scholarly journals Mucous patch on the tongue as isolated manifestation of the secondary stage of syphilis: Case report

2012 ◽  
Vol 59 (3) ◽  
pp. 160-163
Author(s):  
Milan Bjekic ◽  
Sandra Sipetic
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Secondary Syphilis ◽  
Oral Lesions ◽  
Oral Diseases ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
Systemic Antibiotic Therapy ◽  
Secondary Stage

Introduction. Syphilis is sexually transmitted infection caused by the anaerobic spirochete Treponema pallidum. Oral lesions are present and described in all stages of the disease. These lesions as well as blood and saliva of infected persons are highly contagious in early syphilis. The aim of this case report was to point out to the possibility of the secondary syphilis in differential diagnosis of oral diseases. Case Report. A 38-year-old asymptomatic man showed up at the clinic with suspicious of syphilis infection. Clinical presentation of the disease was a mucous patch on the tongue, however no other mucous membrane or cutaneous lesions were detected. No lymph nodes were enlarged. The serologic tests on syphilis were positive. After conducting systemic antibiotic therapy with benzathine penicillin the tongue lesion disappeared. Conclusion. Depending on the clinical picture, the possibility of syphilis should not be overlooked in the differential diagnosis of oral lesions.

scholarly journals Condyloma Latum on the Lower Lip as an Isolated Manifestation of Secondary Syphilis – a Case Report

2016 ◽  
Vol 8 (1) ◽  
pp. 45-50
Author(s):  
Milan Bjekić ◽  
Kiro Ivanovski
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
World Literature ◽  
Systemic Disease ◽  
Secondary Syphilis ◽  
The Body ◽  
Oral Lesions ◽  
Lower Lip ◽  
Secondary Stage ◽  
History Of

Abstract Oral lesions are described in all stages of syphilis, except in the latent stage. During the secondary stage of infection, oral lesions, saliva and blood of infected person are very contagious. The aim of this case report was to point to the secondary syphilis in differential diagnosis of oral diseases. A 30-year-old homosexual man presented with a three-week history of a painless verrucous lesion on his lower lip. Physical examination revealed a hypertrophic painless papillomatous lesion on the lower lip. The lesion was partly split with peripheral fissures. There were no generalized lymphadenopathies and no evidence of systemic disease. Further examination showed no other mucous membrane or cutaneous lesions elsewhere on the body. The external genitalia were normal. The patient was HIV-negative and otherwise healthy. A review of his medical history was significant for previous well documented treatment of anal chancre, which was successfully commenced at our Institute in 2010. It also revealed a history of a single unprotected receptive oral sex with an unknown partner 3 months before the onset of lesion. The diagnosis of condyloma latum on the lower lip was considered on clinical grounds. Laboratory findings, including complete blood count and blood chemistry were within normal limits. The VDRL (venereal disease research laboratory) test was positive with a titre of 1 : 128. Treponema pallidum hemagglutination assay (TPHA) was positive. HIV serology was non-reactive. The final diagnosis of solitary condyloma latum on the lower lip, as the only sign of secondary syphilis, was confirmed by positive results of routine serologic tests for syphilis. The patient was diagnosed with secondary syphilis and treated with a single intramuscular injection of benzathine penicillin, 2.4 million units. The lesion regressed completely within 2 weeks. Three months later the VDRL titer had fallen to 1 : 8 and HIV serology remained negative. Polymorphic oral manifestations in syphilis indicate that this disease should not be overlooked in the differential diagnosis of not only benign, but even malignant oral lesions. In conclusion, as far as the world literature available to us is concerned, this would be the first report of isolated solitary condyloma latum on the oral lip that, in the absence of any other clinical signs or symptoms of the disease, led to the diagnosis of secondary syphilis.

Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions

2017 ◽  
Vol 29 (4) ◽  
pp. 410-413 ◽  
Author(s):  
Linda Tognetti ◽  
Elisa Cinotti ◽  
Sergio Tripodi ◽  
Guido Garosi ◽  
Pietro Rubegni
Keyword(s):  
Membranoproliferative Glomerulonephritis ◽  
Congenital Syphilis ◽  
Renal Involvement ◽  
Treponema Pallidum ◽  
Membranous Glomerulonephritis ◽  
Secondary Syphilis ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Cutaneous Manifestations ◽  
Nephritic Syndrome

The worldwide re-emergence of secondary syphilis which happened in the last decade, has led to an increase in primary and secondary syphilis cases, along with the presentation of atypical forms. Nevertheless, reports of renal syphilis with mucosal and/or cutaneous manifestations are nowadays increasing. Typically, secondary syphilis infection in adults causes nephrotic syndrome due to a membranous glomerulonephritis. Here, we report a case of a 30-year-old immunocompetent man presenting with skin rash, oral and perianal erosions and nephritic syndrome. Laboratory investigations revealed a form of membranoproliferative glomerulonephritis secondary to Treponema pallidum infection. Therapy with benzathine penicillin brought prompt and complete remission of the disease. Although well described for congenital syphilis, this histopathologic pattern of renal involvement is very rarely reported in adult patients. In case of detection of an otherwise unexplained nephritic syndrome in sexually active patients with mucosal and/or anal lesions, an unrecognized syphilis infection should be suspected.

scholarly journals Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association

2019 ◽  
Vol 8 (1) ◽  
pp. 114
Author(s):  
Alejandra Orozco Guillén ◽  
Ricardo Velazquez Silva ◽  
Bernardo Moguel González ◽  
Yubia Guell ◽  
Pamela Garciadiego Fossas ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Neonatal Intensive Care ◽  
Kidney Biopsy ◽  
Secondary Syphilis ◽  
Uncontrolled Hypertension ◽  
Syphilis Infection ◽  
Negative Results ◽  
Postinfectious Glomerulonephritis ◽  
Mother And Child ◽  
Clinical Conditions

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Based on hypertension and nephrotic proteinuria, she was initially diagnosed with PE. Immunological tests, as well as hepatitis and HIV tests showed negative results. However, secondary syphilis was diagnosed. In discordance with the PE diagnosis, urinalysis showed glomerular microhematuria with cellular casts. Proteinuria and hypertension did not remit after delivery, which was made via caesarean section, due to uncontrolled hypertension, at an estimated gestational age of 29 weeks. A male baby, weighing 1.1 kg (6.5 centile) was born. The baby was hospitalized in the neonatal intensive care unit, where he developed subependymal hemorrhage and thrombocytopenia, and neonatal syphilis was diagnosed. The mother underwent a kidney biopsy one week after delivery, leading to the diagnosis of IgA-dominant postinfectious glomerulonephritis. Mother and child were treated with support and antibiotic therapy, and were discharged in good clinical conditions four weeks later. Four months after delivery, the mother was normotensive without therapy, with normal kidney function and without hematuria or proteinuria. In conclusion, this case suggests that IgA-dominant postinfectious glomerulonephritis should be added to the spectrum of syphilis-associated glomerulonephritides, and underlines the need for a careful differential diagnosis with CKD in all cases of presumed PE. While diagnosis relies on kidney biopsy, urinary sediment, a simple and inexpensive test, can be the first step in distinguishing PE from other nephropathies.

scholarly journals Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Walter de Araujo Eyer-Silva ◽  
Maria Alessandra Leite Freire ◽  
Cecília Angelina Horta-Araujo ◽  
Guilherme Almeida Rosa da Silva ◽  
Jorge Francisco da Cunha Pinto ◽  
...  
Keyword(s):  
Secondary Syphilis ◽  
Oral Lesions ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Infected Male ◽  
Full Spectrum ◽  
Posterior Aspect ◽  
Complete Clinical Remission ◽  
Penicillin Therapy ◽  
Oral Commissure

Syphilis has been coined “the great imitator” due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchée. A painful split papule (fausse perlèche or false angular cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.

scholarly journals Erythema multiform-like lesions in a patient infected with SARS-CoV-2: a case report

2021 ◽  
Author(s):  
Yaser Fathi ◽  
Elaheh Ghasemzadeh Hoseini ◽  
Reza Mottaghi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Hypersensitivity Reaction ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Erythema Multiforme ◽  
Distress Syndrome ◽  
Oral Lesions ◽  
Oral Ulceration

