scholarly journals Usefulness of p16INK4a staining for managing histological high-grade squamous intraepithelial cervical lesions

2016 ◽  
Vol 30 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Ester Miralpeix ◽  
Jordi Genovés ◽  
Josep Maria Solé-Sedeño ◽  
Gemma Mancebo ◽  
Belen Lloveras ◽  
...  
Keyword(s):  
High Grade ◽  
Cervical Lesions

scholarly journals CD4+ T cells against human papillomavirus-18 E7 in patients with high-grade cervical lesions associate with the absence of the virus in the cervix

Immunology ◽  
2010 ◽  
pp. no-no ◽  
Author(s):  
Samantha Seresini ◽  
Massimo Origoni ◽  
Luigi Caputo ◽  
Flavia Lillo ◽  
Renato Longhi ◽  
...  
Keyword(s):  
T Cells ◽  
Human Papillomavirus ◽  
Cd4 T Cells ◽  
High Grade ◽  
Cervical Lesions ◽  
Human Papillomavirus 18

Chromosomal Signatures of a Subset of High-Grade Premalignant Cervical Lesions Closely Resemble Invasive Carcinomas

2009 ◽  
Vol 69 (2) ◽  
pp. 647-655 ◽  
Author(s):  
Saskia M. Wilting ◽  
Renske D.M. Steenbergen ◽  
Marianne Tijssen ◽  
Wessel N. van Wieringen ◽  
Theo J.M. Helmerhorst ◽  
...  
Keyword(s):  
High Grade ◽  
Cervical Lesions ◽  
Invasive Carcinomas

Detection of human papillomavirus 67 single infection in high‐grade cervical lesions: Case report and review of literature

2018 ◽  
Vol 47 (3) ◽  
pp. 251-254
Author(s):  
Steven Van Schandevyl ◽  
Liselotte Coorevits ◽  
Jerina Boelens ◽  
Ans Traen ◽  
Luc Bingé ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Case Report ◽  
Single Infection ◽  
High Grade ◽  
Review Of Literature ◽  
Cervical Lesions

scholarly journals High-risk HPV genotypes and cervical lesions association in postmenopausal women

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Ana Rita Fernandes Miranda da Costa ◽  
Cláudia Sousa ◽  
Erica Isidoro ◽  
Regina Silva ◽  
Cristiana Mourato
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Age Groups ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Intraepithelial Lesion ◽  
The Bethesda System ◽  
High Risk Hpv

Abstract Background Persistent infection by high-risk Human Papillomavirus (hrHPV) are the major cause of cervical cancer. Studies report disparities in the incidence of infection and the various genotypes of this virus in different age groups, suggesting a higher frequency of hrHPV in young women and low-risk subtypes being predominant in older women. This study aimed to investigate the incidence and distribution of hrHPV genotypes in postmenopausal women as well as the correlation with the cytological findings. Methods 16 859 women, aged 50–64 years, performed cervical cancer screening test in Friuri Venezia Giulia region, Italy. The infection was evaluated by the Polymerase Chain Reaction methodology and the positive samples were evaluated by Liquid Based Cytology according to the Bethesda System from 2014. A statistical analysis was performed to study the molecular and cytological data of this population. Results hrHPV infection were found in 5.8% of the women and 78.3% of these were caused by hrHPV other than HPV16 and HPV18 (). Also, 65.7% of the positive samples were negative for intraepithelial lesion or malignancy while low grade squamous intraepithelial lesion was the most frequent (22.4%). There was an increase in the number of high-grade intraepithelial lesions in the presence of HPV16 compared to that recorded when this genotype was absent (20.8% vs. 8.5%). No cervical cancers were detected. Conclusions Infection with hrHPV is uncommon in postmenopausal women and it is mostly caused by subtypes less associated with the development of cervical cancer. Yet, HPV16 infection triggers the development of high-grade lesions.

scholarly journals Abnormal colposcopic images in patients with preinvasive cervical lesions

2013 ◽  
Vol 3 (2) ◽  
pp. 98-102
Author(s):  
Adnan Babović ◽  
Dženita Ljuca ◽  
Gordana Bogdanović ◽  
Lejla Muminhodžić
Keyword(s):  
Intraepithelial Neoplasia ◽  
Control Group ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Cytological Examination ◽  
Chi Square ◽  
Chi Square Test ◽  
Intraepithelial Lesion ◽  
Experimental Group

Introduction: The objective of the study was to determine frequency and to compare frequency of the abnormal colposcopic images in patients with low and high grade pre-invasive lesions of cervix.Methods: Study includes 259 patients, whom colposcopic and cytological examination of cervix was done. The experimental group of patients consisted of patents with pre-invasive low grade squamousintraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL), and the control group consisted of patients without cervical intraepithelial neoplasia (CIN).Results: In comparison to the total number of satisfactory fi ndings (N=259), pathological findings were registered in N=113 (43.6 %) and abnormal colposcopic fi ndings in N=128 (49.4%). The study did notinclude patients with unsatisfactory fi nding N=22 (8.5%). Abnormal colposcopic image is present most frequently in older patients but there are no statistically important difference between age categories(Pearson Chi-Square 0.47, df -3, p=0.923). Frequency of abnormal colposcopic fi ndings (N=128) is the biggest in pathological cytological (N=113) and HSIL 58 (45.3%), LSIL 36 (28.1%). There is statisticallysignifi cant difference in frequency of abnormal colposcopic images in patients with low-grade in comparison to patients with high-grade pre-invasive cervix lesions (Chi-Square test, Pearson Chi-Square 117.14,df-12 p<0.0001).Conclusion: Thanks to characteristic colposcopic images, abnormal epithelium is successfully recognized, but the severity grade of intraepithelial lesion cannot be determined.

Sign in / Sign up

Export Citation Format

Share Document