scholarly journals Angiogenesis in squamous precancerous cervical lesions

2007 ◽  
Vol 64 (1) ◽  
pp. 7-11
Author(s):  
Milan Panjkovic ◽  
Tatjana Ivkovic-Kapicl
Keyword(s):  
Endothelial Cells ◽  
High Grade ◽  
Microvessel Count ◽  
Cervical Lesions ◽  
Cervical Epithelium ◽  
Tissue Sections ◽  
Normal Cervical Epithelium ◽  
Vascular Structures ◽  
The Mean ◽  
Precancerous Cervical Lesions

Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between stromal angiogenesis and the grade of cervical intraepithelial changes (CIN). Methods. The tissue sections of 50 cone biopsies were immunohistochemically stained for CD31 antigen, a marker for endothelial cells. All microvessels along the basement membrane subtending dysplastic epithelium were counted. The mean microvessel count was calculated from the three separate fields for each specimen. All the cases were devided into four groups: normal cervical epithelium (n = 5), CIN1 (n = 7), CIN2 (n = 13), and CIN3 (n = 25). Results. The mean microvessel count (MVC) under the dysplastic epithelium was 18.1. For the patients with CIN1 changes the mean MVC was 12.9, while this number was 18.72 and 19.24 for the patients with CIN2 and CIN3 grade of epithelial changes, respectively. In a subset of the high grade lesions vascular structures were also noted in the upper layer of the epithelium. The mean MVC in the cases with the presence of these structures was 22, while this number was 12.91 in the cases without intraepithelial vessels. Although we found an increase of the mean MVC with the increase of the CIN grade, statistically significant differences were found out between CIN1 and CIN3 lesions. The mean MVC of the patients with the presence of intraepithelial vessels was statistically higher than the mean MVC of the patients without these structures. Conclusion. On the basis of the obtained results, we can conclude that the mean MVC and CIN grade positively correlated, while the number of cases with intraepithelial vessels increased with the CIN grade.

scholarly journals Preferences for surveillance strategies for women treated for high-grade precancerous cervical lesions

2010 ◽  
Vol 118 (2) ◽  
pp. 108-115 ◽  
Author(s):  
M. Kuppermann ◽  
J. Melnikow ◽  
C. Slee ◽  
D.J. Tancredi ◽  
S. Kulasingam ◽  
...  
Keyword(s):  
High Grade ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions

scholarly journals Management of Abnormal Cervical Cytology: Atypical Squamous Cells of Undetermined Significance (ASC-US) and Atypical Squamous Cells cannot exclude High Grade Intraepithelial Lesion (ASC-H)

2016 ◽  
pp. 166-170
Author(s):  
Fitriyadi Kusuma ◽  
Mediana S. Liedapraja
Keyword(s):  
Cervical Cytology ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Squamous Cells ◽  
Abnormal Cervical Cytology ◽  
Definitive Therapy ◽  
Intraepithelial Lesion ◽  
Precancerous Cervical Lesions ◽  
Undetermined Significance

Objective: To review for the management of abnormal cervical cytology: atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells cannot exclude high-grade intraepithelial lesion (ASC-H) as a treatment of cervical precancerous lesions in order to avoidexcessive treatment, reduce of unnecessary examinations and to provide cost effectively. Method: Literature study on published literatures and studies about the management of cervical cytology. Conclusion: The results of ASC-US cervical cytology and ASC-H is aninitial screening to detect precancerous cervical lesions. Definitive therapy should be done when finding a low-grade lesions (LSIL) and high degree of lesion(HSIL) squamous intraepithelial. A clinician expected to understand the natural history of HPV infection and the management of precancerous cervical lesions properly. [Indones J Obstet Gynecol 2013; 37-3: 166-170] Keywords: ASC-H, ASC-US, cervical cytology abnormalities, cervical precancerous lesion.

The “See and Treat” Strategy for Identifying Cytologic High-Grade Precancerous Cervical Lesions Among Low-Income Brazilian Women

2012 ◽  
Vol 67 (11) ◽  
pp. 703-705
Author(s):  
Paula R.B. Nogara ◽  
Luís A.R. Manfroni ◽  
Mariana C. da Silva ◽  
Marcia E.L. Consolaro
Keyword(s):  
Low Income ◽  
High Grade ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions

The “see and treat” strategy for identifying cytologic high-grade precancerous cervical lesions among low-income Brazilian women

2012 ◽  
Vol 118 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Paula R.B. Nogara ◽  
Luís A.R. Manfroni ◽  
Mariana C. da Silva ◽  
Marcia E.L. Consolaro
Keyword(s):  
Low Income ◽  
High Grade ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions

scholarly journals Identification of human papillomavirus type 16 integration sites in high-grade precancerous cervical lesions