Background: SARS-CoV-2, is followed by several manifestations, such as fever, cough, respiratory distress syndrome and mucocutaneous lesions such as papules, urticaria, vasculitic purpura and erythema multiform. Case: A 22-year old woman was diagnosed with COVID-19. Considering the skin and oral lesions, erythema multiform was suggested as the most likely diagnosis. Oral valaciclovir was administered. Discussion: Erythema multiforme were reported in some patients with COVID-19. Its pathophysiology is not yet completely understood, but it seems there is a lymphocyte-mediated hypersensitivity reaction to SARS-CoV-2 antigens presenting in the skin. Conclusion: Mucocutaneous and oral lesions might be the first manifestations of COVID-19. Therefore, during the pandemic, it is prudent to consider this virus as a differential diagnosis once we encounter oral ulceration.

scholarly journals Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Robert Jame ◽  
Yousif Al-Saeigh ◽  
Leo L. Wang ◽  
Kevin Wang
Keyword(s):  
Undetectable Viral Load ◽  
Secondary Syphilis ◽  
Warning Signs ◽  
Penicillin G ◽  
Hiv Positive ◽  
Ocular Infection ◽  
Blurred Vision ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
History Of

Background. An estimated 25% of primary and secondary syphilis, a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum, occurs in patients coinfected with human immunodeficiency virus (HIV) (Chesson et al., 2005). This association is especially evident in men who have sex with men (MSM). In HIV-positive patients, primary syphilis infection may progress more rapidly to the tertiary, and most destructive, stage and reinfection can start with the latent or tertiary stage; in such patients, advanced syphilis may arise without clinical warning signs (Kenyan et al., 2018). It is important to note that neurosyphilis can occur during any stage of infection in all patients, regardless of immunocompetence status (CDC, 2021). Case Presentation. A 56-year-old male with a past medical history of well-controlled HIV with a CD4 count of 700 cells/mm3 and an undetectable viral load, psoriasis, and a remote episode of treated syphilis, presented with a two-week history of a diffuse desquamating rash, alopecia, sinusitis, unilateral conjunctivitis, and blurred vision. His last sexual encounter was over ten months ago. The diagnosis of syphilis was confirmed by microhemagglutination assay, and he was treated for presumed neuro-ocular infection with a two-week course of intravenous Penicillin G. Conclusion. Syphilis has acquired a reputation as “the great masquerader” due to its protean manifestations. It may follow an unpredictable course, especially in HIV-positive patients, including those whose treatment has achieved undetectable serology. For example, ocular syphilis may present in an otherwise asymptomatic individual (Rein, 2020) and alopecia may arise as the sole indication of acute syphilitic infection (Doche et al., 2017). Therefore, a high index of suspicion is warranted in order to prevent severe and irreversible complications.

scholarly journals Lymphomatoid Papulosis in a Case of Atypical Secondary Syphilis

2019 ◽  
Vol 14 (4) ◽  
pp. e32-e33
Author(s):  
Xin (Peter) Mu ◽  
Ian Mazzetti
Keyword(s):  
Clinical History ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Low Grade ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Lymphomatoid Papulosis ◽  
History Of ◽  
Skin Biopsies ◽  
Syphilis Serology

AbstractLymphomatoid papulosis is an indolent cutaneous lymphoproliferative disorder that presents as recurrent self-resolving papulonodular skin lesions. Currently, there are no known causes for lymphomatoid papulosis and definitive diagnosis is only made histologically. A 64-year-old man presented with a 6-week history of bilateral leg pains, low-grade fevers, and a widespread eruption of painless erythematic papules. Despite testing positive for syphilis serology, he lacked the typical clinical history for classic syphilis and therefore, skin biopsies were performed to confirm the diagnosis. Unexpectedly, the skin biopsies revealed lymphomatoid papulosis which resolved with antibiotic treatments for syphilis. Considering the synchronous resolution of the patient’s syphilis infection and his cutaneous lesions, this is the first report of findings to suggest syphilis as a possible cause for lymphomatoid papulosis. Clinicians should appreciate the possibility of alternative diagnosis for cutaneous presentations in settings of confirmed syphilis infections. RESUMELa papulose lympho-matoïde est un trouble lymphoprolifératif cutané indolent qui se présente sous la forme de lésions cutanées papulonodulaires auto-résolutives récurrentes. Actuellement, il n’y a pas de causes connues de la papulose lymphomatoïde et le diagnostic définitif n’est posé que sur le plan histologique. Un homme de 64 ans a présenté une histoire de 6 semaines de douleurs bilatérales aux jambes, de fièvres de bas grade et d’éruptions généralisées de papules érythémateuses indolores. Malgré un test sérologique positif pour la syphilis, il n’avait pas les antécédents cliniques typiques de la syphilis classique et des biopsies cutanées ont donc été effectuées pour confirmer le diagnostic. De façon inattendue, les biopsies cutanées ont révélé une papulose lymphomatoïde qui s’est résorbée grâce à des traitements antibiotiques contre la syphilis. Compte tenu de la résolution synchrone de l’infection syphilitique du patient et de ses lésions cutanées, il s’agit du premier rapport de résultats suggérant que la syphilis est une cause possible de papulose lymphomatoïde. Les cliniciens devraient apprécier la possibilité d’un diagnostic alternatif pour les présentations cutanées dans les contextes d’infections syphilitiques confirmées.

