco Mattavelli ◽  
Silvana Di Palma ◽  
Marco Guzzo
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Malignant Tumor ◽  
Primary Melanoma ◽  
Review Of The Literature ◽  
Laryngeal Mucosa ◽  
Mucosal Malignant Melanoma ◽  
Primary Mucosal Malignant Melanoma ◽  
Disseminated Disease

We report a case of primary melanoma of the larynx in a patient who died of disseminated disease 13 months later. It is a rare malignant tumor in the head and neck, accounting for 0.4-10% of all melanomas of this site. Histologically, the presence of in situ changes within the laryngeal mucosa strongly supports our diagnosis of primary melanoma of the larynx.

scholarly journals Clinicohistopathological Characteristics of Malignant Melanoma in the Gall Bladder: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Schmidt Adrian ◽  
Caspar Clemens ◽  
Schmidt-Weiss Elisabeth ◽  
Stadlmann Sylvia
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Gall Bladder ◽  
Metastatic Melanoma ◽  
Primary Melanoma ◽  
Review Of The Literature ◽  
Melanoma Patients

Objective. Primary gall bladder melanoma is a rare and controversial entity. So far, only 36 cases are documented in the literature. Metastatic melanoma targeting the gall bladder, however, has been reported to occur in about 15–20% of melanoma patients and is much more common. Methods. Based on the case of a 58-year-old woman presenting with multiple melanoma nodules in the gall bladder, we searched in the available literature in PubMed for articles describing a “primary melanoma of the gallbladder” regardless of language used. Results. We detected 33 papers that described 36 cases of primary gall bladder melanoma between 1907 and 2017. From different criteria distinguishing primary and secondary gall bladder melanoma, generally, the following were accepted: (1) exclusion of previous primary melanoma, (2) absence of synchronous involvement of other sites, (3) unicity of the lesion, (4) polypoid or papillary shape of the lesion, and (5) presence of junctional melanocitary component. Review of the 36 published cases revealed that only about one-fourth of them fulfilled all the five criteria. Conclusion. Primary gall bladder melanoma is even rarer than described in the literature, and the question whether this entity really exists remains open.

scholarly journals Case report of vaginal melanoma

2016 ◽  
Author(s):  
Inderjit Kaur ◽  
Swarupa Mitra ◽  
Manoj Kumar Sharma ◽  
Upasna Saxena ◽  
Parveen Ahlawat ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Soft Tissue ◽  
Invasive Carcinoma ◽  
Positive Margin ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Full Thickness ◽  
Vaginal Cuff ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of vagina is a rare disease with a predilection for local recurrence, distant metastasis and short survival time. Due to the low incidence and lack of reporting in the literature, treatment choices still remain controversial. We describe 2 cases of vaginal malignant melanoma. A 42 yr old female presented with complaints of post coital and per vaginal bleed of 1 month duration. Examination findings show growth 6 cm x 6 cm on anterior vaginal wall, another 3 x 3 cm lesion on right lateral vaginal wall. Vaginal biopsy showed malignant melanoma, S-100 and HMB-45 positive while negative for CK and LCA. MRI Whole abdomen showed altered lesion [3.8cm (AP), 6.0cm (TR) and 4.9cm (CC)] in upper 2/3rd of vagina extending into vaginal fornices and abutting right lower cervix superiorly, right paravaginal extension and mesorectal fascia. No significant enlarged lymph nodes were seen. In view of localised disease she underwent Type III Radical hysterectomy with bilateral salpingo-ophorectomy with bilateral pelvic lymphnode dissection with total vaginectomy. Histopathology s/o 2 tumour nodules, one located in the anterior vaginal cuff measuring – 5 x 5 x 3.2 cm, another located in right lateral vaginal cuff measuring 2.5 x 3 x 1.5 cm, malignant melanoma with involvement of the cervix with full thickness stromal invasion (2.8/2.8 cm,) invading perivaginal soft tissue, distance of invasive carcinoma from closest stromal margin <0.1cm (12 O’ clock), LVI, PNI – not seen, all pelvic LN free (0/25). In view of positive margin and full thickness stromal involvement, she received radiotherapy to pelvis and Inguinal region to a dose of 45 Gy/25# followed by a boost of 16 Gy/8# to the tumour bed till 01/01/16. Another case is a 40 yrs female, presented with complaints of bloody discharge per vaginum of 4 months duration. On examination, there was a large growth occupying the vagina till introitus. Cervix normal, para free. MRI Pelvis showed altered lesion involving left lateral uterine cervix and upper 2/3rd of vagina with full thickness stromal involvement with mild left parametrial, anterior and posterior paravaginal extension, measuring 2.9 x 4.5 x 5.3 cm. Few subcmlymphnodes were seen in bilateral external and internal iliac regions (L>R). Vaginal Biopsy was suggestive of Malignant Melanoma, expressing S-100, HMB 45 and SDX-10. Metastatic work up was negative. She underwent RH with total vaginectomy with bilateral PLND with RPLND. HPR showed exophytic black growth seen involving all quadrants of vagina, extending upwards into both lips of cervix – 7 x 6 x 2.5 cm, Malignant melanoma, distance of invasive carcinoma from closest margin: <0.1 cm (paravaginal soft tissue), 3/8 right Pelvic LN, ECE +, 01/9 Left pelvic LN, ECE absent, 0/6 Right common iliac LN, 0/1 Reperitoneal LN was seen. She received adjuvant radiotherapy to a dose of 50 Gy/25# to the pelvis and inguinals→ boost of 6 Gy/3# to nodal regions showing ECE & 10 Gy/5# to the primary region.

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