2009 ◽  
Vol 113 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Mihaela Matovina ◽  
Ivan Sabol ◽  
Goran Grubišić ◽  
Nina Milutin Gašperov ◽  
Magdalena Grce
Keyword(s):  
Human Papillomavirus ◽  
High Grade ◽  
Cervical Lesions ◽  
Human Papillomavirus Type 16 ◽  
Integration Sites ◽  
Precancerous Cervical Lesions

scholarly journals Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Akouélé P. Kuassi-Kpede ◽  
Essolakina Dolou ◽  
Théodora M. Zohoncon ◽  
Ina Marie Angèle Traore ◽  
Gnatoulma Katawa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
West Africa ◽  
Public Health Problem ◽  
Hpv Infection ◽  
Cervical Lesions ◽  
Hpv Genotypes ◽  
Precancerous Cervical Lesions ◽  
High Risk Hpv ◽  
First Time

Abstract Background The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order to fill the knowledge gap in the field in Togo, the main objective of this study was to determine the prevalence of pre-cancerous lesions of the cervix and HR-HPV genotypes among Togolese women. Methods Samples were collected from 240 women by introducing a swab in the cervix. Then, the screening of precancerous cervical lesions using the visual inspection with acetic acid and lugol (VIA / VIL) was conducted. The HR-HPV genotypes were characterised by real-time multiplex PCR. Results Out of 240 women recruited, 128 (53.3%) were infected by HR-HPV. The most common genotypes were HPV 56 (22.7%), followed by HPV 51 (20.3%), HPV 31 (19.5%), HPV 52 (18.8%) and HPV 35 (17.2%). The least common genotypes were HPV 33 (2.3%) and HPV 16 (2.3%). Among the women, 1.3% (3/240) were positive to VIA/VIL. Conclusion This study allowed HR-HPV genotypes to be characterised for the first time in Lomé, Togo. This will help in mapping the HR-HPV genotypes in West Africa.

scholarly journals The value of the added diffusion-weighted images to multiparametric MRI in the early diagnosis of uterine cervix cancers and nodal assessment

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Nasr Mohamed Osman ◽  
Mohamed Aboul-fotouh Mourad
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Multiparametric Mri ◽  
Lesion Group ◽  
Cervical Lesions ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Group I ◽  
Malignant Lesions ◽  
The Mean

Abstract Background Cervical cancer still one of the most common causes of tumor-related death in developing countries presented in younger women. In this study, we aimed to evaluate the value of diffusion-weighted MRI in early diagnosis of malignant cervical lesions, to assess metastatic adenopathy, peritoneal dissemination, and possible tumor recurrence, and determine treatment response. This study included 60 patients with abnormal vaginal bleeding and suspected cervical lesion by US. A histopathological biopsy was done. Pelvic MR with DWI and dynamic contrast-enhanced MRI were done for all patients. Results According to the histopathological findings, we divided our studied 60 patents into two groups: group I, malignant lesions (46 lesions; 76.7%), and group II, benign lesions (14 lesions; 23.3%). Multiparametric MRI could detect all cervical lesions but with poor pathologic characterization, achieving 72.37% sensitivity, 37.50% specificity, 63.33% accuracy, 76.19% PPV, and 33.33% NPV. When compared with DWI with ADC value measurements at high b value (b = 800) to MRI exam, it showed a higher diagnostic accuracy with good lesion pathological characterization that achieved 95.65% sensitivity, 71.43% specificity, 90% accuracy, 91.67 PPV, and 83.33% NPV. The mean ADC value for malignant lesions was 0.86–1.1, mean = 0.92 ± 0.71 × 10−3 mm2/s, while the mean ADC value in the benign lesion group was 1.18 ± 0.1 × 10–3 mm2/s. Conclusion Comparing DWI with ADC values measurements at high b value to the multiparametric MRI examination of the female pelvis increases the sensitivity, specificity, and diagnostic accuracy of characterization and early diagnosis of cervical malignant focal lesions and reduces the need for intravenous contrast administration.

scholarly journals Usefulness of p16INK4a staining for managing histological high-grade squamous intraepithelial cervical lesions

2016 ◽  
Vol 30 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Ester Miralpeix ◽  
Jordi Genovés ◽  
Josep Maria Solé-Sedeño ◽  
Gemma Mancebo ◽  
Belen Lloveras ◽  
...  
Keyword(s):  
High Grade ◽  
Cervical Lesions
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