scholarly journals Extensive Condylomata Lata as the Only Manifestation of Secondary Syphilis

2021 ◽  
Vol 79 (3) ◽  
pp. 279-281
Author(s):  
Rita Bouceiro-Mendes ◽  
Leandro Silva ◽  
Pablo Espinosa-Lara ◽  
Luís Soares-de-Almeida ◽  
J. Borges-da-Costa
Keyword(s):  
Young Male ◽  
Developed Countries ◽  
Secondary Syphilis ◽  
New Wave ◽  
Syphilis Infection ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Clinical Presentations ◽  
Immunodeficiency Virus ◽  
Sex With Men

Syphilis is a sexually transmitted infection with a multiplicity of clinical presentations that has been known for centuries. Recently, a new wave of syphilis has been reported in developed countries and men who have sex with men, especially those coinfected with human immunodeficiency virus (HIV), have the highest rates of syphilis infection. In these patients, cutaneous manifestation can be even more diverse. We report a case of secondary syphilis in a young male patient coinfected with HIV whose presentation consisted of extensive condylomata lata lesions.

Polymetastatic testicular cancer turns out to be secondary syphilis: a case report

Sexual Health ◽  
2020 ◽  
Vol 17 (1) ◽  
pp. 96
Author(s):  
Mateusz M. Polaczek ◽  
Katarzyna Smolarczyk ◽  
Inga Baranska ◽  
Renata Langfort ◽  
Slawomir Majewski
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Testicular Cancer ◽  
Secondary Syphilis ◽  
Life Threatening ◽  
The Right ◽  
Sexually Transmissible Infection ◽  
Transmissible Infection

Syphilis is a sexually transmissible infection, with increasing rates of infection worldwide. The differential diagnosis of syphilis should include various diseases, not excluding cancer. Making the right diagnosis can protect the patient against life-threatening complications and the repercussions of a misdiagnosis, as in the present case (orchidectomy).

scholarly journals Case Report: Culture negative cutaneous tuberculosis

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 509
Author(s):  
Maria Qadri ◽  
Qurban Hussain Sheikh ◽  
Mir Tahir Hussain Talpur ◽  
Uzair Yaqoob ◽  
Khalil Ullah Shabbir
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Wide Spectrum ◽  
Neck Region ◽  
The Body ◽  
Cervical Region ◽  
Cutaneous Lesions ◽  
Head And Neck Region ◽  
Cutaneous Tuberculosis ◽  
Culture Negative

Cutaneous tuberculosis (TB) can present in a number of ways, making it difficult to diagnose. It most commonly presents as scrofuloderma, which commonly affects the supra-clavicular region, axilla and the cervical region. All the different presentations of cutaneous TB should be known to clinicians, in order to diagnose it early. The objective of this article is to describe a case of scrofuloderma presenting with different cutaneous lesions at the same time, which were culture negative. We present a 23-year-old male with no known co-morbidities, presenting to us with fever and multiple swellings on the body. Cultures of pus and blood were negative for TB; GeneXpert detected the microorganism. Cutaneous TB, although a rare disease with wide spectrum of cutaneous lesions, should be considered in differential diagnosis of cold abscesses and nodules, especially of the head and neck region.

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